| Name | MAPK10 |
| ID | P53779 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 64-359 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK10 | BCL2L11 | Ser69 | GPLAPPAsPGPFATR | phosphorylation down-regulates quantity by destabilization | 15486195 | SIGNOR-250080 |
| MAPK10 | BCL2L11 | Thr116 | SCDKSTQtPSPPCQA | phosphorylation up-regulates | 18498746 | SIGNOR-178683 |
| MAPK10 | BCL2L11 | Ser59 | GDSCPHGsPQGPLAP | phosphorylation up-regulates activity | 12818176 | SIGNOR-250130 |
| MAPK10 | BCL2L11 | Ser77 | PGPFATRsPLFIFMR | phosphorylation up-regulates activity | 12818176 | SIGNOR-250131 |
| MAPK10 | KIF5C | Ser176 | CTERFVSsPEEVMDV | phosphorylation down-regulates activity | 19525941 | SIGNOR-262950 |
| MAPK10 | NFATC1 | Ser172 | YRDPSCLsPASSLSS | phosphorylation down-regulates | 10652349 | SIGNOR-74556 |
| MAPK10 | TP53 | – | phosphorylation up-regulates | 14699954 | SIGNOR-120552 | |
| MAPK10 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation up-regulates | 24610780 | SIGNOR-204671 |
| MAPK10 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 20395206 | SIGNOR-164800 |
| MAPK10 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 20395206 | SIGNOR-164804 |
| MAPK10 | STMN1 | Ser38 | SVPEFPLsPPKKKDL | phosphorylation down-regulates | 20630875 | SIGNOR-166690 |
| MAPK10 | CDC25C | Ser168 | SEMKYLGsPITTVPK | phosphorylation down-regulates | 20220133 | SIGNOR-164085 |
| MAPK10 | SFN | Ser186 | FHYEIANsPEEAISL | phosphorylation down-regulates | 15071501 | SIGNOR-124005 |
| MAPK10 | ATN1 | Ser739 | EEYETPEsPVPPARS | phosphorylation down-regulates activity | 12812981 | SIGNOR-102394 |
| MAPK10 | HNRNPK | Ser284 | RRDYDDMsPRRGPPP | phosphorylation down-regulates activity | 11231586 | SIGNOR-250082 |
| MAPK10 | HNRNPK | Ser216 | ILDLISEsPIKGRAQ | phosphorylation up-regulates activity | 11259409 | SIGNOR-250081 |
| MAPK10 | HNRNPK | Ser353 | DSAIDTWsPSEWQMA | phosphorylation up-regulates activity | 11259409 | SIGNOR-250083 |
| MAPK10 | YWHAZ | Ser184 | FYYEILNsPEKACSL | phosphorylation down-regulates | 15071501 | SIGNOR-124009 |
| MAPK10 | PPM1J | Ser93 | HAGRAVQsPPDTGRR | phosphorylation down-regulates | 18553930 | SIGNOR-178926 |
| MAPK10 | STMN2 | Ser62 | ELILKPPsPISEAPR | phosphorylation down-regulates | 11718727 | SIGNOR-112110 |
| MAPK10 | STMN2 | Ser73 | EAPRTLAsPKKKDLS | phosphorylation down-regulates | 11718727 | SIGNOR-112114 |
| MAPK10 | DIABLO | – | phosphorylation down-regulates | 17686459 | SIGNOR-157280 | |
| MAPK10 | MAPK8IP3 | Thr265 | GQSSAAAtPSTTGTK | phosphorylation up-regulates | 15767678 | SIGNOR-134529 |
| MAPK10 | MAPK8IP3 | Thr275 | TTGTKSNtPTSSVPS | phosphorylation up-regulates | 15767678 | SIGNOR-134533 |
| MAPK10 | MAPK8IP3 | Thr286 | SVPSAAVtPLNESLQ | phosphorylation up-regulates | 15767678 | SIGNOR-134537 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK10 | phosphorylation up-regulates → | BCL2L11 PSer69 | phosphorylation down-regulates ⊣ | BCL2L11 | 15486195 | SIGNOR-250080 |
| MAPK10 | phosphorylation up-regulates → | BCL2L11 PThr116 | phosphorylation up-regulates → | BCL2L11 | 18498746 | SIGNOR-178683 |
| MAPK10 | phosphorylation up-regulates → | BCL2L11 PSer59 | phosphorylation up-regulates → | BCL2L11 | 12818176 | SIGNOR-250130 |
