| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | DAPK1 | Tyr491 | CAAWHGYySVAKALC | phosphorylation down-regulates activity | 17803936 | SIGNOR-276073 |
| PTPRF | DAPK1 | Tyr491 | CAAWHGYySVAKALC | dephosphorylation up-regulates | 17803936 | SIGNOR-157706 |
| PTPRF | DAPK1 | Tyr491 | CAAWHGYySVAKALC | dephosphorylation up-regulates activity | 17803936 | SIGNOR-276075 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | DAPK1 PTyr491 | phosphorylation down-regulates ⊣ | DAPK1 | 17803936 | SIGNOR-276073 |
| PTPRF | dephosphorylation down-regulates ⊣ | DAPK1 PTyr491 | dephosphorylation down-regulates ⊣ | DAPK1 | 17803936 | SIGNOR-157706 |
| PTPRF | dephosphorylation down-regulates ⊣ | DAPK1 PTyr491 | dephosphorylation down-regulates ⊣ | DAPK1 | 17803936 | SIGNOR-276075 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → down-regulates activity | DAPK1 | SIGNOR-276073 |
| PTPRF | dephosphorylation → up-regulates | DAPK1 | SIGNOR-157706 |
| PTPRF | dephosphorylation → up-regulates activity | DAPK1 | SIGNOR-276075 |
