| Name | PLK1 |
| ID | P53350 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 53-305 PROSITE-ProRule
POLO box 1 410-488 PROSITE-ProRule
POLO box 2 510-592 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | CENPQ | Thr123 | RLLQQCEtLKVPPKK | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265231 |
| PLK1 | BRCA2 | Thr207 | TPPTLSStVLIVRNE | phosphorylation unknown | 12815053 | SIGNOR-249221 |
| PLK1 | TTK | Ser333 | NLKSVQNsHFKEPLV | phosphorylation up-regulates activity | 26119734 | SIGNOR-276197 |
| PLK1 | SMAD4 | Thr197 | ASTETYStPALLAPS | phosphorylation down-regulates quantity by destabilization | 35437307 | SIGNOR-277591 |
| PLK1 | SVIL | Ser238 | SFSGRDSsFTEVPRS | phosphorylation up-regulates activity | 23750008 | SIGNOR-273729 |
| PLK1 | CELSR1 | – | phosphorylation down-regulates activity | 26004507 | SIGNOR-279094 | |
| PLK1 | NEDD1 | Ser426 | VNKGSDEsIGKGDGF | phosphorylation up-regulates activity | 19509060 | SIGNOR-272992 |
| PLK1 | RBBP8 | – | phosphorylation up-regulates activity | 30202980 | SIGNOR-279253 | |
| PLK1 | TTK | Thr33 | KFKNEDLtDELSLNK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276204 |
| PLK1 | ZMYM2 | Ser303 | QKQPGVDsLSPVASL | phosphorylation down-regulates quantity by destabilization | 25855382 | SIGNOR-275559 |
| PLK1 | ARHGDIA | Thr7 | tAEQLAQI | phosphorylation up-regulates activity | 38355643 | SIGNOR-277883 |
| PLK1 | RACGAP1 | Thr260 | QPWNSDStLNSRQLE | phosphorylation up-regulates | 19468302 | SIGNOR-185758 |
| PLK1 | YY1 | Thr39 | PVETIETtVVGEEEE | phosphorylation up-regulates | 23226345 | SIGNOR-200087 |
| PLK1 | PKMYT1 | Thr495 | LLSLFEDtLDPT | phosphorylation unknown | 12738781 | SIGNOR-249208 |
| PLK1 | PINX1 | Thr317 | EDATLEEtLVKKKKK | phosphorylation down-regulates | 20573420 | SIGNOR-166333 |
| PLK1 | SUZ12 | – | phosphorylation down-regulates activity | 25855382 | SIGNOR-278423 | |
| PLK1 | ATXN10 | Ser77 | QVENLASsLQLITEC | phosphorylation down-regulates | 21857149 | SIGNOR-176122 |
| PLK1 | CENPQ | Ser139 | EDLTNVSsLLNMERA | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265233 |
| PLK1 | TTK | Ser321 | SKPSGNDsCELRNLK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276212 |
| PLK1 | TOP2A | Ser1525 | PIKYLEEsDEDDLF | phosphorylation up-regulates | 18171681 | SIGNOR-160237 |
| PLK1 | TPT1 | Ser46 | TEGNIDDsLIGGNAS | phosphorylation down-regulates | 12167714 | SIGNOR-91344 |
| PLK1 | TTK | Ser363 | LKNKTESsLLAKLEE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276208 |
| PLK1 | USP16 | Ser330 | ILKAFGNsTEKLDEE | phosphorylation up-regulates activity | 26323689 | SIGNOR-274016 |
| PLK1 | CDC25C | Ser198 | SDELMEFsLKDQEAK | phosphorylation up-regulates | 11897663 | SIGNOR-115993 |
| PLK1 | TNKS | Thr1128 | VEEEMQStIREHRDG | phosphorylation up-regulates quantity by stabilization | 21818122 | SIGNOR-276244 |
| PLK1 | EME1 | – | phosphorylation up-regulates activity | 24528857 | SIGNOR-280068 | |
| PLK1 | PTEN | – | phosphorylation down-regulates activity | 27330107 | SIGNOR-280070 | |
| PLK1 | STK3 | – | phosphorylation up-regulates activity | 29250521 | SIGNOR-280071 | |
| PLK1 | TSC1 | – | phosphorylation down-regulates quantity by destabilization | 36520312 | SIGNOR-280072 | |
| PLK1 | NINL | Ser87 | VRPSDEDsSSLESAA | phosphorylation down-regulates activity | 12852856 | SIGNOR-103352 |
| PLK1 | TNKS | Ser978 | VVSASLIsPASTPSC | phosphorylation up-regulates quantity by stabilization | 21818122 | SIGNOR-276242 |
| PLK1 | FADD | Ser194 | QNRSGAMsPMSWNSD | phosphorylation down-regulates activity | 20890306 | SIGNOR-168204 |
| PLK1 | PINX1 | Ser110 | SDKKEKKsFSLEEKS | phosphorylation down-regulates | 20573420 | SIGNOR-166317 |
| PLK1 | USP16 | Ser486 | SEYEAEMsLQGEVNI | phosphorylation up-regulates activity | 26323689 | SIGNOR-274017 |
| PLK1 | FOXM1 | Ser730 | VLDTMNDsLSKILLD | phosphorylation up-regulates | 19737929 | SIGNOR-187888 |
| PLK1 | TOP2A | Ser1337 | LDSDEDFsDFDEKTD | phosphorylation up-regulates | 18171681 | SIGNOR-160233 |
| PLK1 | GTSE1 | Ser435 | RSIRRRDsCLNSKTK | phosphorylation up-regulates | 20577264 | SIGNOR-166417 |
| PLK1 | NEDD1 | Ser397 | GKNQDFSsFDDTGKS | phosphorylation up-regulates activity | 19509060 | SIGNOR-272994 |
| PLK1 | BUB1B | Ser676 | LSPIIEDsREATHSS | phosphorylation up-regulates | 17785528 | SIGNOR-157646 |
| PLK1 | USP16 | Ser486 | SEYEAEMsLQGEVNI | phosphorylation up-regulates activity | 26323689 | SIGNOR-278270 |
| PLK1 | RIOK2 | Ser335 | TKEGSEFsFSDGEVA | phosphorylation up-regulates activity | 21880710 | SIGNOR-262937 |
| PLK1 | MDM2 | Ser260 | SLDSEDYsLSEEGQE | phosphorylation up-regulates | 19833129 | SIGNOR-188471 |
| PLK1 | PKMYT1 | Ser426 | CSLLLDSsLSSNWDD | phosphorylation unknown | 12738781 | SIGNOR-249207 |
| PLK1 | PIN1 | Ser65 | SHLLVKHsQSRRPSS | phosphorylation up-regulates | 16118204 | SIGNOR-139919 |
| PLK1 | CHEK2 | Thr68 | SSLETVStQELYSIP | phosphorylation up-regulates | 12493754 | SIGNOR-96637 |
| PLK1 | BUB1B | Thr1008 | LNANDEAtVSVLGEL | phosphorylation up-regulates | 17376779 | SIGNOR-153863 |
| PLK1 | CDCA5 | Thr151 | RSYSRLEtLGSASTS | phosphorylation down-regulates activity | 23901111 | SIGNOR-276122 |
| PLK1 | MDM2 | Ser260 | SLDSEDYsLSEEGQE | phosphorylation up-regulates | 12383858 | SIGNOR-94272 |
| PLK1 | CCNB1 | Ser128 | LVDTASPsPMETSGC | phosphorylation up-regulates activity | 11242082 | SIGNOR-105711 |
| PLK1 | TTK | Thr210 | LSASTVLtAQESFSG | phosphorylation up-regulates activity | 26119734 | SIGNOR-276219 |
| PLK1 | BRCA2 | Thr207 | TPPTLSStVLIVRNE | phosphorylation down-regulates activity | 12815053 | SIGNOR-102502 |
| PLK1 | BIRC5 | Ser20 | FLKDHRIsTFKNWPF | phosphorylation up-regulates | 21148584 | SIGNOR-170460 |
| PLK1 | TTK | Ser291 | CDVKTDDsVVPCFMK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276199 |
| PLK1 | FBXO5 | – | phosphorylation down-regulates | 15469984 | SIGNOR-129813 | |
| PLK1 | ESPL1 | Ser1399 | KVNFSDDsDLEDPVS | phosphorylation down-regulates activity | 17974570 | SIGNOR-276082 |
| PLK1 | BORA | Ser497 | SSNIQMDsGYNTQNC | phosphorylation down-regulates | 18378770 | SIGNOR-178150 |
| PLK1 | PRKN | Ser378 | AYHEGECsAVFEASG | phosphorylation up-regulates activity | 26387737 | SIGNOR-276938 |
| PLK1 | CENPU | Ser77 | TFDPPLHsTAIYADE | phosphorylation down-regulates | 17081991 | SIGNOR-150453 |
| PLK1 | BRCA2 | Ser193 | AEVDPDMsWSSSLAT | phosphorylation unknown | 12815053 | SIGNOR-249217 |
| PLK1 | BORA | Ser497 | SSNIQMDsGYNTQNC | phosphorylation down-regulates | 18521620 | SIGNOR-178803 |
| PLK1 | SNCB | Ser118 | LMEPEGEsYEDPPQE | phosphorylation down-regulates activity | 19889641 | SIGNOR-176079 |
| PLK1 | CCNB1 | Ser147 | EDLCQAFsDVILAVN | phosphorylation up-regulates activity | 11242082 | SIGNOR-105719 |
| PLK1 | TOPORS | Ser718 | KDRDGYEsSYRRRTL | phosphorylation up-regulates activity | 19473992 | SIGNOR-185838 |
| PLK1 | CLIP1 | Ser195 | LTKTASEsISNLSEA | phosphorylation up-regulates | 20664522 | SIGNOR-167172 |
| PLK1 | WEE1 | Ser123 | EEGFGSSsPVKSPAA | phosphorylation down-regulates | 16085715 | SIGNOR-139473 |
| PLK1 | KIF2A | Thr554 | ANRVKELtVDPTAAG | phosphorylation up-regulates activity | 25660017 | SIGNOR-278380 |
| PLK1 | KIF2B | Ser204 | HLDSSKIsVLEPPQE | phosphorylation up-regulates activity | 22535524 | SIGNOR-252050 |
| PLK1 | PRKDC | Ser3205 | TPLPEDNsMNVDQDG | phosphorylation up-regulates activity | 24844881 | SIGNOR-278188 |
| PLK1 | CDH1 | Ser146 | LLTFPNSsPGLRRQK | phosphorylation down-regulates quantity by destabilization | 23972993 | SIGNOR-274054 |
| PLK1 | BRCA2 | Ser193 | AEVDPDMsWSSSLAT | phosphorylation down-regulates activity | 12815053 | SIGNOR-102486 |
| PLK1 | DCTN1 | Ser179 | SASAGELsSSEPSTP | phosphorylation up-regulates | 20679239 | SIGNOR-167281 |
| PLK1 | HSF1 | Ser216 | IPLMLNDsGSAHSMP | phosphorylation down-regulates | 18794143 | SIGNOR-180915 |
| PLK1 | TEX14 | Ser437 | QKAATVKsDIYSFSM | phosphorylation down-regulates quantity by destabilization | 22405274 | SIGNOR-273529 |
| PLK1 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates activity | 27003818 | SIGNOR-278190 |
| PLK1 | BRCA2 | Ser206 | ATPPTLSsTVLIVRN | phosphorylation unknown | 12815053 | SIGNOR-249219 |
| PLK1 | CENPQ | Ser138 | MEDLTNVsSLLNMER | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265228 |
| PLK1 | BORA | Thr501 | QMDSGYNtQNCGSNI | phosphorylation down-regulates | 18521620 | SIGNOR-178807 |
| PLK1 | MYC | – | phosphorylation up-regulates activity | 23887393 | SIGNOR-243522 | |
| PLK1 | BUB1 | – | phosphorylation up-regulates activity | 25540073 | SIGNOR-279251 | |
| PLK1 | YBX1 | Ser176 | EKNEGSEsAPEGQAQ | phosphorylation up-regulates quantity | 36805592 | SIGNOR-279255 |
| PLK1 | RPTOR | – | phosphorylation up-regulates activity | 28102733 | SIGNOR-279346 | |
| PLK1 | REST | Ser1030 | MSEGSDDsGLHGARP | phosphorylation down-regulates activity | 25453754 | SIGNOR-279380 |
