| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | PLK1 | Ser137 | LELCRRRsLLELHKR | phosphorylation up-regulates activity | 34197606 | SIGNOR-279502 |
| PPP4C | PLK1 | Ser137 | LELCRRRsLLELHKR | dephosphorylation down-regulates activity | 35546066 | SIGNOR-277076 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | PLK1 PSer137 | phosphorylation up-regulates → | PLK1 | 34197606 | SIGNOR-279502 |
| PPP4C | dephosphorylation down-regulates ⊣ | PLK1 PSer137 | dephosphorylation up-regulates → | PLK1 | 35546066 | SIGNOR-277076 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK1 | phosphorylation → up-regulates activity | PLK1 | SIGNOR-279502 |
| PPP4C | dephosphorylation → down-regulates activity | PLK1 | SIGNOR-277076 |
