Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAPK12	EEF2K	Ser396	TFDSLPSsPSSATPH	phosphorylation unknown	12171600	SIGNOR-250137
MAPK12	SH3BP5	Ser351	PGSLDLPsPVSLSEF	phosphorylation unknown	15158451	SIGNOR-250140
MAPK12	SH3BP5	Ser421	SKSQSSTsPEGQALE	phosphorylation unknown	15158451	SIGNOR-250141
MAPK12	TP53	Ser33	LPENNVLsPLPSQAM	phosphorylation up-regulates activity	19251701	SIGNOR-280026
MAPK12	KRT8	Ser74	TVNQSLLsPLVLEVD	phosphorylation up-regulates	11788583	SIGNOR-114067
MAPK12	MAPT	Ser519	SGYSSPGsPGTPGSR	phosphorylation down-regulates activity	9199504	SIGNOR-250084
MAPK12	MAPT	Ser637	VDLSKVTsKCGSLGN	phosphorylation down-regulates activity	9199504	SIGNOR-250085
MAPK12	MAPT	Thr498	KTPPAPKtPPSSGEP	phosphorylation down-regulates activity	9199504	SIGNOR-250086
MAPK12	MAPT	Thr522	SSPGSPGtPGSRSRT	phosphorylation down-regulates activity	9199504	SIGNOR-250087
MAPK12	MAPT	Thr548	KKVAVVRtPPKSPSS	phosphorylation down-regulates activity	9199504	SIGNOR-250088
MAPK12	MYOD1	Ser200	YSGDSDAsSPRSNCS	phosphorylation up-regulates activity	20026657	SIGNOR-276274
MAPK12	MYOD1	Ser201	SGDSDASsPRSNCSD	phosphorylation up-regulates activity	20026657	SIGNOR-276273
MAPK12	ATF2	–		phosphorylation up-regulates	10085140	SIGNOR-65589
MAPK12	NUP62	Ser272	SGTSTTTsTAATATA	phosphorylation down-regulates quantity by destabilization	30401435	SIGNOR-277416
MAPK12	NUP62	Thr269	GAASGTStTTSTAAT	phosphorylation down-regulates quantity by destabilization	30401435	SIGNOR-277415
MAPK12	TP53BP1	Thr1609	LGPYEAVtPLTKAAD	phosphorylation down-regulates activity	24703952	SIGNOR-264448
MAPK12	SNTA1	Ser193	GWDSPPAsPLQRQPS	phosphorylation up-regulates	10212242	SIGNOR-67061
MAPK12	SNTA1	Ser201	PLQRQPSsPGPTPRN	phosphorylation up-regulates	10212242	SIGNOR-67065
MAPK12	PFKFB3	Ser467	NSVTPLAsPEPTKKP	phosphorylation up-regulates quantity	32580961	SIGNOR-279539
MAPK12	RCSD1	Ser108	LPGASPKsPGLKAMV	phosphorylation down-regulates activity	15850461	SIGNOR-263083
MAPK12	CARM1	Ser595	GPAISMAsPMSIPTN	phosphorylation down-regulates activity	29681515	SIGNOR-255897

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAPK12	phosphorylation up-regulates →	EEF2K PSer396	phosphorylation down-regulates ⊣	EEF2K	12171600	SIGNOR-250137
MAPK12	phosphorylation up-regulates →	SH3BP5 PSer351	phosphorylation down-regulates ⊣	SH3BP5	15158451	SIGNOR-250140
MAPK12	phosphorylation up-regulates →	SH3BP5 PSer421	phosphorylation down-regulates ⊣	SH3BP5	15158451	SIGNOR-250141
MAPK12	phosphorylation up-regulates →	TP53 PSer33	phosphorylation up-regulates →	TP53	19251701	SIGNOR-280026
MAPK12	phosphorylation up-regulates →	KRT8 PSer74	phosphorylation up-regulates →	KRT8	11788583	SIGNOR-114067
MAPK12	phosphorylation up-regulates →	MAPT PSer519	phosphorylation down-regulates ⊣	MAPT	9199504	SIGNOR-250084
MAPK12	phosphorylation up-regulates →	MAPT PSer637	phosphorylation down-regulates ⊣	MAPT	9199504	SIGNOR-250085