| PLK1 | SREBF1 | Ser486 | SRGMLDRsRLALCTL | phosphorylation up-regulates activity | 27579997 | SIGNOR-279383 |
| PLK1 | BEX4 | Thr107 | RHYMRFQtPEPDNHY | phosphorylation up-regulates activity | 30367032 | SIGNOR-279550 |
| PLK1 | GORASP1 | – | phosphorylation down-regulates quantity | 20214750 | SIGNOR-279554 | |
| PLK1 | STK38 | Thr407 | EIKSIDDtSNFDEFP | phosphorylation down-regulates activity | 26057687 | SIGNOR-276915 |
| PLK1 | KIF4A | – | phosphorylation down-regulates activity | 28817632 | SIGNOR-280069 | |
| PLK1 | KIF2C | – | phosphorylation up-regulates activity | 21078677 | SIGNOR-278908 | |
| PLK1 | TP73 | Thr27 | SSLEPDStYFDLPQS | phosphorylation down-regulates | 18418051 | SIGNOR-178253 |
| PLK1 | PARP10 | Thr601 | EVRELLAtLEGLDLD | phosphorylation up-regulates activity | 32060423 | SIGNOR-273728 |
| PLK1 | TTK | Thr594 | RLYDYEItDQYIYMV | phosphorylation up-regulates activity | 26119734 | SIGNOR-276221 |
| PLK1 | FOXO3 | – | phosphorylation down-regulates activity | 26280018 | SIGNOR-279095 | |
| PLK1 | KIF2C | Ser715 | MQLEEQAsRQISSKK | phosphorylation up-regulates activity | 26206521 | SIGNOR-276931 |
| PLK1 | TERF1 | Ser435 | KKLKLISsDSED | phosphorylation up-regulates | 18625707 | SIGNOR-179461 |
| PLK1 | CCNT1 | Ser564 | KTYSLSSsFSSSSST | phosphorylation down-regulates activity | 23977272 | SIGNOR-276501 |
| PLK1 | TNKS | Thr930 | LAHGADPtMKNQEGQ | phosphorylation up-regulates quantity by stabilization | 21818122 | SIGNOR-276243 |
| PLK1 | PINX1 | Ser226 | ATGKDVEsYLQPKAK | phosphorylation down-regulates | 20573420 | SIGNOR-166325 |
| PLK1 | USP16 | Ser386 | HESFLDLsLPVLDDQ | phosphorylation up-regulates activity | 26323689 | SIGNOR-274015 |
| PLK1 | CLSPN | Ser30 | EADSPSDsGQGSYET | phosphorylation down-regulates | 16885022 | SIGNOR-148447 |
| PLK1 | PKMYT1 | Thr495 | LLSLFEDtLDPT | phosphorylation down-regulates activity | 12738781 | SIGNOR-263097 |
| PLK1 | TNKS | Thr982 | SLISPAStPSCLSAA | phosphorylation up-regulates quantity by stabilization | 21818122 | SIGNOR-276241 |
| PLK1 | CDC20 | Ser170 | KTCRYIPsLPDRILD | phosphorylation down-regulates quantity by destabilization | 23643811 | SIGNOR-276493 |
| PLK1 | PTPN1 | Ser286 | KFIMGDSsVQDQWKE | phosphorylation up-regulates activity | 23348582 | SIGNOR-272990 |
| PLK1 | CLSPN | Ser30 | EADSPSDsGQGSYET | phosphorylation down-regulates | 16885021 | SIGNOR-148442 |
| PLK1 | RIOK2 | Ser380 | PEQIKEDsLSEESAD | phosphorylation up-regulates activity | 21880710 | SIGNOR-262938 |
| PLK1 | TRIOBP | Thr2229 | QAEEREHtLRRCQQE | phosphorylation up-regulates | 22820163 | SIGNOR-198353 |
| PLK1 | G6PD | Thr466 | REAWRIFtPLLHQIE | phosphorylation up-regulates activity | 29138396 | SIGNOR-267581 |
| PLK1 | KAT7 | Ser57 | SQSSQDSsPVRNLQS | phosphorylation up-regulates | 18250300 | SIGNOR-160751 |
| PLK1 | STARD9 | Ser312 | SVSNGGDsGILSSPS | phosphorylation down-regulates quantity by destabilization | 25501367 | SIGNOR-279804 |
| PLK1 | TTK | Ser362 | TLKNKTEsSLLAKLE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276200 |
| PLK1 | CENPQ | Thr135 | PKKMEDLtNVSSLLN | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265234 |
| PLK1 | DVL2 | Thr206 | MTSELEStSLGDSDE | phosphorylation up-regulates | 20823832 | SIGNOR-167858 |
| PLK1 | ATXN10 | Thr82 | ASSLQLItECFRCLR | phosphorylation down-regulates | 21857149 | SIGNOR-176126 |
| PLK1 | ECT2 | – | phosphorylation up-regulates activity | 17488623 | SIGNOR-279553 | |
| PLK1 | CENPQ | Ser249 | LDILHNSsQMKSMST | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265230 |
| PLK1 | NOTCH1 | – | phosphorylation down-regulates activity | 31597699 | SIGNOR-279096 | |
| PLK1 | SUGT1 | Ser331 | VKRAMNKsFMESGGT | phosphorylation up-regulates activity | 22869522 | SIGNOR-265222 |
| PLK1 | WEE1 | Ser53 | GHSTGEDsAFQEPDS | phosphorylation down-regulates | 15350223 | SIGNOR-128643 |
| PLK1 | CNTROB | – | phosphorylation up-regulates activity | 23291182 | SIGNOR-279551 | |
| PLK1 | YBX1 | Ser174 | SGEKNEGsESAPEGQ | phosphorylation up-regulates quantity | 36805592 | SIGNOR-279254 |
| PLK1 | CCNB1 | Ser126 | PILVDTAsPSPMETS | phosphorylation up-regulates activity | 11242082 | SIGNOR-105707 |
| PLK1 | NCAPH2 | Ser288 | ESRSPQQsAALPRRY | phosphorylation up-regulates activity | 28717250 | SIGNOR-278419 |
| PLK1 | SREBF1 | Ser467 | DSPVFEDsKAKPEQR | phosphorylation up-regulates activity | 27579997 | SIGNOR-279382 |
| PLK1 | ZMYM2 | Ser309 | DSLSPVAsLPKQIFQ | phosphorylation down-regulates quantity by destabilization | 25855382 | SIGNOR-275560 |
| PLK1 | AXIN2 | Ser311 | SDALTDDsMSMTDSS | phosphorylation up-regulates activity | 26438599 | SIGNOR-277180 |
| PLK1 | SUN1 | Ser138 | RPPVLDEsWIREQTT | phosphorylation down-regulates activity | 25482198 | SIGNOR-263098 |
| PLK1 | BRCA2 | Ser206 | ATPPTLSsTVLIVRN | phosphorylation down-regulates activity | 12815053 | SIGNOR-102494 |
| PLK1 | G6PD | Thr406 | AVYTKMMtKKPGMFF | phosphorylation up-regulates activity | 29138396 | SIGNOR-267580 |
| PLK1 | CENPU | Thr78 | FDPPLHStAIYADEE | phosphorylation down-regulates | 17081991 | SIGNOR-150457 |
| PLK1 | RAF1 | Ser339 | PRGQRDSsYYWEIEA | phosphorylation up-regulates activity | 27003818 | SIGNOR-278191 |
| PLK1 | MAD2L1BP | Ser102 | KHFYRKPsPQAEEML | phosphorylation down-regulates activity | 31118282 | SIGNOR-265970 |
| PLK1 | NUMA1 | – | phosphorylation down-regulates activity | 30456393 | SIGNOR-279345 | |
| PLK1 | SPAG5 | – | phosphorylation up-regulates activity | 33288550 | SIGNOR-279423 | |
| PLK1 | BUB1B | Thr792 | PRNSAELtVIKVSSQ | phosphorylation up-regulates | 17376779 | SIGNOR-153867 |
| PLK1 | CLIP1 | Ser312 | ASLKRSPsASSLSSM | phosphorylation down-regulates activity | 24451569 | SIGNOR-264575 |
| PLK1 | TOP2A | Ser1525 | PIKYLEEsDEDDLF | phosphorylation up-regulates | 19098900 | SIGNOR-182844 |
| PLK1 | RANBP1 | – | phosphorylation up-regulates activity | 21813642 | SIGNOR-279751 | |
| PLK1 | BORA | Thr501 | QMDSGYNtQNCGSNI | phosphorylation down-regulates | 18378770 | SIGNOR-178154 |
| PLK1 | ZMYM2 | – | phosphorylation down-regulates | 25855382 | SIGNOR-278491 | |
| PLK1 | ARHGDIA | Thr91 | GPLELDLtGDLESFK | phosphorylation up-regulates activity | 38355643 | SIGNOR-277882 |
| PLK1 | RACGAP1 | Ser214 | AVDQGNEsIVAKTTV | phosphorylation up-regulates | 19468302 | SIGNOR-185754 |
| PLK1 | RIOK2 | Ser548 | KSSLEAAsFWGE | phosphorylation up-regulates activity | 21880710 | SIGNOR-262939 |
| PLK1 | KIF2C | Ser621 | ALIPGNLsKEEEELS | phosphorylation down-regulates quantity by destabilization | 25504441 | SIGNOR-276862 |
| PLK1 | TTK | Ser345 | PLVSDEKsSELIITD | phosphorylation up-regulates activity | 26119734 | SIGNOR-276198 |
| PLK1 | BRCA2 | Thr203 | SSLATPPtLSSTVLI | phosphorylation unknown | 12815053 | SIGNOR-249220 |
| PLK1 | TNKS | Thr839 | DTQGRNStPLHLAAG | phosphorylation up-regulates quantity by stabilization | 21818122 | SIGNOR-276245 |
| PLK1 | CENPQ | Thr256 | SQMKSMStFIEEAYK | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265229 |
| PLK1 | KIF2B | Thr125 | MIPQKNQtASGDSLD | phosphorylation up-regulates activity | 22535524 | SIGNOR-252049 |
| PLK1 | PKMYT1 | Ser426 | CSLLLDSsLSSNWDD | phosphorylation down-regulates activity | 12738781 | SIGNOR-263096 |
| PLK1 | IKBKB | Ser733 | TVREQDQsFTALDWS | phosphorylation down-regulates | 18957422 | SIGNOR-181798 |
| PLK1 | ESPL1 | Thr1363 | AGPHVPFtVFEEVCP | phosphorylation down-regulates activity | 17974570 | SIGNOR-276083 |
| PLK1 | CEP192 | Thr44 | GLPVAVStLARDRSS | phosphorylation up-regulates activity | 26012549 | SIGNOR-266405 |
| PLK1 | CASP8 | Ser305 | IYQLMDHsNMDCFIC | phosphorylation down-regulates quantity by destabilization | 24484936 | SIGNOR-272989 |
| PLK1 | BRCA2 | Ser205 | LATPPTLsSTVLIVR | phosphorylation unknown | 12815053 | SIGNOR-249218 |
| PLK1 | RAN | Ser135 | DRKVKAKsIVFHRKK | phosphorylation up-regulates | 16930555 | SIGNOR-149073 |
| PLK1 | RAP1GAP | Ser525 | AGQKTPDsGHVSQEP | phosphorylation down-regulates | 25329897 | SIGNOR-205577 |
| PLK1 | CDC25B | – | phosphorylation up-regulates activity | 21640712 | SIGNOR-267560 | |
| PLK1 | NPM1 | Ser4 | sMDMDMSP | phosphorylation up-regulates | 15190079 | SIGNOR-125666 |
| PLK1 | KIF20A | – | phosphorylation up-regulates activity | 12939256 | SIGNOR-278201 | |
| PLK1 | PRC1 | – | phosphorylation down-regulates activity | 22621898 | SIGNOR-279645 | |
| PLK1 | TEX14 | – | phosphorylation down-regulates quantity by destabilization | 22405274 | SIGNOR-279646 | |
| PLK1 | TTK | Thr458 | CKTPSSNtLDDYMSC | phosphorylation up-regulates activity | 26119734 | SIGNOR-276222 |
| PLK1 | TTK | Ser37 | EDLTDELsLNKISAD | phosphorylation up-regulates activity | 26119734 | SIGNOR-276206 |
| PLK1 | NUP35 | – | phosphorylation down-regulates activity | 29065306 | SIGNOR-279252 | |
