| Name | PLK1 |
| ID | P53350 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 53-305 PROSITE-ProRule
POLO box 1 410-488 PROSITE-ProRule
POLO box 2 510-592 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP4C | PLK1 | Ser137 | LELCRRRsLLELHKR | dephosphorylation down-regulates activity | 35546066 | SIGNOR-277076 |
| CHEK1 | PLK1 | Thr539 | INFFQDHtKLILCPL | phosphorylation down-regulates activity | 37596441 | SIGNOR-277914 |
| CHEK1 | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation up-regulates activity | 34197606 | SIGNOR-279501 |
| MAPKAPK2 | PLK1 | Ser326 | LTIPPRFsIAPSSLD | phosphorylation up-regulates | 18695677 | SIGNOR-179968 |
| MAP3K8 | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation up-regulates | 12207013 | SIGNOR-92274 |
| ABL1 | PLK1 | Tyr425 | SDKYGLGyQLCDNSV | phosphorylation up-regulates activity | 27899378 | SIGNOR-260935 |
| PRKDC | PLK1 | – | phosphorylation up-regulates activity | 25925375 | SIGNOR-279562 | |
| CHEK1 | PLK1 | Ser529 | ILHLSNGsVQINFFQ | phosphorylation down-regulates activity | 37596441 | SIGNOR-277913 |
| AURKA | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation up-regulates | 18615013 | SIGNOR-179422 |
| AURKB | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation up-regulates activity | 26206521 | SIGNOR-279358 |
| CDK2 | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation up-regulates activity | 33402344 | SIGNOR-280212 |
| PDPK1 | PLK1 | – | phosphorylation up-regulates activity | 23887393 | SIGNOR-243519 | |
| CHEK1 | PLK1 | Ser137 | LELCRRRsLLELHKR | phosphorylation up-regulates activity | 34197606 | SIGNOR-279502 |
| BORA | PLK1 | – | phosphorylation up-regulates | 18615013 | SIGNOR-179425 | |
| PIM1 | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation down-regulates activity | 24771642 | SIGNOR-279749 |
| ATM | PLK1 | – | phosphorylation down-regulates activity | 20042274 | SIGNOR-279793 | |
| PAK1 | PLK1 | Ser49 | EVLVDPRsRRRYVRG | phosphorylation up-regulates | 18427546 | SIGNOR-178353 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP4C | dephosphorylation down-regulates ⊣ | PLK1 PSer137 | dephosphorylation up-regulates → | PLK1 | 35546066 | SIGNOR-277076 |
| CHEK1 | phosphorylation up-regulates → | PLK1 PThr539 | phosphorylation down-regulates ⊣ | PLK1 | 37596441 | SIGNOR-277914 |
| CHEK1 | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation up-regulates → | PLK1 | 34197606 | SIGNOR-279501 |
| MAPKAPK2 | phosphorylation up-regulates → | PLK1 PSer326 | phosphorylation up-regulates → | PLK1 | 18695677 | SIGNOR-179968 |
| MAP3K8 | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation up-regulates → | PLK1 | 12207013 | SIGNOR-92274 |
| ABL1 | phosphorylation up-regulates → | PLK1 PTyr425 | phosphorylation up-regulates → | PLK1 | 27899378 | SIGNOR-260935 |
| CHEK1 | phosphorylation up-regulates → | PLK1 PSer529 | phosphorylation down-regulates ⊣ | PLK1 | 37596441 | SIGNOR-277913 |
| AURKA | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation up-regulates → | PLK1 | 18615013 | SIGNOR-179422 |
| AURKB | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation up-regulates → | PLK1 | 26206521 | SIGNOR-279358 |
| CDK2 | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation up-regulates → | PLK1 | 33402344 | SIGNOR-280212 |
| CHEK1 | phosphorylation up-regulates → | PLK1 PSer137 | phosphorylation up-regulates → | PLK1 | 34197606 | SIGNOR-279502 |
| PIM1 | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation down-regulates ⊣ | PLK1 | 24771642 | SIGNOR-279749 |
| PAK1 | phosphorylation up-regulates → | PLK1 PSer49 | phosphorylation up-regulates → | PLK1 | 18427546 | SIGNOR-178353 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP4C | dephosphorylation → down-regulates activity | PLK1 | SIGNOR-277076 |
| CHEK1 | phosphorylation → down-regulates activity | PLK1 | SIGNOR-277914 |
| CHEK1 | phosphorylation → up-regulates activity | PLK1 | SIGNOR-279501 |
| MAPKAPK2 | phosphorylation → up-regulates | PLK1 | SIGNOR-179968 |
| MAP3K8 | phosphorylation → up-regulates | PLK1 | SIGNOR-92274 |
| ABL1 | phosphorylation → up-regulates activity | PLK1 | SIGNOR-260935 |
| PRKDC | phosphorylation → up-regulates activity | PLK1 | SIGNOR-279562 |
| CHEK1 | phosphorylation → down-regulates activity | PLK1 | SIGNOR-277913 |
| AURKA | phosphorylation → up-regulates | PLK1 | SIGNOR-179422 |
| AURKB | phosphorylation → up-regulates activity | PLK1 | SIGNOR-279358 |
| CDK2 | phosphorylation → up-regulates activity | PLK1 | SIGNOR-280212 |
| PDPK1 | phosphorylation → up-regulates activity | PLK1 | SIGNOR-243519 |
| CHEK1 | phosphorylation → up-regulates activity | PLK1 | SIGNOR-279502 |
| BORA | phosphorylation → up-regulates | PLK1 | SIGNOR-179425 |
| PIM1 | phosphorylation → down-regulates activity | PLK1 | SIGNOR-279749 |
| ATM | phosphorylation → down-regulates activity | PLK1 | SIGNOR-279793 |
| PAK1 | phosphorylation → up-regulates | PLK1 | SIGNOR-178353 |