4.0
Summary
| Name |  KIF11View Modifications |
| Full Name | Kinesin-like protein KIF11 |
| Synonyms | Kinesin-like protein 1, Kinesin-like spindle protein HKSP, Kinesin-related motor protein Eg5, Thyroid receptor-interacting protein 5, TR-interacting protein 5, TRIP-5 | EG5, KNSL1, TRIP5 |
| Primary ID | P52732 |
| Links |  -  -  |
| Type | protein |
| Relations | 11 |
| Inhibitors | ARRY-520; N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide; 940929-33-9 |
| Function | Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NEK7 | up-regulates activity 
phosphorylation
|
KIF11 | 0.408 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | NEK6 | up-regulates activity
phosphorylation
|
KIF11 | 0.446 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK1 | up-regulates activity
phosphorylation
|
KIF11 | 0.638 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK1 | up-regulates
phosphorylation
|
KIF11 | 0.638 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTEN | up-regulates activity
dephosphorylation
|
KIF11 | 0.454 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARRY-520 | down-regulates 
chemical inhibition
|
KIF11 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KIF11 | up-regulates 
|
Spindle_assembly | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide | down-regulates
chemical inhibition
|
KIF11 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KIF11 | up-regulates
|
Plus-end directed sliding movement | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 940929-33-9 | down-regulates
chemical inhibition
|
KIF11 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TPX2 | down-regulates activity
binding
|
KIF11 | 0.501 |
| Publications: | 1 | |||