| PLK1 | CENPQ | Ser255 | SSQMKSMsTFIEEAY | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265226 |
| PLK1 | TRIOBP | Thr447 | ASSPSRAtRDNPTTS | phosphorylation up-regulates | 22820163 | SIGNOR-198357 |
| PLK1 | VIM | Ser83 | GVRLLQDsVDFSLAD | phosphorylation up-regulates | 18056432 | SIGNOR-159386 |
| PLK1 | CCNB1 | Ser133 | SPSPMETsGCAPAEE | phosphorylation up-regulates activity | 11242082 | SIGNOR-105715 |
| PLK1 | KIF2C | Ser632 | EELSSQMsSFNEAMT | phosphorylation up-regulates activity | 25504441 | SIGNOR-276863 |
| PLK1 | TPT1 | Ser64 | PEGEGTEsTVITGVD | phosphorylation down-regulates | 12167714 | SIGNOR-91348 |
| PLK1 | CLASP2 | Ser1234 | QGYDNSEsSVRKACV | phosphorylation up-regulates activity | 23045552 | SIGNOR-278321 |
| PLK1 | NINL | Ser88 | RPSDEDSsSLESAAS | phosphorylation down-regulates activity | 12852856 | SIGNOR-103356 |
| PLK1 | SUZ12 | Ser546 | SMSEFLEsEDGEVEQ | phosphorylation down-regulates quantity by destabilization | 25855382 | SIGNOR-275556 |
| PLK1 | TTK | Thr564 | LEEADNQtLDSYRNE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276214 |
| PLK1 | CEP85 | – | phosphorylation up-regulates activity | 30611117 | SIGNOR-278367 | |
| PLK1 | FOXM1 | Ser739 | SKILLDIsFPGLDED | phosphorylation up-regulates | 19737929 | SIGNOR-187892 |
| PLK1 | SREBF1 | Thr424 | VKTEVEDtLTPPPSD | phosphorylation up-regulates activity | 27579997 | SIGNOR-279381 |
| PLK1 | ZMYM2 | Ser305 | QPGVDSLsPVASLPK | phosphorylation down-regulates quantity by destabilization | 25855382 | SIGNOR-275558 |
| PLK1 | TTK | – | phosphorylation up-regulates activity | 26119734 | SIGNOR-278246 | |
| PLK1 | BRCA2 | Ser205 | LATPPTLsSTVLIVR | phosphorylation down-regulates activity | 12815053 | SIGNOR-102490 |
| PLK1 | NEDD1 | Thr382 | PRSINTDtLSKETDS | phosphorylation up-regulates activity | 19509060 | SIGNOR-272993 |
| PLK1 | STK38 | Thr7 | tPCSSMSN | phosphorylation down-regulates activity | 26057687 | SIGNOR-278420 |
| PLK1 | STK38 | Thr407 | EIKSIDDtSNFDEFP | phosphorylation down-regulates activity | 26057687 | SIGNOR-278421 |
| PLK1 | STK38 | Thr183 | TLLMKKDtLTEEETQ | phosphorylation down-regulates activity | 26057687 | SIGNOR-278422 |
| PLK1 | STK38 | Thr183 | TLLMKKDtLTEEETQ | phosphorylation down-regulates activity | 26057687 | SIGNOR-276913 |
| PLK1 | CDH1 | – | phosphorylation down-regulates quantity by destabilization | 23972993 | SIGNOR-274053 | |
| PLK1 | LRRK1 | Ser1817 | GDSIADVsIMYSEEL | phosphorylation up-regulates activity | 26192437 | SIGNOR-275467 |
| PLK1 | TTK | Thr12 | DLSGRELtIDSIMNK | phosphorylation up-regulates activity | 26119734 | SIGNOR-276202 |
| PLK1 | KIZ | Thr379 | WSTSSDLtISISEDD | phosphorylation up-regulates | 16980960 | SIGNOR-149630 |
| PLK1 | STK38 | Thr7 | tPCSSMSN | phosphorylation down-regulates activity | 26057687 | SIGNOR-276914 |
| PLK1 | NINL | Thr161 | SDEEAEStKEAQNEL | phosphorylation down-regulates activity | 12852856 | SIGNOR-103364 |
| PLK1 | TTK | Ser108 | DKYGQNEsFARIQVR | phosphorylation up-regulates activity | 26119734 | SIGNOR-276220 |
| PLK1 | PINX1 | Thr141 | DLSSRSKtDLDCIFG | phosphorylation down-regulates | 20573420 | SIGNOR-166329 |
| PLK1 | WEE1 | Ser53 | GHSTGEDsAFQEPDS | phosphorylation down-regulates quantity by destabilization | 16085715 | SIGNOR-276040 |
| PLK1 | NEDD1 | Ser637 | HSLLERYsVNEGLVA | phosphorylation up-regulates activity | 19509060 | SIGNOR-272991 |
| PLK1 | TTK | Thr46 | NKISADTtDNSGTVN | phosphorylation up-regulates activity | 26119734 | SIGNOR-276218 |
| PLK1 | TP53BP1 | Ser1618 | LTKAADIsLDNLVEG | phosphorylation down-regulates activity | 24703952 | SIGNOR-264413 |
| PLK1 | WDCP | Ser695 | SHSPGAVsSLKVFTG | phosphorylation up-regulates activity | 30297404 | SIGNOR-273731 |
| PLK1 | HASPIN | – | phosphorylation up-regulates activity | 24413556 | SIGNOR-275421 | |
| PLK1 | BRCA2 | Thr203 | SSLATPPtLSSTVLI | phosphorylation down-regulates activity | 12815053 | SIGNOR-102498 |
| PLK1 | IKBKB | Ser740 | SFTALDWsWLQTEEE | phosphorylation down-regulates | 18957422 | SIGNOR-181802 |
| PLK1 | TNKS | – | phosphorylation up-regulates quantity by stabilization | 21818122 | SIGNOR-279752 | |
| PLK1 | IRS1 | Ser24 | GYLRKPKsMHKRFFV | phosphorylation down-regulates activity | 15849359 | SIGNOR-135688 |
| PLK1 | MAD1L1 | Thr680 | SKMQLLEtEFSHTVG | phosphorylation up-regulates activity | 18922800 | SIGNOR-276173 |
| PLK1 | NOTCH1 | Ser1791 | REPLGEDsVGLKPLK | phosphorylation down-regulates quantity by destabilization | 31597699 | SIGNOR-277491 |
| PLK1 | KIF2C | Ser633 | ELSSQMSsFNEAMTQ | phosphorylation up-regulates activity | 25504441 | SIGNOR-276861 |
| PLK1 | RACGAP1 | Ser170 | ESLDWDSsLVKTFKL | phosphorylation up-regulates | 19468302 | SIGNOR-185750 |
| PLK1 | TTK | Ser214 | TVLTAQEsFSGSLGH | phosphorylation up-regulates activity | 26119734 | SIGNOR-276216 |
| PLK1 | KLF4 | Ser234 | GKFVLKAsLSAPGSE | phosphorylation up-regulates quantity by stabilization | 31281496 | SIGNOR-277463 |
| PLK1 | STARD9 | Ser312 | SVSNGGDsGILSSPS | phosphorylation down-regulates quantity by destabilization | 25501367 | SIGNOR-279806 |
| PLK1 | PINX1 | Ser117 | SFSLEEKsKISKNRV | phosphorylation down-regulates | 20573420 | SIGNOR-166321 |
| PLK1 | RSF1 | Ser1359 | ENVGKVGsPLDYSLV | phosphorylation up-regulates activity | 26259146 | SIGNOR-273590 |
| PLK1 | SUZ12 | Ser539 | RPKRTKAsMSEFLES | phosphorylation down-regulates quantity by destabilization | 25855382 | SIGNOR-275557 |
| PLK1 | SUZ12 | Ser541 | KRTKASMsEFLESED | phosphorylation down-regulates quantity by destabilization | 25855382 | SIGNOR-275555 |
| PLK1 | OPTN | Ser177 | SSGSSEDsFVEIRMA | phosphorylation up-regulates | 22365832 | SIGNOR-196367 |
| PLK1 | BUB1B | Thr680 | IEDSREAtHSSGFSG | phosphorylation up-regulates | 23079597 | SIGNOR-199222 |
| PLK1 | NUDC | Ser326 | QHPEMDFsKAKFN | phosphorylation up-regulates activity | 12852857 | SIGNOR-103407 |
| PLK1 | WDCP | Ser686 | RSDVFRDsFSHSPGA | phosphorylation up-regulates activity | 30297404 | SIGNOR-273730 |
| PLK1 | NOTCH1 | Ser2439 | SFLSGEPsQADVQPL | phosphorylation down-regulates quantity by destabilization | 31597699 | SIGNOR-277490 |
| PLK1 | AHR | Ser489 | ENNFFNEsMNECRNW | phosphorylation down-regulates activity | 37988371 | SIGNOR-277885 |
| PLK1 | CTNNB1 | Ser718 | QDDPSYRsFHSGGYG | phosphorylation unknown | 19001871 | SIGNOR-182150 |
| PLK1 | RACGAP1 | Ser157 | GSILSDIsFDKTDES | phosphorylation up-regulates | 19468302 | SIGNOR-185746 |
| PLK1 | CEP55 | Ser436 | PTAALNEsLVECPKC | phosphorylation up-regulates | 16198290 | SIGNOR-140898 |
| PLK1 | DNMT3A | Ser393 | VCHDSDEsDTAKAVE | phosphorylation down-regulates activity | 34051063 | SIGNOR-279552 |
| PLK1 | FBXO5 | – | phosphorylation down-regulates | 16439210 | SIGNOR-142949 | |
| PLK1 | CENPQ | Ser248 | DLDILHNsSQMKSMS | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265227 |
| PLK1 | WEE1 | Ser53 | GHSTGEDsAFQEPDS | phosphorylation down-regulates | 16085715 | SIGNOR-139477 |
| PLK1 | CHEK2 | Thr26 | SQPHGSVtQSQGSSS | phosphorylation unknown | 12493754 | SIGNOR-249180 |
| PLK1 | MRE11 | Ser649 | EVIEVDEsDVEEDIF | phosphorylation down-regulates activity | 28512243 | SIGNOR-265943 |
| PLK1 | IKBKB | Ser750 | QTEEEEHsCLEQAS | phosphorylation down-regulates | 18957422 | SIGNOR-181806 |
| PLK1 | RAD51 | Ser14 | LEANADTsVEEESFG | phosphorylation up-regulates activity | 26811421 | SIGNOR-278187 |
| PLK1 | NEK9 | Thr210 | SEYSMAEtLVGTPYY | phosphorylation up-regulates activity | 21642957 | SIGNOR-273888 |
| PLK1 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 19889641 | SIGNOR-189045 |
| PLK1 | FOXO1 | – | phosphorylation down-regulates activity | 32704044 | SIGNOR-278269 | |
| PLK1 | CDC6 | Thr37 | SDAKLEPtNVQTVTC | phosphorylation up-regulates | 21041660 | SIGNOR-169184 |
| PLK1 | WEE1 | Ser53 | GHSTGEDsAFQEPDS | phosphorylation down-regulates | 15070733 | SIGNOR-123832 |
| PLK1 | CEP68 | Ser332 | ADPVLQDsGVDLDSF | phosphorylation down-regulates quantity by destabilization | 25503564 | SIGNOR-275621 |
| PLK1 | PLEKHG6 | Thr574 | HLVVTEDtDEDAPLV | phosphorylation up-regulates | 18694934 | SIGNOR-179954 |
| PLK1 | NUDC | Ser274 | KKINPENsKLSDLDS | phosphorylation up-regulates activity | 12852857 | SIGNOR-103403 |
| PLK1 | STK3 | Ser15 | KSKLKKLsEDSLTKQ | phosphorylation down-regulates activity | 37739411 | SIGNOR-277904 |
| PLK1 | MAP9 | Ser289 | SDENKENsFSADHVT | phosphorylation up-regulates | 20615875 | SIGNOR-166564 |
| PLK1 | TTK | Thr371 | LLAKLEEtKEYQEPE | phosphorylation up-regulates activity | 26119734 | SIGNOR-276210 |
| PLK1 | CENPQ | Ser253 | HNSSQMKsMSTFIEE | phosphorylation down-regulates quantity by destabilization | 25670858 | SIGNOR-265232 |
| PLK1 | NINL | Ser686 | LEELHEKsQEVIWGL | phosphorylation down-regulates activity | 12852856 | SIGNOR-103348 |
| PLK1 | ANAPC1 | Ser355 | AALSRAHsPALGVHS | phosphorylation up-regulates | 14657031 | SIGNOR-119881 |
