Summary

Name DAPK1
Full Name Death-associated protein kinase 1
Synonyms DAP kinase 1 | DAPK
Primary ID P53355
Links - -
Type protein
Relations 29
Pathways Neurotransmitters release
Function Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.; FUNCTION

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png phosphorylation SNCA 0.27
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.499
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MCM3 0.331
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation STX1A 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ up-regulates activity img/direct-activation.png phosphorylation MYL12A 0.275
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.56
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TPM1 0.277
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DAPK1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PELI1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CAMKK2 0.283
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ img/unknown.png phosphorylation CAMKK2 0.283
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png phosphorylation PIN1 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DAPK1 0.564
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BECN1 0.726
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DDX58 0.331
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation DAPK1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DAPK1 0.273
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation DAPK1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP1B 0.262
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK1 0.564
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPL5 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination DAPK1 0.438
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding DAPK1 0.397
Publications: 1 Organism: Homo Sapiens