MAPK12	phosphorylation up-regulates →	MAPT PThr498	phosphorylation down-regulates ⊣	MAPT	9199504	SIGNOR-250086
MAPK12	phosphorylation up-regulates →	MAPT PThr522	phosphorylation down-regulates ⊣	MAPT	9199504	SIGNOR-250087
MAPK12	phosphorylation up-regulates →	MAPT PThr548	phosphorylation down-regulates ⊣	MAPT	9199504	SIGNOR-250088
MAPK12	phosphorylation up-regulates →	MYOD1 PSer200	phosphorylation up-regulates →	MYOD1	20026657	SIGNOR-276274
MAPK12	phosphorylation up-regulates →	MYOD1 PSer201	phosphorylation up-regulates →	MYOD1	20026657	SIGNOR-276273
MAPK12	phosphorylation up-regulates →	NUP62 PSer272	phosphorylation down-regulates ⊣	NUP62	30401435	SIGNOR-277416
MAPK12	phosphorylation up-regulates →	NUP62 PThr269	phosphorylation down-regulates ⊣	NUP62	30401435	SIGNOR-277415
MAPK12	phosphorylation up-regulates →	TP53BP1 PThr1609	phosphorylation down-regulates ⊣	TP53BP1	24703952	SIGNOR-264448
MAPK12	phosphorylation up-regulates →	SNTA1 PSer193	phosphorylation up-regulates →	SNTA1	10212242	SIGNOR-67061
MAPK12	phosphorylation up-regulates →	SNTA1 PSer201	phosphorylation up-regulates →	SNTA1	10212242	SIGNOR-67065
MAPK12	phosphorylation up-regulates →	PFKFB3 PSer467	phosphorylation up-regulates →	PFKFB3	32580961	SIGNOR-279539
MAPK12	phosphorylation up-regulates →	RCSD1 PSer108	phosphorylation down-regulates ⊣	RCSD1	15850461	SIGNOR-263083
MAPK12	phosphorylation up-regulates →	CARM1 PSer595	phosphorylation down-regulates ⊣	CARM1	29681515	SIGNOR-255897

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAPK12	phosphorylation → unknown	EEF2K	SIGNOR-250137
MAPK12	phosphorylation → unknown	SH3BP5	SIGNOR-250140
MAPK12	phosphorylation → unknown	SH3BP5	SIGNOR-250141
MAPK12	phosphorylation → up-regulates activity	TP53	SIGNOR-280026
MAPK12	phosphorylation → up-regulates	KRT8	SIGNOR-114067
MAPK12	phosphorylation → down-regulates activity	MAPT	SIGNOR-250084
MAPK12	phosphorylation → down-regulates activity	MAPT	SIGNOR-250085
MAPK12	phosphorylation → down-regulates activity	MAPT	SIGNOR-250086
MAPK12	phosphorylation → down-regulates activity	MAPT	SIGNOR-250087
MAPK12	phosphorylation → down-regulates activity	MAPT	SIGNOR-250088
MAPK12	phosphorylation → up-regulates activity	MYOD1	SIGNOR-276274
MAPK12	phosphorylation → up-regulates activity	MYOD1	SIGNOR-276273
MAPK12	phosphorylation → up-regulates	ATF2	SIGNOR-65589
MAPK12	phosphorylation down-regulates quantity by destabilization	NUP62	SIGNOR-277416
MAPK12	phosphorylation down-regulates quantity by destabilization	NUP62	SIGNOR-277415
MAPK12	phosphorylation → down-regulates activity	TP53BP1	SIGNOR-264448
MAPK12	phosphorylation → up-regulates	SNTA1	SIGNOR-67061
MAPK12	phosphorylation → up-regulates	SNTA1	SIGNOR-67065
MAPK12	phosphorylation → up-regulates quantity	PFKFB3	SIGNOR-279539
MAPK12	phosphorylation → down-regulates activity	RCSD1	SIGNOR-263083
MAPK12	phosphorylation → down-regulates activity	CARM1	SIGNOR-255897