| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM1 | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation down-regulates activity | 24771642 | SIGNOR-279749 |
| CDK2 | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation up-regulates activity | 33402344 | SIGNOR-280212 |
| MAP3K8 | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation up-regulates | 12207013 | SIGNOR-92274 |
| AURKA | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation up-regulates | 18615013 | SIGNOR-179422 |
| CHEK1 | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation up-regulates activity | 34197606 | SIGNOR-279501 |
| AURKB | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation up-regulates activity | 26206521 | SIGNOR-279358 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM1 | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation down-regulates ⊣ | PLK1 | 24771642 | SIGNOR-279749 |
| CDK2 | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation up-regulates → | PLK1 | 33402344 | SIGNOR-280212 |
| MAP3K8 | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation up-regulates → | PLK1 | 12207013 | SIGNOR-92274 |
| AURKA | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation up-regulates → | PLK1 | 18615013 | SIGNOR-179422 |
| CHEK1 | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation up-regulates → | PLK1 | 34197606 | SIGNOR-279501 |
| AURKB | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation up-regulates → | PLK1 | 26206521 | SIGNOR-279358 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PIM1 | phosphorylation → down-regulates activity | PLK1 | SIGNOR-279749 |
| CDK2 | phosphorylation → up-regulates activity | PLK1 | SIGNOR-280212 |
| MAP3K8 | phosphorylation → up-regulates | PLK1 | SIGNOR-92274 |
| AURKA | phosphorylation → up-regulates | PLK1 | SIGNOR-179422 |
| CHEK1 | phosphorylation → up-regulates activity | PLK1 | SIGNOR-279501 |
| AURKB | phosphorylation → up-regulates activity | PLK1 | SIGNOR-279358 |
