Entity Details

Name DAPK1
ID P53355
Role kinase
Enzymatic Domains
Protein kinase 13-275
PROSITE-ProRule
Roc 681-955
PROSITE-ProRule
Death 1312-1396
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
DAPK1DDX58Thr667ILTGRGKtNQNTGMTphosphorylation
down-regulates activity
28132841SIGNOR-277336
DAPK1DDX58Ser8MTTEQRRsLQAFQDYphosphorylation
down-regulates activity
30985869SIGNOR-279519
DAPK1TP53Ser20PLSQETFsDLWKLLPphosphorylation
up-regulates
17339337SIGNOR-153487
DAPK1TP53Thr18EPPLSQEtFSDLWKLphosphorylation
up-regulates
17339337SIGNOR-153491
DAPK1APPThr743VEVDAAVtPEERHLSphosphorylation
up-regulates quantity
27094130SIGNOR-279518
DAPK1TPM1Ser283HALNDMTsIphosphorylation
up-regulates activity
17895359SIGNOR-262845
DAPK1MYL12ASer19KRPQRATsNVFAMFDphosphorylation
up-regulates activity
11485996SIGNOR-262842
DAPK1MYL12AThr18KKRPQRAtSNVFAMFphosphorylation
up-regulates activity
11485996SIGNOR-262843
DAPK1MCM3Ser160KTIERRYsDLTTLVAphosphorylation
unknown
18283219SIGNOR-160958
DAPK1SNCASer129NEAYEMPsEEGYQDYphosphorylation
up-regulates quantity
32624505SIGNOR-278440
DAPK1RPL5–phosphorylation
unknown
18283219SIGNOR-160954
DAPK1DAPK1Ser308ARKKWKQsVRLISLCphosphorylation
down-regulates activity
11579085SIGNOR-110807
DAPK1PKD1–phosphorylation
up-regulates activity
28361035SIGNOR-279985
DAPK1GRIN2BSer1303NKLRRQHsYDTFVDLphosphorylation
up-regulates activity
20141836SIGNOR-278397
DAPK1PIN1Ser71HSQSRRPsSWRQEKIphosphorylation
down-regulates activity
21497122SIGNOR-278160
DAPK1BECN1Thr119LSRRLKVtGDLFDIMphosphorylation
up-regulates
19180116SIGNOR-183548
DAPK1BECN1Thr119LSRRLKVtGDLFDIMphosphorylation
up-regulates
19395874SIGNOR-185589
DAPK1STX1ASer188IIMDSSIsKQALSEIphosphorylation
down-regulates activity
12730201SIGNOR-251083
DAPK1PELI1Ser39GDRGRRKsRFALFKRphosphorylation
down-regulates quantity by destabilization
33052227SIGNOR-277531
DAPK1CAMKK2Ser511RREERSLsAPGNLLTphosphorylation
down-regulates
15209507SIGNOR-126241
DAPK1CAMKK2Ser511RREERSLsAPGNLLTphosphorylation
unknown
15209507SIGNOR-126245
DAPK1NDRG2–phosphorylation
up-regulates activity
32500074SIGNOR-279983
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
DAPK1phosphorylation
up-regulates
→
DDX58
PThr667
phosphorylation
down-regulates
⊣
DDX5828132841SIGNOR-277336
DAPK1phosphorylation
up-regulates
→
DDX58
PSer8
phosphorylation
down-regulates
⊣
DDX5830985869SIGNOR-279519
DAPK1phosphorylation
up-regulates
→
TP53
PSer20
phosphorylation
up-regulates
→
TP5317339337SIGNOR-153487
DAPK1phosphorylation
up-regulates
→
TP53
PThr18
phosphorylation
up-regulates
→
TP5317339337SIGNOR-153491
DAPK1phosphorylation
up-regulates
→
APP
PThr743
phosphorylation
up-regulates
→
APP27094130SIGNOR-279518
DAPK1phosphorylation
up-regulates
→
TPM1
PSer283
phosphorylation
up-regulates
→
TPM117895359SIGNOR-262845
DAPK1phosphorylation
up-regulates
