Entity Details

Name PLK1
ID P53350
Role phosphatase
Enzymatic Domains
Protein kinase 53-305
PROSITE-ProRule
POLO box 1 410-488
PROSITE-ProRule
POLO box 2 510-592
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PLK1RAD21Ser175REIMREGsAFEDDDMdephosphorylation
down-regulates quantity by destabilization		15737063SIGNOR-275535
PLK1RAD21Ser454EPSRLQEsVMEASRTdephosphorylation
down-regulates quantity by destabilization		15737063SIGNOR-275536
PLK1STAG2Ser1137KRLRPEDsFMSVYPMdephosphorylation
down-regulates activity		15737063SIGNOR-275534
PLK1STAG2Ser1224PASIMDEsVLGVSMFdephosphorylation
down-regulates activity		15737063SIGNOR-275532
PLK1STAG2Thr1109MWLSREQtLHTPVMMdephosphorylation
down-regulates activity		15737063SIGNOR-275533
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PLK1dephosphorylation
down-regulates
⊣
RAD21
PSer175		dephosphorylation
up-regulates
→		RAD2115737063SIGNOR-275535
PLK1dephosphorylation
down-regulates
⊣
RAD21
PSer454		dephosphorylation
up-regulates
→		RAD2115737063SIGNOR-275536
PLK1dephosphorylation
down-regulates
⊣
STAG2
PSer1137		dephosphorylation
up-regulates
→		STAG215737063SIGNOR-275534
PLK1dephosphorylation
down-regulates
⊣
STAG2
PSer1224		dephosphorylation
up-regulates
→		STAG215737063SIGNOR-275532
PLK1dephosphorylation
down-regulates
⊣
STAG2
PThr1109		dephosphorylation
up-regulates
→		STAG215737063SIGNOR-275533
Regulator Mechanism/Effect Target SIGNOR-ID
PLK1dephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		RAD21SIGNOR-275535
PLK1dephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		RAD21SIGNOR-275536
PLK1dephosphorylation
→
down-regulates activity 		STAG2SIGNOR-275534
PLK1dephosphorylation
→
down-regulates activity 		STAG2SIGNOR-275532
PLK1dephosphorylation
→
down-regulates activity 		STAG2SIGNOR-275533