| Name | DAPK1 |
| ID | P53355 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 13-275 PROSITE-ProRule
Roc 681-955 PROSITE-ProRule
Death 1312-1396 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DAPK1 | DDX58 | Thr667 | ILTGRGKtNQNTGMT | phosphorylation down-regulates activity | 28132841 | SIGNOR-277336 |
| DAPK1 | DDX58 | Ser8 | MTTEQRRsLQAFQDY | phosphorylation down-regulates activity | 30985869 | SIGNOR-279519 |
| DAPK1 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 17339337 | SIGNOR-153487 |
| DAPK1 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates | 17339337 | SIGNOR-153491 |
| DAPK1 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation up-regulates quantity | 27094130 | SIGNOR-279518 |
| DAPK1 | TPM1 | Ser283 | HALNDMTsI | phosphorylation up-regulates activity | 17895359 | SIGNOR-262845 |
| DAPK1 | MYL12A | Ser19 | KRPQRATsNVFAMFD | phosphorylation up-regulates activity | 11485996 | SIGNOR-262842 |
| DAPK1 | MYL12A | Thr18 | KKRPQRAtSNVFAMF | phosphorylation up-regulates activity | 11485996 | SIGNOR-262843 |
| DAPK1 | MCM3 | Ser160 | KTIERRYsDLTTLVA | phosphorylation unknown | 18283219 | SIGNOR-160958 |
| DAPK1 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation up-regulates quantity | 32624505 | SIGNOR-278440 |
| DAPK1 | RPL5 | – | phosphorylation unknown | 18283219 | SIGNOR-160954 | |
| DAPK1 | DAPK1 | Ser308 | ARKKWKQsVRLISLC | phosphorylation down-regulates activity | 11579085 | SIGNOR-110807 |
| DAPK1 | PKD1 | – | phosphorylation up-regulates activity | 28361035 | SIGNOR-279985 | |
| DAPK1 | GRIN2B | Ser1303 | NKLRRQHsYDTFVDL | phosphorylation up-regulates activity | 20141836 | SIGNOR-278397 |
| DAPK1 | PIN1 | Ser71 | HSQSRRPsSWRQEKI | phosphorylation down-regulates activity | 21497122 | SIGNOR-278160 |
| DAPK1 | BECN1 | Thr119 | LSRRLKVtGDLFDIM | phosphorylation up-regulates | 19180116 | SIGNOR-183548 |
| DAPK1 | BECN1 | Thr119 | LSRRLKVtGDLFDIM | phosphorylation up-regulates | 19395874 | SIGNOR-185589 |
| DAPK1 | STX1A | Ser188 | IIMDSSIsKQALSEI | phosphorylation down-regulates activity | 12730201 | SIGNOR-251083 |
| DAPK1 | PELI1 | Ser39 | GDRGRRKsRFALFKR | phosphorylation down-regulates quantity by destabilization | 33052227 | SIGNOR-277531 |
| DAPK1 | CAMKK2 | Ser511 | RREERSLsAPGNLLT | phosphorylation down-regulates | 15209507 | SIGNOR-126241 |
| DAPK1 | CAMKK2 | Ser511 | RREERSLsAPGNLLT | phosphorylation unknown | 15209507 | SIGNOR-126245 |
| DAPK1 | NDRG2 | – | phosphorylation up-regulates activity | 32500074 | SIGNOR-279983 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DAPK1 | phosphorylation up-regulates → | DDX58 PThr667 | phosphorylation down-regulates ⊣ | DDX58 | 28132841 | SIGNOR-277336 |
| DAPK1 | phosphorylation up-regulates → | DDX58 PSer8 | phosphorylation down-regulates ⊣ | DDX58 | 30985869 | SIGNOR-279519 |
| DAPK1 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153487 |
| DAPK1 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153491 |
| DAPK1 | phosphorylation up-regulates → | APP PThr743 | phosphorylation up-regulates → | APP | 27094130 | SIGNOR-279518 |
| DAPK1 | phosphorylation up-regulates → | TPM1 PSer283 | phosphorylation up-regulates → | TPM1 | 17895359 | SIGNOR-262845 |
