| Name | MAPK12 |
| ID | P53778 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 27-311 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K6 | MAPK12 | Thr183 | RQADSEMtGYVVTRW | phosphorylation up-regulates | 19230643 | SIGNOR-184134 |
| MAP2K3 | MAPK12 | – | phosphorylation up-regulates | 11062067 | SIGNOR-83718 | |
| MAP2K6 | MAPK12 | Tyr185 | ADSEMTGyVVTRWYR | phosphorylation up-regulates | 19230643 | SIGNOR-184138 |
| PPM1D | MAPK12 | Thr183 | RQADSEMtGYVVTRW | dephosphorylation down-regulates | 15870257 | SIGNOR-135976 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K6 | phosphorylation up-regulates → | MAPK12 PThr183 | phosphorylation up-regulates → | MAPK12 | 19230643 | SIGNOR-184134 |
| MAP2K6 | phosphorylation up-regulates → | MAPK12 PTyr185 | phosphorylation up-regulates → | MAPK12 | 19230643 | SIGNOR-184138 |
| PPM1D | dephosphorylation down-regulates ⊣ | MAPK12 PThr183 | dephosphorylation up-regulates → | MAPK12 | 15870257 | SIGNOR-135976 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP2K6 | phosphorylation → up-regulates | MAPK12 | SIGNOR-184134 |
| MAP2K3 | phosphorylation → up-regulates | MAPK12 | SIGNOR-83718 |
| MAP2K6 | phosphorylation → up-regulates | MAPK12 | SIGNOR-184138 |
| PPM1D | dephosphorylation down-regulates | MAPK12 | SIGNOR-135976 |