| PLK1 | SRI | Thr155 | YSTNGKItFDDYIAC | phosphorylation unknown | 24427308 | SIGNOR-203732 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | CENPQ PThr123 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265231 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PThr207 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-249221 |
| PLK1 | phosphorylation up-regulates → | TTK PSer333 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276197 |
| PLK1 | phosphorylation up-regulates → | SMAD4 PThr197 | phosphorylation down-regulates ⊣ | SMAD4 | 35437307 | SIGNOR-277591 |
| PLK1 | phosphorylation up-regulates → | SVIL PSer238 | phosphorylation up-regulates → | SVIL | 23750008 | SIGNOR-273729 |
| PLK1 | phosphorylation up-regulates → | NEDD1 PSer426 | phosphorylation up-regulates → | NEDD1 | 19509060 | SIGNOR-272992 |
| PLK1 | phosphorylation up-regulates → | TTK PThr33 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276204 |
| PLK1 | phosphorylation up-regulates → | ZMYM2 PSer303 | phosphorylation down-regulates ⊣ | ZMYM2 | 25855382 | SIGNOR-275559 |
| PLK1 | phosphorylation up-regulates → | ARHGDIA PThr7 | phosphorylation up-regulates → | ARHGDIA | 38355643 | SIGNOR-277883 |
| PLK1 | phosphorylation up-regulates → | RACGAP1 PThr260 | phosphorylation up-regulates → | RACGAP1 | 19468302 | SIGNOR-185758 |
| PLK1 | phosphorylation up-regulates → | YY1 PThr39 | phosphorylation up-regulates → | YY1 | 23226345 | SIGNOR-200087 |
| PLK1 | phosphorylation up-regulates → | PKMYT1 PThr495 | phosphorylation down-regulates ⊣ | PKMYT1 | 12738781 | SIGNOR-249208 |
| PLK1 | phosphorylation up-regulates → | PINX1 PThr317 | phosphorylation down-regulates ⊣ | PINX1 | 20573420 | SIGNOR-166333 |
| PLK1 | phosphorylation up-regulates → | ATXN10 PSer77 | phosphorylation down-regulates ⊣ | ATXN10 | 21857149 | SIGNOR-176122 |
| PLK1 | phosphorylation up-regulates → | CENPQ PSer139 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265233 |
| PLK1 | phosphorylation up-regulates → | TTK PSer321 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276212 |
| PLK1 | phosphorylation up-regulates → | TOP2A PSer1525 | phosphorylation up-regulates → | TOP2A | 18171681 | SIGNOR-160237 |
| PLK1 | phosphorylation up-regulates → | TPT1 PSer46 | phosphorylation down-regulates ⊣ | TPT1 | 12167714 | SIGNOR-91344 |
| PLK1 | phosphorylation up-regulates → | TTK PSer363 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276208 |
| PLK1 | phosphorylation up-regulates → | USP16 PSer330 | phosphorylation up-regulates → | USP16 | 26323689 | SIGNOR-274016 |
| PLK1 | phosphorylation up-regulates → | CDC25C PSer198 | phosphorylation up-regulates → | CDC25C | 11897663 | SIGNOR-115993 |
| PLK1 | phosphorylation up-regulates → | TNKS PThr1128 | phosphorylation up-regulates → | TNKS | 21818122 | SIGNOR-276244 |
| PLK1 | phosphorylation up-regulates → | NINL PSer87 | phosphorylation down-regulates ⊣ | NINL | 12852856 | SIGNOR-103352 |
| PLK1 | phosphorylation up-regulates → | TNKS PSer978 | phosphorylation up-regulates → | TNKS | 21818122 | SIGNOR-276242 |
| PLK1 | phosphorylation up-regulates → | FADD PSer194 | phosphorylation down-regulates ⊣ | FADD | 20890306 | SIGNOR-168204 |
| PLK1 | phosphorylation up-regulates → | PINX1 PSer110 | phosphorylation down-regulates ⊣ | PINX1 | 20573420 | SIGNOR-166317 |
| PLK1 | phosphorylation up-regulates → | USP16 PSer486 | phosphorylation up-regulates → | USP16 | 26323689 | SIGNOR-274017 |
| PLK1 | phosphorylation up-regulates → | FOXM1 PSer730 | phosphorylation up-regulates → | FOXM1 | 19737929 | SIGNOR-187888 |
| PLK1 | phosphorylation up-regulates → | TOP2A PSer1337 | phosphorylation up-regulates → | TOP2A | 18171681 | SIGNOR-160233 |
| PLK1 | phosphorylation up-regulates → | GTSE1 PSer435 | phosphorylation up-regulates → | GTSE1 | 20577264 | SIGNOR-166417 |
| PLK1 | phosphorylation up-regulates → | NEDD1 PSer397 | phosphorylation up-regulates → | NEDD1 | 19509060 | SIGNOR-272994 |
| PLK1 | phosphorylation up-regulates → | BUB1B PSer676 | phosphorylation up-regulates → | BUB1B | 17785528 | SIGNOR-157646 |
| PLK1 | phosphorylation up-regulates → | USP16 PSer486 | phosphorylation up-regulates → | USP16 | 26323689 | SIGNOR-278270 |
| PLK1 | phosphorylation up-regulates → | RIOK2 PSer335 | phosphorylation up-regulates → | RIOK2 | 21880710 | SIGNOR-262937 |
| PLK1 | phosphorylation up-regulates → | MDM2 PSer260 | phosphorylation up-regulates → | MDM2 | 19833129 | SIGNOR-188471 |
| PLK1 | phosphorylation up-regulates → | PKMYT1 PSer426 | phosphorylation down-regulates ⊣ | PKMYT1 | 12738781 | SIGNOR-249207 |
| PLK1 | phosphorylation up-regulates → | PIN1 PSer65 | phosphorylation up-regulates → | PIN1 | 16118204 | SIGNOR-139919 |
| PLK1 | phosphorylation up-regulates → | CHEK2 PThr68 | phosphorylation up-regulates → | CHEK2 | 12493754 | SIGNOR-96637 |
| PLK1 | phosphorylation up-regulates → | BUB1B PThr1008 | phosphorylation up-regulates → | BUB1B | 17376779 | SIGNOR-153863 |
| PLK1 | phosphorylation up-regulates → | CDCA5 PThr151 | phosphorylation down-regulates ⊣ | CDCA5 | 23901111 | SIGNOR-276122 |
| PLK1 | phosphorylation up-regulates → | MDM2 PSer260 | phosphorylation up-regulates → | MDM2 | 12383858 | SIGNOR-94272 |
| PLK1 | phosphorylation up-regulates → | CCNB1 PSer128 | phosphorylation up-regulates → | CCNB1 | 11242082 | SIGNOR-105711 |
| PLK1 | phosphorylation up-regulates → | TTK PThr210 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276219 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PThr207 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-102502 |
| PLK1 | phosphorylation up-regulates → | BIRC5 PSer20 | phosphorylation up-regulates → | BIRC5 | 21148584 | SIGNOR-170460 |
| PLK1 | phosphorylation up-regulates → | TTK PSer291 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276199 |
| PLK1 | phosphorylation up-regulates → | ESPL1 PSer1399 | phosphorylation down-regulates ⊣ | ESPL1 | 17974570 | SIGNOR-276082 |
| PLK1 | phosphorylation up-regulates → | BORA PSer497 | phosphorylation down-regulates ⊣ | BORA | 18378770 | SIGNOR-178150 |
| PLK1 | phosphorylation up-regulates → | PRKN PSer378 | phosphorylation up-regulates → | PRKN | 26387737 | SIGNOR-276938 |
| PLK1 | phosphorylation up-regulates → | CENPU PSer77 | phosphorylation down-regulates ⊣ | CENPU | 17081991 | SIGNOR-150453 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer193 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-249217 |
| PLK1 | phosphorylation up-regulates → | BORA PSer497 | phosphorylation down-regulates ⊣ | BORA | 18521620 | SIGNOR-178803 |
| PLK1 | phosphorylation up-regulates → | SNCB PSer118 | phosphorylation down-regulates ⊣ | SNCB | 19889641 | SIGNOR-176079 |
| PLK1 | phosphorylation up-regulates → | CCNB1 PSer147 | phosphorylation up-regulates → | CCNB1 | 11242082 | SIGNOR-105719 |
| PLK1 | phosphorylation up-regulates → | TOPORS PSer718 | phosphorylation up-regulates → | TOPORS | 19473992 | SIGNOR-185838 |
| PLK1 | phosphorylation up-regulates → | CLIP1 PSer195 | phosphorylation up-regulates → | CLIP1 | 20664522 | SIGNOR-167172 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer123 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-139473 |
| PLK1 | phosphorylation up-regulates → | KIF2A PThr554 | phosphorylation up-regulates → | KIF2A | 25660017 | SIGNOR-278380 |
| PLK1 | phosphorylation up-regulates → | KIF2B PSer204 | phosphorylation up-regulates → | KIF2B | 22535524 | SIGNOR-252050 |
| PLK1 | phosphorylation up-regulates → | PRKDC PSer3205 | phosphorylation up-regulates → | PRKDC | 24844881 | SIGNOR-278188 |
| PLK1 | phosphorylation up-regulates → | CDH1 PSer146 | phosphorylation down-regulates ⊣ | CDH1 | 23972993 | SIGNOR-274054 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer193 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-102486 |
| PLK1 | phosphorylation up-regulates → | DCTN1 PSer179 | phosphorylation up-regulates → | DCTN1 | 20679239 | SIGNOR-167281 |
| PLK1 | phosphorylation up-regulates → | HSF1 PSer216 | phosphorylation down-regulates ⊣ | HSF1 | 18794143 | SIGNOR-180915 |
| PLK1 | phosphorylation up-regulates → | TEX14 PSer437 | phosphorylation down-regulates ⊣ | TEX14 | 22405274 | SIGNOR-273529 |
| PLK1 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 27003818 | SIGNOR-278190 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer206 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-249219 |
| PLK1 | phosphorylation up-regulates → | CENPQ PSer138 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265228 |
| PLK1 | phosphorylation up-regulates → | BORA PThr501 | phosphorylation down-regulates ⊣ | BORA | 18521620 | SIGNOR-178807 |
| PLK1 | phosphorylation up-regulates → | YBX1 PSer176 | phosphorylation up-regulates → | YBX1 | 36805592 | SIGNOR-279255 |