| DAPK1 | phosphorylation up-regulates → | MYL12A PSer19 | phosphorylation up-regulates → | MYL12A | 11485996 | SIGNOR-262842 |
| DAPK1 | phosphorylation up-regulates → | MYL12A PThr18 | phosphorylation up-regulates → | MYL12A | 11485996 | SIGNOR-262843 |
| DAPK1 | phosphorylation up-regulates → | MCM3 PSer160 | phosphorylation down-regulates ⊣ | MCM3 | 18283219 | SIGNOR-160958 |
| DAPK1 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation up-regulates → | SNCA | 32624505 | SIGNOR-278440 |
| DAPK1 | phosphorylation up-regulates → | DAPK1 PSer308 | phosphorylation down-regulates ⊣ | DAPK1 | 11579085 | SIGNOR-110807 |
| DAPK1 | phosphorylation up-regulates → | GRIN2B PSer1303 | phosphorylation up-regulates → | GRIN2B | 20141836 | SIGNOR-278397 |
| DAPK1 | phosphorylation up-regulates → | PIN1 PSer71 | phosphorylation down-regulates ⊣ | PIN1 | 21497122 | SIGNOR-278160 |
| DAPK1 | phosphorylation up-regulates → | BECN1 PThr119 | phosphorylation up-regulates → | BECN1 | 19180116 | SIGNOR-183548 |
| DAPK1 | phosphorylation up-regulates → | BECN1 PThr119 | phosphorylation up-regulates → | BECN1 | 19395874 | SIGNOR-185589 |
| DAPK1 | phosphorylation up-regulates → | STX1A PSer188 | phosphorylation down-regulates ⊣ | STX1A | 12730201 | SIGNOR-251083 |
| DAPK1 | phosphorylation up-regulates → | PELI1 PSer39 | phosphorylation down-regulates ⊣ | PELI1 | 33052227 | SIGNOR-277531 |
| DAPK1 | phosphorylation up-regulates → | CAMKK2 PSer511 | phosphorylation down-regulates ⊣ | CAMKK2 | 15209507 | SIGNOR-126241 |
| DAPK1 | phosphorylation up-regulates → | CAMKK2 PSer511 | phosphorylation down-regulates ⊣ | CAMKK2 | 15209507 | SIGNOR-126245 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DAPK1 | phosphorylation → down-regulates activity | DDX58 | SIGNOR-277336 |
| DAPK1 | phosphorylation → down-regulates activity | DDX58 | SIGNOR-279519 |
| DAPK1 | phosphorylation → up-regulates | TP53 | SIGNOR-153487 |
| DAPK1 | phosphorylation → up-regulates | TP53 | SIGNOR-153491 |
| DAPK1 | phosphorylation → up-regulates quantity | APP | SIGNOR-279518 |
| DAPK1 | phosphorylation → up-regulates activity | TPM1 | SIGNOR-262845 |
| DAPK1 | phosphorylation → up-regulates activity | MYL12A | SIGNOR-262842 |
| DAPK1 | phosphorylation → up-regulates activity | MYL12A | SIGNOR-262843 |
| DAPK1 | phosphorylation → unknown | MCM3 | SIGNOR-160958 |
| DAPK1 | phosphorylation → up-regulates quantity | SNCA | SIGNOR-278440 |
| DAPK1 | phosphorylation → unknown | RPL5 | SIGNOR-160954 |
| DAPK1 | phosphorylation → down-regulates activity | DAPK1 | SIGNOR-110807 |
| DAPK1 | phosphorylation → up-regulates activity | PKD1 | SIGNOR-279985 |
| DAPK1 | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-278397 |
| DAPK1 | phosphorylation → down-regulates activity | PIN1 | SIGNOR-278160 |
| DAPK1 | phosphorylation → up-regulates | BECN1 | SIGNOR-183548 |
| DAPK1 | phosphorylation → up-regulates | BECN1 | SIGNOR-185589 |
| DAPK1 | phosphorylation → down-regulates activity | STX1A | SIGNOR-251083 |
| DAPK1 | phosphorylation![]() down-regulates quantity by destabilization | PELI1 | SIGNOR-277531 |
| DAPK1 | phosphorylation![]() down-regulates | CAMKK2 | SIGNOR-126241 |
| DAPK1 | phosphorylation → unknown | CAMKK2 | SIGNOR-126245 |
| DAPK1 | phosphorylation → up-regulates activity | NDRG2 | SIGNOR-279983 |