| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | KIF11 | Thr926 | LDIPTGTtPQRKSYL | dephosphorylation up-regulates activity | 27492783 | SIGNOR-277000 |
| CDK1 | KIF11 | Thr926 | LDIPTGTtPQRKSYL | phosphorylation up-regulates activity | 19001501 | SIGNOR-273887 |
| CDK1 | KIF11 | Thr926 | LDIPTGTtPQRKSYL | phosphorylation up-regulates | 9235942 | SIGNOR-50169 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | dephosphorylation down-regulates ⊣ | KIF11 PThr926 | dephosphorylation down-regulates ⊣ | KIF11 | 27492783 | SIGNOR-277000 |
| CDK1 | phosphorylation up-regulates → | KIF11 PThr926 | phosphorylation up-regulates → | KIF11 | 19001501 | SIGNOR-273887 |
| CDK1 | phosphorylation up-regulates → | KIF11 PThr926 | phosphorylation up-regulates → | KIF11 | 9235942 | SIGNOR-50169 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTEN | dephosphorylation → up-regulates activity | KIF11 | SIGNOR-277000 |
| CDK1 | phosphorylation → up-regulates activity | KIF11 | SIGNOR-273887 |
| CDK1 | phosphorylation → up-regulates | KIF11 | SIGNOR-50169 |