| PLK1 | phosphorylation up-regulates → | REST PSer1030 | phosphorylation down-regulates ⊣ | REST | 25453754 | SIGNOR-279380 |
| PLK1 | phosphorylation up-regulates → | SREBF1 PSer486 | phosphorylation up-regulates → | SREBF1 | 27579997 | SIGNOR-279383 |
| PLK1 | phosphorylation up-regulates → | BEX4 PThr107 | phosphorylation up-regulates → | BEX4 | 30367032 | SIGNOR-279550 |
| PLK1 | phosphorylation up-regulates → | STK38 PThr407 | phosphorylation down-regulates ⊣ | STK38 | 26057687 | SIGNOR-276915 |
| PLK1 | phosphorylation up-regulates → | TP73 PThr27 | phosphorylation down-regulates ⊣ | TP73 | 18418051 | SIGNOR-178253 |
| PLK1 | phosphorylation up-regulates → | PARP10 PThr601 | phosphorylation up-regulates → | PARP10 | 32060423 | SIGNOR-273728 |
| PLK1 | phosphorylation up-regulates → | TTK PThr594 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276221 |
| PLK1 | phosphorylation up-regulates → | KIF2C PSer715 | phosphorylation up-regulates → | KIF2C | 26206521 | SIGNOR-276931 |
| PLK1 | phosphorylation up-regulates → | TERF1 PSer435 | phosphorylation up-regulates → | TERF1 | 18625707 | SIGNOR-179461 |
| PLK1 | phosphorylation up-regulates → | CCNT1 PSer564 | phosphorylation down-regulates ⊣ | CCNT1 | 23977272 | SIGNOR-276501 |
| PLK1 | phosphorylation up-regulates → | TNKS PThr930 | phosphorylation up-regulates → | TNKS | 21818122 | SIGNOR-276243 |
| PLK1 | phosphorylation up-regulates → | PINX1 PSer226 | phosphorylation down-regulates ⊣ | PINX1 | 20573420 | SIGNOR-166325 |
| PLK1 | phosphorylation up-regulates → | USP16 PSer386 | phosphorylation up-regulates → | USP16 | 26323689 | SIGNOR-274015 |
| PLK1 | phosphorylation up-regulates → | CLSPN PSer30 | phosphorylation down-regulates ⊣ | CLSPN | 16885022 | SIGNOR-148447 |
| PLK1 | phosphorylation up-regulates → | PKMYT1 PThr495 | phosphorylation down-regulates ⊣ | PKMYT1 | 12738781 | SIGNOR-263097 |
| PLK1 | phosphorylation up-regulates → | TNKS PThr982 | phosphorylation up-regulates → | TNKS | 21818122 | SIGNOR-276241 |
| PLK1 | phosphorylation up-regulates → | CDC20 PSer170 | phosphorylation down-regulates ⊣ | CDC20 | 23643811 | SIGNOR-276493 |
| PLK1 | phosphorylation up-regulates → | PTPN1 PSer286 | phosphorylation up-regulates → | PTPN1 | 23348582 | SIGNOR-272990 |
| PLK1 | phosphorylation up-regulates → | CLSPN PSer30 | phosphorylation down-regulates ⊣ | CLSPN | 16885021 | SIGNOR-148442 |
| PLK1 | phosphorylation up-regulates → | RIOK2 PSer380 | phosphorylation up-regulates → | RIOK2 | 21880710 | SIGNOR-262938 |
| PLK1 | phosphorylation up-regulates → | TRIOBP PThr2229 | phosphorylation up-regulates → | TRIOBP | 22820163 | SIGNOR-198353 |
| PLK1 | phosphorylation up-regulates → | G6PD PThr466 | phosphorylation up-regulates → | G6PD | 29138396 | SIGNOR-267581 |
| PLK1 | phosphorylation up-regulates → | KAT7 PSer57 | phosphorylation up-regulates → | KAT7 | 18250300 | SIGNOR-160751 |
| PLK1 | phosphorylation up-regulates → | STARD9 PSer312 | phosphorylation down-regulates ⊣ | STARD9 | 25501367 | SIGNOR-279804 |
| PLK1 | phosphorylation up-regulates → | TTK PSer362 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276200 |
| PLK1 | phosphorylation up-regulates → | CENPQ PThr135 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265234 |
| PLK1 | phosphorylation up-regulates → | DVL2 PThr206 | phosphorylation up-regulates → | DVL2 | 20823832 | SIGNOR-167858 |
| PLK1 | phosphorylation up-regulates → | ATXN10 PThr82 | phosphorylation down-regulates ⊣ | ATXN10 | 21857149 | SIGNOR-176126 |
| PLK1 | phosphorylation up-regulates → | CENPQ PSer249 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265230 |
| PLK1 | phosphorylation up-regulates → | SUGT1 PSer331 | phosphorylation up-regulates → | SUGT1 | 22869522 | SIGNOR-265222 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer53 | phosphorylation down-regulates ⊣ | WEE1 | 15350223 | SIGNOR-128643 |
| PLK1 | phosphorylation up-regulates → | YBX1 PSer174 | phosphorylation up-regulates → | YBX1 | 36805592 | SIGNOR-279254 |
| PLK1 | phosphorylation up-regulates → | CCNB1 PSer126 | phosphorylation up-regulates → | CCNB1 | 11242082 | SIGNOR-105707 |
| PLK1 | phosphorylation up-regulates → | NCAPH2 PSer288 | phosphorylation up-regulates → | NCAPH2 | 28717250 | SIGNOR-278419 |
| PLK1 | phosphorylation up-regulates → | SREBF1 PSer467 | phosphorylation up-regulates → | SREBF1 | 27579997 | SIGNOR-279382 |
| PLK1 | phosphorylation up-regulates → | ZMYM2 PSer309 | phosphorylation down-regulates ⊣ | ZMYM2 | 25855382 | SIGNOR-275560 |
| PLK1 | phosphorylation up-regulates → | AXIN2 PSer311 | phosphorylation up-regulates → | AXIN2 | 26438599 | SIGNOR-277180 |
| PLK1 | phosphorylation up-regulates → | SUN1 PSer138 | phosphorylation down-regulates ⊣ | SUN1 | 25482198 | SIGNOR-263098 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer206 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-102494 |
| PLK1 | phosphorylation up-regulates → | G6PD PThr406 | phosphorylation up-regulates → | G6PD | 29138396 | SIGNOR-267580 |
| PLK1 | phosphorylation up-regulates → | CENPU PThr78 | phosphorylation down-regulates ⊣ | CENPU | 17081991 | SIGNOR-150457 |
| PLK1 | phosphorylation up-regulates → | RAF1 PSer339 | phosphorylation up-regulates → | RAF1 | 27003818 | SIGNOR-278191 |
| PLK1 | phosphorylation up-regulates → | MAD2L1BP PSer102 | phosphorylation down-regulates ⊣ | MAD2L1BP | 31118282 | SIGNOR-265970 |
| PLK1 | phosphorylation up-regulates → | BUB1B PThr792 | phosphorylation up-regulates → | BUB1B | 17376779 | SIGNOR-153867 |
| PLK1 | phosphorylation up-regulates → | CLIP1 PSer312 | phosphorylation down-regulates ⊣ | CLIP1 | 24451569 | SIGNOR-264575 |
| PLK1 | phosphorylation up-regulates → | TOP2A PSer1525 | phosphorylation up-regulates → | TOP2A | 19098900 | SIGNOR-182844 |
| PLK1 | phosphorylation up-regulates → | BORA PThr501 | phosphorylation down-regulates ⊣ | BORA | 18378770 | SIGNOR-178154 |
| PLK1 | phosphorylation up-regulates → | ARHGDIA PThr91 | phosphorylation up-regulates → | ARHGDIA | 38355643 | SIGNOR-277882 |
| PLK1 | phosphorylation up-regulates → | RACGAP1 PSer214 | phosphorylation up-regulates → | RACGAP1 | 19468302 | SIGNOR-185754 |
| PLK1 | phosphorylation up-regulates → | RIOK2 PSer548 | phosphorylation up-regulates → | RIOK2 | 21880710 | SIGNOR-262939 |
| PLK1 | phosphorylation up-regulates → | KIF2C PSer621 | phosphorylation down-regulates ⊣ | KIF2C | 25504441 | SIGNOR-276862 |
| PLK1 | phosphorylation up-regulates → | TTK PSer345 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276198 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PThr203 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-249220 |
| PLK1 | phosphorylation up-regulates → | TNKS PThr839 | phosphorylation up-regulates → | TNKS | 21818122 | SIGNOR-276245 |
| PLK1 | phosphorylation up-regulates → | CENPQ PThr256 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265229 |
| PLK1 | phosphorylation up-regulates → | KIF2B PThr125 | phosphorylation up-regulates → | KIF2B | 22535524 | SIGNOR-252049 |
| PLK1 | phosphorylation up-regulates → | PKMYT1 PSer426 | phosphorylation down-regulates ⊣ | PKMYT1 | 12738781 | SIGNOR-263096 |
| PLK1 | phosphorylation up-regulates → | IKBKB PSer733 | phosphorylation down-regulates ⊣ | IKBKB | 18957422 | SIGNOR-181798 |
| PLK1 | phosphorylation up-regulates → | ESPL1 PThr1363 | phosphorylation down-regulates ⊣ | ESPL1 | 17974570 | SIGNOR-276083 |
| PLK1 | phosphorylation up-regulates → | CEP192 PThr44 | phosphorylation up-regulates → | CEP192 | 26012549 | SIGNOR-266405 |
| PLK1 | phosphorylation up-regulates → | CASP8 PSer305 | phosphorylation down-regulates ⊣ | CASP8 | 24484936 | SIGNOR-272989 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer205 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-249218 |
| PLK1 | phosphorylation up-regulates → | RAN PSer135 | phosphorylation up-regulates → | RAN | 16930555 | SIGNOR-149073 |
| PLK1 | phosphorylation up-regulates → | RAP1GAP PSer525 | phosphorylation down-regulates ⊣ | RAP1GAP | 25329897 | SIGNOR-205577 |
| PLK1 | phosphorylation up-regulates → | NPM1 PSer4 | phosphorylation up-regulates → | NPM1 | 15190079 | SIGNOR-125666 |
| PLK1 | phosphorylation up-regulates → | TTK PThr458 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276222 |
| PLK1 | phosphorylation up-regulates → | TTK PSer37 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276206 |
| PLK1 | phosphorylation up-regulates → | CENPQ PSer255 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265226 |
| PLK1 | phosphorylation up-regulates → | TRIOBP PThr447 | phosphorylation up-regulates → | TRIOBP | 22820163 | SIGNOR-198357 |
| PLK1 | phosphorylation up-regulates → | VIM PSer83 | phosphorylation up-regulates → | VIM | 18056432 | SIGNOR-159386 |