→
MYL12A
PSer19
phosphorylation
up-regulates
→
MYL12A11485996SIGNOR-262842
DAPK1phosphorylation
up-regulates
→
MYL12A
PThr18
phosphorylation
up-regulates
→
MYL12A11485996SIGNOR-262843
DAPK1phosphorylation
up-regulates
→
MCM3
PSer160
phosphorylation
down-regulates
⊣
MCM318283219SIGNOR-160958
DAPK1phosphorylation
up-regulates
→
SNCA
PSer129
phosphorylation
up-regulates
→
SNCA32624505SIGNOR-278440
DAPK1phosphorylation
up-regulates
→
DAPK1
PSer308
phosphorylation
down-regulates
⊣
DAPK111579085SIGNOR-110807
DAPK1phosphorylation
up-regulates
→
GRIN2B
PSer1303
phosphorylation
up-regulates
→
GRIN2B20141836SIGNOR-278397
DAPK1phosphorylation
up-regulates
→
PIN1
PSer71
phosphorylation
down-regulates
⊣
PIN121497122SIGNOR-278160
DAPK1phosphorylation
up-regulates
→
BECN1
PThr119
phosphorylation
up-regulates
→
BECN119180116SIGNOR-183548
DAPK1phosphorylation
up-regulates
→
BECN1
PThr119
phosphorylation
up-regulates
→
BECN119395874SIGNOR-185589
DAPK1phosphorylation
up-regulates
→
STX1A
PSer188
phosphorylation
down-regulates
⊣
STX1A12730201SIGNOR-251083
DAPK1phosphorylation
up-regulates
→
PELI1
PSer39
phosphorylation
down-regulates
⊣
PELI133052227SIGNOR-277531
DAPK1phosphorylation
up-regulates
→
CAMKK2
PSer511
phosphorylation
down-regulates
⊣
CAMKK215209507SIGNOR-126241
DAPK1phosphorylation
up-regulates
→
CAMKK2
PSer511
phosphorylation
down-regulates
⊣
CAMKK215209507SIGNOR-126245
Regulator Mechanism/Effect Target SIGNOR-ID
DAPK1phosphorylation
→
down-regulates activity
DDX58SIGNOR-277336
DAPK1phosphorylation
→
down-regulates activity
DDX58SIGNOR-279519
DAPK1phosphorylation
→
up-regulates
TP53SIGNOR-153487
DAPK1phosphorylation
→
up-regulates
TP53SIGNOR-153491
DAPK1phosphorylation
→
up-regulates quantity
APPSIGNOR-279518
DAPK1phosphorylation
→
up-regulates activity
TPM1SIGNOR-262845
DAPK1phosphorylation
→
up-regulates activity
MYL12ASIGNOR-262842
DAPK1phosphorylation
→
up-regulates activity
MYL12ASIGNOR-262843
DAPK1phosphorylation
→
unknown
MCM3SIGNOR-160958
DAPK1phosphorylation
→
up-regulates quantity
SNCASIGNOR-278440
DAPK1phosphorylation
→
unknown
RPL5SIGNOR-160954
DAPK1phosphorylation
→
down-regulates activity
DAPK1SIGNOR-110807
DAPK1phosphorylation
→
up-regulates activity
PKD1SIGNOR-279985
DAPK1phosphorylation
→
up-regulates activity
GRIN2BSIGNOR-278397
DAPK1phosphorylation
→
down-regulates activity
PIN1SIGNOR-278160
DAPK1phosphorylation
→
up-regulates
BECN1SIGNOR-183548
DAPK1phosphorylation
→
up-regulates
BECN1SIGNOR-185589
DAPK1phosphorylation
→
down-regulates activity
STX1ASIGNOR-251083
DAPK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
PELI1SIGNOR-277531
DAPK1phosphorylation
img/direct_inhibition.png
down-regulates
CAMKK2SIGNOR-126241
DAPK1phosphorylation
→
unknown
CAMKK2SIGNOR-126245
DAPK1phosphorylation
→
up-regulates activity
NDRG2SIGNOR-279983