Summary

Name PLK1
Full Name Serine/threonine-protein kinase PLK1
Synonyms Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13 | PLK
Primary ID P53350
Links - -
Type protein
Relations 186
Inhibitors 5-[6-[(4-methyl-1-piperazinyl)methyl]-1-benzimidazolyl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide; Rigosertib sodium; 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide; N-(4-methoxyphenyl)sulfonyl-N-[2-[2-(1-oxido-4-pyridin-1-iumyl)ethenyl]phenyl]acetamide; TAK-960; Volasertib; BI 2536
Function Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGO1

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png monoubiquitination PLK1 0.418
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation MAD2L1BP 0.379
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PINX1 0.374
Publications: 5 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAG2 0.725
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SNCB 0.323
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation WEE1 0.623
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CCNB1 0.919
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SNCA 0.359
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TOP2A 0.497
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAN 0.269
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RSF1 0.365
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CENPQ 0.567
Publications: 9 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SUN1 0.471
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDH1 0.304
Publications: 2
+ up-regulates img/direct-activation.png phosphorylation RACGAP1 0.664
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TP53BP1 0.62
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation RAD21 0.727
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation OPTN 0.519
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DCTN1 0.544
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRRK1 0.351
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation BRCA2 0.561
Publications: 5 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BRCA2 0.561
Publications: 5 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FADD 0.474
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CLIP1 0.691
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDC25C 0.797
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BIRC5 0.564
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KIF2B 0.647
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSF1 0.459
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SVIL 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.273
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MDM2 0.481
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NUDC 0.719
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.366
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP9 0.282
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CLSPN 0.765
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ZMYM2 0.39
Publications: 3
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CASP8 0.385
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation CLIP1 0.691
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PLK1 0.357
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation USP16 0.35
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SUGT1 0.449
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CEP68 0.455
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation RIOK2 0.447
Publications: 3 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ANAPC1 0.501
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NEDD1 0.605
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NPM1 0.437
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PKMYT1 0.703
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PKMYT1 0.703
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation GTSE1 0.724
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TERF1 0.387
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEP55 0.575
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TEX14 0.366
Publications: 1 Organism: Homo Sapiens
Tissue: Testis
+ down-regulates img/direct_inhibition.png phosphorylation TPT1 0.704
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLK1 0.526
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BORA 0.781
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAP1GAP 0.467
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SUZ12 0.375
Publications: 3
+ up-regulates img/direct-activation.png phosphorylation KAT7 0.522
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MRE11 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PIN1 0.437
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BUB1B 0.835
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NINL 0.687
Publications: 4 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation WDCP 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TOPORS 0.459
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CTNNB1 0.409
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOXM1 0.694
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation IKBKB 0.349
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ATXN10 0.365
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CENPU 0.731
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation VIM 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SRI 0.389
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DVL2 0.482
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLK1 0.644
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NEK9 0.589
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TRIOBP 0.34
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CHEK2 0.506
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation TP73 0.487
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDC6 0.589
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KIZ 0.497
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation YY1 0.407
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation G6PD 0.358
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CEP192 0.592
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLEKHG6 0.431
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PARP10 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation CHEK2 0.506
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLK1 0.297
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MYC 0.554
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLK1 0.781
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PLK1 0.314
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation FBXO5 0.775
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PLK1 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding PLK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PLK1 0.59
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PLK1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PLK1 0.383
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png chemical inhibition PLK1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding PLK1 0.46
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding PLK1 0.859
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PLK1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization ERCC6L 0.873
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PLK1 0.404
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PLK1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PLK1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PLK1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PLK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PLK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HASPIN 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png PLK1 0.609
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PLK1 0.484
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PLK1 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PLK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDC25B 0.656
Publications: 1
+ down-regulates img/direct_inhibition.png chemical inhibition PLK1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png TP53 0.601
Publications: 1 Organism: Homo Sapiens