| PLK1 | phosphorylation up-regulates → | CCNB1 PSer133 | phosphorylation up-regulates → | CCNB1 | 11242082 | SIGNOR-105715 |
| PLK1 | phosphorylation up-regulates → | KIF2C PSer632 | phosphorylation up-regulates → | KIF2C | 25504441 | SIGNOR-276863 |
| PLK1 | phosphorylation up-regulates → | TPT1 PSer64 | phosphorylation down-regulates ⊣ | TPT1 | 12167714 | SIGNOR-91348 |
| PLK1 | phosphorylation up-regulates → | CLASP2 PSer1234 | phosphorylation up-regulates → | CLASP2 | 23045552 | SIGNOR-278321 |
| PLK1 | phosphorylation up-regulates → | NINL PSer88 | phosphorylation down-regulates ⊣ | NINL | 12852856 | SIGNOR-103356 |
| PLK1 | phosphorylation up-regulates → | SUZ12 PSer546 | phosphorylation down-regulates ⊣ | SUZ12 | 25855382 | SIGNOR-275556 |
| PLK1 | phosphorylation up-regulates → | TTK PThr564 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276214 |
| PLK1 | phosphorylation up-regulates → | FOXM1 PSer739 | phosphorylation up-regulates → | FOXM1 | 19737929 | SIGNOR-187892 |
| PLK1 | phosphorylation up-regulates → | SREBF1 PThr424 | phosphorylation up-regulates → | SREBF1 | 27579997 | SIGNOR-279381 |
| PLK1 | phosphorylation up-regulates → | ZMYM2 PSer305 | phosphorylation down-regulates ⊣ | ZMYM2 | 25855382 | SIGNOR-275558 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer205 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-102490 |
| PLK1 | phosphorylation up-regulates → | NEDD1 PThr382 | phosphorylation up-regulates → | NEDD1 | 19509060 | SIGNOR-272993 |
| PLK1 | phosphorylation up-regulates → | STK38 PThr7 | phosphorylation down-regulates ⊣ | STK38 | 26057687 | SIGNOR-278420 |
| PLK1 | phosphorylation up-regulates → | STK38 PThr407 | phosphorylation down-regulates ⊣ | STK38 | 26057687 | SIGNOR-278421 |
| PLK1 | phosphorylation up-regulates → | STK38 PThr183 | phosphorylation down-regulates ⊣ | STK38 | 26057687 | SIGNOR-278422 |
| PLK1 | phosphorylation up-regulates → | STK38 PThr183 | phosphorylation down-regulates ⊣ | STK38 | 26057687 | SIGNOR-276913 |
| PLK1 | phosphorylation up-regulates → | LRRK1 PSer1817 | phosphorylation up-regulates → | LRRK1 | 26192437 | SIGNOR-275467 |
| PLK1 | phosphorylation up-regulates → | TTK PThr12 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276202 |
| PLK1 | phosphorylation up-regulates → | KIZ PThr379 | phosphorylation up-regulates → | KIZ | 16980960 | SIGNOR-149630 |
| PLK1 | phosphorylation up-regulates → | STK38 PThr7 | phosphorylation down-regulates ⊣ | STK38 | 26057687 | SIGNOR-276914 |
| PLK1 | phosphorylation up-regulates → | NINL PThr161 | phosphorylation down-regulates ⊣ | NINL | 12852856 | SIGNOR-103364 |
| PLK1 | phosphorylation up-regulates → | TTK PSer108 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276220 |
| PLK1 | phosphorylation up-regulates → | PINX1 PThr141 | phosphorylation down-regulates ⊣ | PINX1 | 20573420 | SIGNOR-166329 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer53 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-276040 |
| PLK1 | phosphorylation up-regulates → | NEDD1 PSer637 | phosphorylation up-regulates → | NEDD1 | 19509060 | SIGNOR-272991 |
| PLK1 | phosphorylation up-regulates → | TTK PThr46 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276218 |
| PLK1 | phosphorylation up-regulates → | TP53BP1 PSer1618 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264413 |
| PLK1 | phosphorylation up-regulates → | WDCP PSer695 | phosphorylation up-regulates → | WDCP | 30297404 | SIGNOR-273731 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PThr203 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-102498 |
| PLK1 | phosphorylation up-regulates → | IKBKB PSer740 | phosphorylation down-regulates ⊣ | IKBKB | 18957422 | SIGNOR-181802 |
| PLK1 | phosphorylation up-regulates → | IRS1 PSer24 | phosphorylation down-regulates ⊣ | IRS1 | 15849359 | SIGNOR-135688 |
| PLK1 | phosphorylation up-regulates → | MAD1L1 PThr680 | phosphorylation up-regulates → | MAD1L1 | 18922800 | SIGNOR-276173 |
| PLK1 | phosphorylation up-regulates → | NOTCH1 PSer1791 | phosphorylation down-regulates ⊣ | NOTCH1 | 31597699 | SIGNOR-277491 |
| PLK1 | phosphorylation up-regulates → | KIF2C PSer633 | phosphorylation up-regulates → | KIF2C | 25504441 | SIGNOR-276861 |
| PLK1 | phosphorylation up-regulates → | RACGAP1 PSer170 | phosphorylation up-regulates → | RACGAP1 | 19468302 | SIGNOR-185750 |
| PLK1 | phosphorylation up-regulates → | TTK PSer214 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276216 |
| PLK1 | phosphorylation up-regulates → | KLF4 PSer234 | phosphorylation up-regulates → | KLF4 | 31281496 | SIGNOR-277463 |
| PLK1 | phosphorylation up-regulates → | STARD9 PSer312 | phosphorylation down-regulates ⊣ | STARD9 | 25501367 | SIGNOR-279806 |
| PLK1 | phosphorylation up-regulates → | PINX1 PSer117 | phosphorylation down-regulates ⊣ | PINX1 | 20573420 | SIGNOR-166321 |
| PLK1 | phosphorylation up-regulates → | RSF1 PSer1359 | phosphorylation up-regulates → | RSF1 | 26259146 | SIGNOR-273590 |
| PLK1 | phosphorylation up-regulates → | SUZ12 PSer539 | phosphorylation down-regulates ⊣ | SUZ12 | 25855382 | SIGNOR-275557 |
| PLK1 | phosphorylation up-regulates → | SUZ12 PSer541 | phosphorylation down-regulates ⊣ | SUZ12 | 25855382 | SIGNOR-275555 |
| PLK1 | phosphorylation up-regulates → | OPTN PSer177 | phosphorylation up-regulates → | OPTN | 22365832 | SIGNOR-196367 |
| PLK1 | phosphorylation up-regulates → | BUB1B PThr680 | phosphorylation up-regulates → | BUB1B | 23079597 | SIGNOR-199222 |
| PLK1 | phosphorylation up-regulates → | NUDC PSer326 | phosphorylation up-regulates → | NUDC | 12852857 | SIGNOR-103407 |
| PLK1 | phosphorylation up-regulates → | WDCP PSer686 | phosphorylation up-regulates → | WDCP | 30297404 | SIGNOR-273730 |
| PLK1 | phosphorylation up-regulates → | NOTCH1 PSer2439 | phosphorylation down-regulates ⊣ | NOTCH1 | 31597699 | SIGNOR-277490 |
| PLK1 | phosphorylation up-regulates → | AHR PSer489 | phosphorylation down-regulates ⊣ | AHR | 37988371 | SIGNOR-277885 |
| PLK1 | phosphorylation up-regulates → | CTNNB1 PSer718 | phosphorylation down-regulates ⊣ | CTNNB1 | 19001871 | SIGNOR-182150 |
| PLK1 | phosphorylation up-regulates → | RACGAP1 PSer157 | phosphorylation up-regulates → | RACGAP1 | 19468302 | SIGNOR-185746 |
| PLK1 | phosphorylation up-regulates → | CEP55 PSer436 | phosphorylation up-regulates → | CEP55 | 16198290 | SIGNOR-140898 |
| PLK1 | phosphorylation up-regulates → | DNMT3A PSer393 | phosphorylation down-regulates ⊣ | DNMT3A | 34051063 | SIGNOR-279552 |
| PLK1 | phosphorylation up-regulates → | CENPQ PSer248 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265227 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer53 | phosphorylation down-regulates ⊣ | WEE1 | 16085715 | SIGNOR-139477 |
| PLK1 | phosphorylation up-regulates → | CHEK2 PThr26 | phosphorylation down-regulates ⊣ | CHEK2 | 12493754 | SIGNOR-249180 |
| PLK1 | phosphorylation up-regulates → | MRE11 PSer649 | phosphorylation down-regulates ⊣ | MRE11 | 28512243 | SIGNOR-265943 |
| PLK1 | phosphorylation up-regulates → | IKBKB PSer750 | phosphorylation down-regulates ⊣ | IKBKB | 18957422 | SIGNOR-181806 |
| PLK1 | phosphorylation up-regulates → | RAD51 PSer14 | phosphorylation up-regulates → | RAD51 | 26811421 | SIGNOR-278187 |
| PLK1 | phosphorylation up-regulates → | NEK9 PThr210 | phosphorylation up-regulates → | NEK9 | 21642957 | SIGNOR-273888 |
| PLK1 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 19889641 | SIGNOR-189045 |
| PLK1 | phosphorylation up-regulates → | CDC6 PThr37 | phosphorylation up-regulates → | CDC6 | 21041660 | SIGNOR-169184 |
| PLK1 | phosphorylation up-regulates → | WEE1 PSer53 | phosphorylation down-regulates ⊣ | WEE1 | 15070733 | SIGNOR-123832 |
| PLK1 | phosphorylation up-regulates → | CEP68 PSer332 | phosphorylation down-regulates ⊣ | CEP68 | 25503564 | SIGNOR-275621 |
| PLK1 | phosphorylation up-regulates → | PLEKHG6 PThr574 | phosphorylation up-regulates → | PLEKHG6 | 18694934 | SIGNOR-179954 |
| PLK1 | phosphorylation up-regulates → | NUDC PSer274 | phosphorylation up-regulates → | NUDC | 12852857 | SIGNOR-103403 |
| PLK1 | phosphorylation up-regulates → | STK3 PSer15 | phosphorylation down-regulates ⊣ | STK3 | 37739411 | SIGNOR-277904 |
| PLK1 | phosphorylation up-regulates → | MAP9 PSer289 | phosphorylation up-regulates → | MAP9 | 20615875 | SIGNOR-166564 |
| PLK1 | phosphorylation up-regulates → | TTK PThr371 | phosphorylation up-regulates → | TTK | 26119734 | SIGNOR-276210 |
| PLK1 | phosphorylation up-regulates → | CENPQ PSer253 | phosphorylation down-regulates ⊣ | CENPQ | 25670858 | SIGNOR-265232 |
| PLK1 | phosphorylation up-regulates → | NINL PSer686 | phosphorylation down-regulates ⊣ | NINL | 12852856 | SIGNOR-103348 |
| PLK1 | phosphorylation up-regulates → | ANAPC1 PSer355 | phosphorylation up-regulates → | ANAPC1 | 14657031 | SIGNOR-119881 |
