Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
NEK2	NEK2	Thr175	HDTSFAKtFVGTPYY	phosphorylation up-regulates	17197699	SIGNOR-151763
STK3	NEK2	Ser438	EKNYQLKsRQILGMR	phosphorylation up-regulates	21076410	SIGNOR-169539
NEK2	NEK2	Ser241	RRIPYRYsDELNEII	phosphorylation down-regulates	17197699	SIGNOR-151767
PP1	NEK2	–		dephosphorylation down-regulates	17283141	SIGNOR-264667
PPP1CA	NEK2	–		dephosphorylation down-regulates	17283141	SIGNOR-152949
NEK2	NEK2	Thr179	FAKTFVGtPYYMSPE	phosphorylation down-regulates	17197699	SIGNOR-151771
NEK2	NEK2	Ser171	RILNHDTsFAKTFVG	phosphorylation up-regulates	17197699	SIGNOR-151755
NEK2	NEK2	Thr170	ARILNHDtSFAKTFV	phosphorylation up-regulates	17197699	SIGNOR-151759

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
NEK2	phosphorylation up-regulates →	NEK2 PThr175	phosphorylation up-regulates →	NEK2	17197699	SIGNOR-151763
STK3	phosphorylation up-regulates →	NEK2 PSer438	phosphorylation up-regulates →	NEK2	21076410	SIGNOR-169539
NEK2	phosphorylation up-regulates →	NEK2 PSer241	phosphorylation down-regulates ⊣	NEK2	17197699	SIGNOR-151767
NEK2	phosphorylation up-regulates →	NEK2 PThr179	phosphorylation down-regulates ⊣	NEK2	17197699	SIGNOR-151771
NEK2	phosphorylation up-regulates →	NEK2 PSer171	phosphorylation up-regulates →	NEK2	17197699	SIGNOR-151755
NEK2	phosphorylation up-regulates →	NEK2 PThr170	phosphorylation up-regulates →	NEK2	17197699	SIGNOR-151759

Regulator	Mechanism/Effect	Target	SIGNOR-ID
NEK2	phosphorylation → up-regulates	NEK2	SIGNOR-151763
STK3	phosphorylation → up-regulates	NEK2	SIGNOR-169539
NEK2	phosphorylation down-regulates	NEK2	SIGNOR-151767
PP1	dephosphorylation down-regulates	NEK2	SIGNOR-264667
PPP1CA	dephosphorylation down-regulates	NEK2	SIGNOR-152949
NEK2	phosphorylation down-regulates	NEK2	SIGNOR-151771
NEK2	phosphorylation → up-regulates	NEK2	SIGNOR-151755
NEK2	phosphorylation → up-regulates	NEK2	SIGNOR-151759