| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | PLK1 | Ser529 | ILHLSNGsVQINFFQ | phosphorylation down-regulates activity | 37596441 | SIGNOR-277913 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | PLK1 PSer529 | phosphorylation down-regulates ⊣ | PLK1 | 37596441 | SIGNOR-277913 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK1 | phosphorylation → down-regulates activity | PLK1 | SIGNOR-277913 |