| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K6 | MAPK12 | Thr183 | RQADSEMtGYVVTRW | phosphorylation up-regulates | 19230643 | SIGNOR-184134 |
| PPM1D | MAPK12 | Thr183 | RQADSEMtGYVVTRW | dephosphorylation down-regulates | 15870257 | SIGNOR-135976 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K6 | phosphorylation up-regulates → | MAPK12 PThr183 | phosphorylation up-regulates → | MAPK12 | 19230643 | SIGNOR-184134 |
| PPM1D | dephosphorylation down-regulates ⊣ | MAPK12 PThr183 | dephosphorylation up-regulates → | MAPK12 | 15870257 | SIGNOR-135976 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP2K6 | phosphorylation → up-regulates | MAPK12 | SIGNOR-184134 |
| PPM1D | dephosphorylation down-regulates | MAPK12 | SIGNOR-135976 |