| PLK1 | phosphorylation up-regulates → | SRI PThr155 | phosphorylation down-regulates ⊣ | SRI | 24427308 | SIGNOR-203732 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265231 |
| PLK1 | phosphorylation → unknown | BRCA2 | SIGNOR-249221 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276197 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | SMAD4 | SIGNOR-277591 |
| PLK1 | phosphorylation → up-regulates activity | SVIL | SIGNOR-273729 |
| PLK1 | phosphorylation → down-regulates activity | CELSR1 | SIGNOR-279094 |
| PLK1 | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272992 |
| PLK1 | phosphorylation → up-regulates activity | RBBP8 | SIGNOR-279253 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276204 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | ZMYM2 | SIGNOR-275559 |
| PLK1 | phosphorylation → up-regulates activity | ARHGDIA | SIGNOR-277883 |
| PLK1 | phosphorylation → up-regulates | RACGAP1 | SIGNOR-185758 |
| PLK1 | phosphorylation → up-regulates | YY1 | SIGNOR-200087 |
| PLK1 | phosphorylation → unknown | PKMYT1 | SIGNOR-249208 |
| PLK1 | phosphorylation down-regulates | PINX1 | SIGNOR-166333 |
| PLK1 | phosphorylation → down-regulates activity | SUZ12 | SIGNOR-278423 |
| PLK1 | phosphorylation down-regulates | ATXN10 | SIGNOR-176122 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265233 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276212 |
| PLK1 | phosphorylation → up-regulates | TOP2A | SIGNOR-160237 |
| PLK1 | phosphorylation down-regulates | TPT1 | SIGNOR-91344 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276208 |
| PLK1 | phosphorylation → up-regulates activity | USP16 | SIGNOR-274016 |
| PLK1 | phosphorylation → up-regulates | CDC25C | SIGNOR-115993 |
| PLK1 | phosphorylation → up-regulates quantity by stabilization | TNKS | SIGNOR-276244 |
| PLK1 | phosphorylation → up-regulates activity | EME1 | SIGNOR-280068 |
| PLK1 | phosphorylation → down-regulates activity | PTEN | SIGNOR-280070 |
| PLK1 | phosphorylation → up-regulates activity | STK3 | SIGNOR-280071 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | TSC1 | SIGNOR-280072 |
| PLK1 | phosphorylation → down-regulates activity | NINL | SIGNOR-103352 |
| PLK1 | phosphorylation → up-regulates quantity by stabilization | TNKS | SIGNOR-276242 |
| PLK1 | phosphorylation → down-regulates activity | FADD | SIGNOR-168204 |
| PLK1 | phosphorylation down-regulates | PINX1 | SIGNOR-166317 |
| PLK1 | phosphorylation → up-regulates activity | USP16 | SIGNOR-274017 |
| PLK1 | phosphorylation → up-regulates | FOXM1 | SIGNOR-187888 |
| PLK1 | phosphorylation → up-regulates | TOP2A | SIGNOR-160233 |
| PLK1 | phosphorylation → up-regulates | GTSE1 | SIGNOR-166417 |
| PLK1 | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272994 |
| PLK1 | phosphorylation → up-regulates | BUB1B | SIGNOR-157646 |
| PLK1 | phosphorylation → up-regulates activity | USP16 | SIGNOR-278270 |
| PLK1 | phosphorylation → up-regulates activity | RIOK2 | SIGNOR-262937 |
| PLK1 | phosphorylation → up-regulates | MDM2 | SIGNOR-188471 |
| PLK1 | phosphorylation → unknown | PKMYT1 | SIGNOR-249207 |
| PLK1 | phosphorylation → up-regulates | PIN1 | SIGNOR-139919 |
| PLK1 | phosphorylation → up-regulates | CHEK2 | SIGNOR-96637 |
| PLK1 | phosphorylation → up-regulates | BUB1B | SIGNOR-153863 |
| PLK1 | phosphorylation → down-regulates activity | CDCA5 | SIGNOR-276122 |
| PLK1 | phosphorylation → up-regulates | MDM2 | SIGNOR-94272 |
| PLK1 | phosphorylation → up-regulates activity | CCNB1 | SIGNOR-105711 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276219 |
| PLK1 | phosphorylation → down-regulates activity | BRCA2 | SIGNOR-102502 |
| PLK1 | phosphorylation → up-regulates | BIRC5 | SIGNOR-170460 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276199 |
| PLK1 | phosphorylation down-regulates | FBXO5 | SIGNOR-129813 |
| PLK1 | phosphorylation → down-regulates activity | ESPL1 | SIGNOR-276082 |
| PLK1 | phosphorylation down-regulates | BORA | SIGNOR-178150 |
| PLK1 | phosphorylation → up-regulates activity | PRKN | SIGNOR-276938 |
| PLK1 | phosphorylation down-regulates | CENPU | SIGNOR-150453 |
| PLK1 | phosphorylation → unknown | BRCA2 | SIGNOR-249217 |
| PLK1 | phosphorylation down-regulates | BORA | SIGNOR-178803 |
| PLK1 | phosphorylation → down-regulates activity | SNCB | SIGNOR-176079 |
| PLK1 | phosphorylation → up-regulates activity | CCNB1 | SIGNOR-105719 |
| PLK1 | phosphorylation → up-regulates activity | TOPORS | SIGNOR-185838 |
| PLK1 | phosphorylation → up-regulates | CLIP1 | SIGNOR-167172 |
| PLK1 | phosphorylation down-regulates | WEE1 | SIGNOR-139473 |
| PLK1 | phosphorylation → up-regulates activity | KIF2A | SIGNOR-278380 |
| PLK1 | phosphorylation → up-regulates activity | KIF2B | SIGNOR-252050 |
| PLK1 | phosphorylation → up-regulates activity | PRKDC | SIGNOR-278188 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CDH1 | SIGNOR-274054 |
| PLK1 | phosphorylation → down-regulates activity | BRCA2 | SIGNOR-102486 |
| PLK1 | phosphorylation → up-regulates | DCTN1 | SIGNOR-167281 |
| PLK1 | phosphorylation down-regulates | HSF1 | SIGNOR-180915 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | TEX14 | SIGNOR-273529 |
| PLK1 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-278190 |
| PLK1 | phosphorylation → unknown | BRCA2 | SIGNOR-249219 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265228 |
| PLK1 | phosphorylation down-regulates | BORA | SIGNOR-178807 |
| PLK1 | phosphorylation → up-regulates activity | MYC | SIGNOR-243522 |
| PLK1 | phosphorylation → up-regulates activity | BUB1 | SIGNOR-279251 |
| PLK1 | phosphorylation → up-regulates quantity | YBX1 | SIGNOR-279255 |
| PLK1 | phosphorylation → up-regulates activity | RPTOR | SIGNOR-279346 |
| PLK1 | phosphorylation → down-regulates activity | REST | SIGNOR-279380 |
| PLK1 | phosphorylation → up-regulates activity | SREBF1 | SIGNOR-279383 |
| PLK1 | phosphorylation → up-regulates activity | BEX4 | SIGNOR-279550 |
| PLK1 | phosphorylation → down-regulates quantity | GORASP1 | SIGNOR-279554 |
| PLK1 | phosphorylation → down-regulates activity | STK38 | SIGNOR-276915 |
| PLK1 | phosphorylation → down-regulates activity | KIF4A | SIGNOR-280069 |
| PLK1 | phosphorylation → up-regulates activity | KIF2C | SIGNOR-278908 |
| PLK1 | phosphorylation down-regulates | TP73 | SIGNOR-178253 |
| PLK1 | phosphorylation → up-regulates activity | PARP10 | SIGNOR-273728 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276221 |
| PLK1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-279095 |
| PLK1 | phosphorylation → up-regulates activity | KIF2C | SIGNOR-276931 |
| PLK1 | phosphorylation → up-regulates | TERF1 | SIGNOR-179461 |
| PLK1 | phosphorylation → down-regulates activity | CCNT1 | SIGNOR-276501 |
| PLK1 | phosphorylation → up-regulates quantity by stabilization | TNKS | SIGNOR-276243 |
| PLK1 | phosphorylation down-regulates | PINX1 | SIGNOR-166325 |
| PLK1 | phosphorylation → up-regulates activity | USP16 | SIGNOR-274015 |
| PLK1 | phosphorylation down-regulates | CLSPN | SIGNOR-148447 |
| PLK1 | phosphorylation → down-regulates activity | PKMYT1 | SIGNOR-263097 |
| PLK1 | phosphorylation → up-regulates quantity by stabilization | TNKS | SIGNOR-276241 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CDC20 | SIGNOR-276493 |
| PLK1 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-272990 |
| PLK1 | phosphorylation down-regulates | CLSPN | SIGNOR-148442 |
| PLK1 | phosphorylation → up-regulates activity | RIOK2 | SIGNOR-262938 |
| PLK1 | phosphorylation → up-regulates | TRIOBP | SIGNOR-198353 |
| PLK1 | phosphorylation → up-regulates activity | G6PD | SIGNOR-267581 |
| PLK1 | phosphorylation → up-regulates | KAT7 | SIGNOR-160751 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | STARD9 | SIGNOR-279804 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276200 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265234 |
| PLK1 | phosphorylation → up-regulates | DVL2 | SIGNOR-167858 |
| PLK1 | phosphorylation down-regulates | ATXN10 | SIGNOR-176126 |
| PLK1 | phosphorylation → up-regulates activity | ECT2 | SIGNOR-279553 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265230 |
| PLK1 | phosphorylation → down-regulates activity | NOTCH1 | SIGNOR-279096 |
| PLK1 | phosphorylation → up-regulates activity | SUGT1 | SIGNOR-265222 |
| PLK1 | phosphorylation down-regulates | WEE1 | SIGNOR-128643 |
| PLK1 | phosphorylation → up-regulates activity | CNTROB | SIGNOR-279551 |
| PLK1 | phosphorylation → up-regulates quantity | YBX1 | SIGNOR-279254 |
| PLK1 | phosphorylation → up-regulates activity | CCNB1 | SIGNOR-105707 |
| PLK1 | phosphorylation → up-regulates activity | NCAPH2 | SIGNOR-278419 |
