| Name | DAPK1 |
| ID | P53355 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 13-275 PROSITE-ProRule
Roc 681-955 PROSITE-ProRule
Death 1312-1396 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRF | DAPK1 | Tyr491 | CAAWHGYySVAKALC | dephosphorylation up-regulates activity | 17803936 | SIGNOR-276075 |
| PTPRF | DAPK1 | Tyr490 | HCAAWHGyYSVAKAL | dephosphorylation up-regulates activity | 17803936 | SIGNOR-276076 |
| PTPRF | DAPK1 | Tyr491 | CAAWHGYySVAKALC | dephosphorylation up-regulates | 17803936 | SIGNOR-157706 |
| SRC | DAPK1 | Tyr491 | CAAWHGYySVAKALC | phosphorylation down-regulates activity | 17803936 | SIGNOR-276073 |
| SRC | DAPK1 | Tyr490 | HCAAWHGyYSVAKAL | phosphorylation down-regulates activity | 17803936 | SIGNOR-276074 |
| MAPK1 | DAPK1 | Ser734 | NSSRFPPsPLASKPT | phosphorylation up-regulates | 15616583 | SIGNOR-132614 |
| PTPRF | DAPK1 | Tyr490 | HCAAWHGyYSVAKAL | dephosphorylation up-regulates | 17803936 | SIGNOR-157702 |
| DAPK1 | DAPK1 | Ser308 | ARKKWKQsVRLISLC | phosphorylation down-regulates activity | 11579085 | SIGNOR-110807 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRF | dephosphorylation down-regulates ⊣ | DAPK1 PTyr491 | dephosphorylation down-regulates ⊣ | DAPK1 | 17803936 | SIGNOR-276075 |
| PTPRF | dephosphorylation down-regulates ⊣ | DAPK1 PTyr490 | dephosphorylation down-regulates ⊣ | DAPK1 | 17803936 | SIGNOR-276076 |
| PTPRF | dephosphorylation down-regulates ⊣ | DAPK1 PTyr491 | dephosphorylation down-regulates ⊣ | DAPK1 | 17803936 | SIGNOR-157706 |
| SRC | phosphorylation up-regulates → | DAPK1 PTyr491 | phosphorylation down-regulates ⊣ | DAPK1 | 17803936 | SIGNOR-276073 |
| SRC | phosphorylation up-regulates → | DAPK1 PTyr490 | phosphorylation down-regulates ⊣ | DAPK1 | 17803936 | SIGNOR-276074 |
| MAPK1 | phosphorylation up-regulates → | DAPK1 PSer734 | phosphorylation up-regulates → | DAPK1 | 15616583 | SIGNOR-132614 |
| PTPRF | dephosphorylation down-regulates ⊣ | DAPK1 PTyr490 | dephosphorylation down-regulates ⊣ | DAPK1 | 17803936 | SIGNOR-157702 |
| DAPK1 | phosphorylation up-regulates → | DAPK1 PSer308 | phosphorylation down-regulates ⊣ | DAPK1 | 11579085 | SIGNOR-110807 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRF | dephosphorylation → up-regulates activity | DAPK1 | SIGNOR-276075 |
| PTPRF | dephosphorylation → up-regulates activity | DAPK1 | SIGNOR-276076 |
| PTPRF | dephosphorylation → up-regulates | DAPK1 | SIGNOR-157706 |
| SRC | phosphorylation → down-regulates activity | DAPK1 | SIGNOR-276073 |
| SRC | phosphorylation → down-regulates activity | DAPK1 | SIGNOR-276074 |
| MAPK1 | phosphorylation → up-regulates | DAPK1 | SIGNOR-132614 |
| PTPRF | dephosphorylation → up-regulates | DAPK1 | SIGNOR-157702 |
| DAPK1 | phosphorylation → down-regulates activity | DAPK1 | SIGNOR-110807 |