Summary

Name MAPK12
Full Name Mitogen-activated protein kinase 12
Synonyms MAP kinase 12, MAPK 12, Extracellular signal-regulated kinase 6, ERK-6, Mitogen-activated protein kinase p38 gamma, MAP kinase p38 gamma, Stress-activated protein kinase 3 | ERK6, SAPK3
Primary ID P53778
Links - -
Type protein
Relations 26
Pathways Satellite: Dystrophin glycoprotein complex regulation
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation RCSD1 0.524
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation SNTA1 0.653
Publications: 2 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ img/unknown.png phosphorylation SH3BP5 0.456
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation EEF2K 0.334
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation MAPT 0.499
Publications: 5 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation CARM1 0.343
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation KRT8 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TP53BP1 0.2
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK12 0.302
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK12 0.639
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding, MAPK12 0.376
Publications: 2 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png phosphorylation MAPK12 0.628
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding MAPK12/CARM1 0.343
Publications: 1
+ up-regulates img/indirect-activation.png MAPK12 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK12 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.517
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Satellite_cells_self-renewal 0.7
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation JUNB 0.367
Publications: 1 Organism: Homo Sapiens