| PLK1 | phosphorylation → up-regulates activity | SREBF1 | SIGNOR-279382 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | ZMYM2 | SIGNOR-275560 |
| PLK1 | phosphorylation → up-regulates activity | AXIN2 | SIGNOR-277180 |
| PLK1 | phosphorylation → down-regulates activity | SUN1 | SIGNOR-263098 |
| PLK1 | phosphorylation → down-regulates activity | BRCA2 | SIGNOR-102494 |
| PLK1 | phosphorylation → up-regulates activity | G6PD | SIGNOR-267580 |
| PLK1 | phosphorylation down-regulates | CENPU | SIGNOR-150457 |
| PLK1 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-278191 |
| PLK1 | phosphorylation → down-regulates activity | MAD2L1BP | SIGNOR-265970 |
| PLK1 | phosphorylation → down-regulates activity | NUMA1 | SIGNOR-279345 |
| PLK1 | phosphorylation → up-regulates activity | SPAG5 | SIGNOR-279423 |
| PLK1 | phosphorylation → up-regulates | BUB1B | SIGNOR-153867 |
| PLK1 | phosphorylation → down-regulates activity | CLIP1 | SIGNOR-264575 |
| PLK1 | phosphorylation → up-regulates | TOP2A | SIGNOR-182844 |
| PLK1 | phosphorylation → up-regulates activity | RANBP1 | SIGNOR-279751 |
| PLK1 | phosphorylation down-regulates | BORA | SIGNOR-178154 |
| PLK1 | phosphorylation down-regulates | ZMYM2 | SIGNOR-278491 |
| PLK1 | phosphorylation → up-regulates activity | ARHGDIA | SIGNOR-277882 |
| PLK1 | phosphorylation → up-regulates | RACGAP1 | SIGNOR-185754 |
| PLK1 | phosphorylation → up-regulates activity | RIOK2 | SIGNOR-262939 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | KIF2C | SIGNOR-276862 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276198 |
| PLK1 | phosphorylation → unknown | BRCA2 | SIGNOR-249220 |
| PLK1 | phosphorylation → up-regulates quantity by stabilization | TNKS | SIGNOR-276245 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265229 |
| PLK1 | phosphorylation → up-regulates activity | KIF2B | SIGNOR-252049 |
| PLK1 | phosphorylation → down-regulates activity | PKMYT1 | SIGNOR-263096 |
| PLK1 | phosphorylation down-regulates | IKBKB | SIGNOR-181798 |
| PLK1 | phosphorylation → down-regulates activity | ESPL1 | SIGNOR-276083 |
| PLK1 | phosphorylation → up-regulates activity | CEP192 | SIGNOR-266405 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CASP8 | SIGNOR-272989 |
| PLK1 | phosphorylation → unknown | BRCA2 | SIGNOR-249218 |
| PLK1 | phosphorylation → up-regulates | RAN | SIGNOR-149073 |
| PLK1 | phosphorylation down-regulates | RAP1GAP | SIGNOR-205577 |
| PLK1 | phosphorylation → up-regulates activity | CDC25B | SIGNOR-267560 |
| PLK1 | phosphorylation → up-regulates | NPM1 | SIGNOR-125666 |
| PLK1 | phosphorylation → up-regulates activity | KIF20A | SIGNOR-278201 |
| PLK1 | phosphorylation → down-regulates activity | PRC1 | SIGNOR-279645 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | TEX14 | SIGNOR-279646 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276222 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276206 |
| PLK1 | phosphorylation → down-regulates activity | NUP35 | SIGNOR-279252 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265226 |
| PLK1 | phosphorylation → up-regulates | TRIOBP | SIGNOR-198357 |
| PLK1 | phosphorylation → up-regulates | VIM | SIGNOR-159386 |
| PLK1 | phosphorylation → up-regulates activity | CCNB1 | SIGNOR-105715 |
| PLK1 | phosphorylation → up-regulates activity | KIF2C | SIGNOR-276863 |
| PLK1 | phosphorylation down-regulates | TPT1 | SIGNOR-91348 |
| PLK1 | phosphorylation → up-regulates activity | CLASP2 | SIGNOR-278321 |
| PLK1 | phosphorylation → down-regulates activity | NINL | SIGNOR-103356 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | SUZ12 | SIGNOR-275556 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276214 |
| PLK1 | phosphorylation → up-regulates activity | CEP85 | SIGNOR-278367 |
| PLK1 | phosphorylation → up-regulates | FOXM1 | SIGNOR-187892 |
| PLK1 | phosphorylation → up-regulates activity | SREBF1 | SIGNOR-279381 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | ZMYM2 | SIGNOR-275558 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-278246 |
| PLK1 | phosphorylation → down-regulates activity | BRCA2 | SIGNOR-102490 |
| PLK1 | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272993 |
| PLK1 | phosphorylation → down-regulates activity | STK38 | SIGNOR-278420 |
| PLK1 | phosphorylation → down-regulates activity | STK38 | SIGNOR-278421 |
| PLK1 | phosphorylation → down-regulates activity | STK38 | SIGNOR-278422 |
| PLK1 | phosphorylation → down-regulates activity | STK38 | SIGNOR-276913 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CDH1 | SIGNOR-274053 |
| PLK1 | phosphorylation → up-regulates activity | LRRK1 | SIGNOR-275467 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276202 |
| PLK1 | phosphorylation → up-regulates | KIZ | SIGNOR-149630 |
| PLK1 | phosphorylation → down-regulates activity | STK38 | SIGNOR-276914 |
| PLK1 | phosphorylation → down-regulates activity | NINL | SIGNOR-103364 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276220 |
| PLK1 | phosphorylation down-regulates | PINX1 | SIGNOR-166329 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | WEE1 | SIGNOR-276040 |
| PLK1 | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272991 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276218 |
| PLK1 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264413 |
| PLK1 | phosphorylation → up-regulates activity | WDCP | SIGNOR-273731 |
| PLK1 | phosphorylation → up-regulates activity | HASPIN | SIGNOR-275421 |
| PLK1 | phosphorylation → down-regulates activity | BRCA2 | SIGNOR-102498 |
| PLK1 | phosphorylation down-regulates | IKBKB | SIGNOR-181802 |
| PLK1 | phosphorylation → up-regulates quantity by stabilization | TNKS | SIGNOR-279752 |
| PLK1 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-135688 |
| PLK1 | phosphorylation → up-regulates activity | MAD1L1 | SIGNOR-276173 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | NOTCH1 | SIGNOR-277491 |
| PLK1 | phosphorylation → up-regulates activity | KIF2C | SIGNOR-276861 |
| PLK1 | phosphorylation → up-regulates | RACGAP1 | SIGNOR-185750 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276216 |
| PLK1 | phosphorylation → up-regulates quantity by stabilization | KLF4 | SIGNOR-277463 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | STARD9 | SIGNOR-279806 |
| PLK1 | phosphorylation down-regulates | PINX1 | SIGNOR-166321 |
| PLK1 | phosphorylation → up-regulates activity | RSF1 | SIGNOR-273590 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | SUZ12 | SIGNOR-275557 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | SUZ12 | SIGNOR-275555 |
| PLK1 | phosphorylation → up-regulates | OPTN | SIGNOR-196367 |
| PLK1 | phosphorylation → up-regulates | BUB1B | SIGNOR-199222 |
| PLK1 | phosphorylation → up-regulates activity | NUDC | SIGNOR-103407 |
| PLK1 | phosphorylation → up-regulates activity | WDCP | SIGNOR-273730 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | NOTCH1 | SIGNOR-277490 |
| PLK1 | phosphorylation → down-regulates activity | AHR | SIGNOR-277885 |
| PLK1 | phosphorylation → unknown | CTNNB1 | SIGNOR-182150 |
| PLK1 | phosphorylation → up-regulates | RACGAP1 | SIGNOR-185746 |
| PLK1 | phosphorylation → up-regulates | CEP55 | SIGNOR-140898 |
| PLK1 | phosphorylation → down-regulates activity | DNMT3A | SIGNOR-279552 |
| PLK1 | phosphorylation down-regulates | FBXO5 | SIGNOR-142949 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265227 |
| PLK1 | phosphorylation down-regulates | WEE1 | SIGNOR-139477 |
| PLK1 | phosphorylation → unknown | CHEK2 | SIGNOR-249180 |
| PLK1 | phosphorylation → down-regulates activity | MRE11 | SIGNOR-265943 |
| PLK1 | phosphorylation down-regulates | IKBKB | SIGNOR-181806 |
| PLK1 | phosphorylation → up-regulates activity | RAD51 | SIGNOR-278187 |
| PLK1 | phosphorylation → up-regulates activity | NEK9 | SIGNOR-273888 |
| PLK1 | phosphorylation → down-regulates activity | SNCA | SIGNOR-189045 |
| PLK1 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-278269 |
| PLK1 | phosphorylation → up-regulates | CDC6 | SIGNOR-169184 |
| PLK1 | phosphorylation down-regulates | WEE1 | SIGNOR-123832 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CEP68 | SIGNOR-275621 |
| PLK1 | phosphorylation → up-regulates | PLEKHG6 | SIGNOR-179954 |
| PLK1 | phosphorylation → up-regulates activity | NUDC | SIGNOR-103403 |
| PLK1 | phosphorylation → down-regulates activity | STK3 | SIGNOR-277904 |
| PLK1 | phosphorylation → up-regulates | MAP9 | SIGNOR-166564 |
| PLK1 | phosphorylation → up-regulates activity | TTK | SIGNOR-276210 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CENPQ | SIGNOR-265232 |
| PLK1 | phosphorylation → down-regulates activity | NINL | SIGNOR-103348 |
| PLK1 | phosphorylation → up-regulates | ANAPC1 | SIGNOR-119881 |
| PLK1 | phosphorylation → unknown | SRI | SIGNOR-203732 |