| MAPK10 | phosphorylation up-regulates → | BCL2L11 PSer77 | phosphorylation up-regulates → | BCL2L11 | 12818176 | SIGNOR-250131 |
| MAPK10 | phosphorylation up-regulates → | KIF5C PSer176 | phosphorylation down-regulates ⊣ | KIF5C | 19525941 | SIGNOR-262950 |
| MAPK10 | phosphorylation up-regulates → | NFATC1 PSer172 | phosphorylation down-regulates ⊣ | NFATC1 | 10652349 | SIGNOR-74556 |
| MAPK10 | phosphorylation up-regulates → | APP PThr743 | phosphorylation up-regulates → | APP | 24610780 | SIGNOR-204671 |
| MAPK10 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 20395206 | SIGNOR-164800 |
| MAPK10 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 20395206 | SIGNOR-164804 |
| MAPK10 | phosphorylation up-regulates → | STMN1 PSer38 | phosphorylation down-regulates ⊣ | STMN1 | 20630875 | SIGNOR-166690 |
| MAPK10 | phosphorylation up-regulates → | CDC25C PSer168 | phosphorylation down-regulates ⊣ | CDC25C | 20220133 | SIGNOR-164085 |
| MAPK10 | phosphorylation up-regulates → | SFN PSer186 | phosphorylation down-regulates ⊣ | SFN | 15071501 | SIGNOR-124005 |
| MAPK10 | phosphorylation up-regulates → | ATN1 PSer739 | phosphorylation down-regulates ⊣ | ATN1 | 12812981 | SIGNOR-102394 |
| MAPK10 | phosphorylation up-regulates → | HNRNPK PSer284 | phosphorylation down-regulates ⊣ | HNRNPK | 11231586 | SIGNOR-250082 |
| MAPK10 | phosphorylation up-regulates → | HNRNPK PSer216 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-250081 |
| MAPK10 | phosphorylation up-regulates → | HNRNPK PSer353 | phosphorylation up-regulates → | HNRNPK | 11259409 | SIGNOR-250083 |
| MAPK10 | phosphorylation up-regulates → | YWHAZ PSer184 | phosphorylation down-regulates ⊣ | YWHAZ | 15071501 | SIGNOR-124009 |
| MAPK10 | phosphorylation up-regulates → | PPM1J PSer93 | phosphorylation down-regulates ⊣ | PPM1J | 18553930 | SIGNOR-178926 |
| MAPK10 | phosphorylation up-regulates → | STMN2 PSer62 | phosphorylation down-regulates ⊣ | STMN2 | 11718727 | SIGNOR-112110 |
| MAPK10 | phosphorylation up-regulates → | STMN2 PSer73 | phosphorylation down-regulates ⊣ | STMN2 | 11718727 | SIGNOR-112114 |
| MAPK10 | phosphorylation up-regulates → | MAPK8IP3 PThr265 | phosphorylation up-regulates → | MAPK8IP3 | 15767678 | SIGNOR-134529 |
| MAPK10 | phosphorylation up-regulates → | MAPK8IP3 PThr275 | phosphorylation up-regulates → | MAPK8IP3 | 15767678 | SIGNOR-134533 |
| MAPK10 | phosphorylation up-regulates → | MAPK8IP3 PThr286 | phosphorylation up-regulates → | MAPK8IP3 | 15767678 | SIGNOR-134537 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK10 | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-250080 |
| MAPK10 | phosphorylation → up-regulates | BCL2L11 | SIGNOR-178683 |
| MAPK10 | phosphorylation → up-regulates activity | BCL2L11 | SIGNOR-250130 |
| MAPK10 | phosphorylation → up-regulates activity | BCL2L11 | SIGNOR-250131 |
| MAPK10 | phosphorylation → down-regulates activity | KIF5C | SIGNOR-262950 |
| MAPK10 | phosphorylation down-regulates | NFATC1 | SIGNOR-74556 |
| MAPK10 | phosphorylation → up-regulates | TP53 | SIGNOR-120552 |
| MAPK10 | phosphorylation → up-regulates | APP | SIGNOR-204671 |
| MAPK10 | phosphorylation → up-regulates | JUN | SIGNOR-164800 |
| MAPK10 | phosphorylation → up-regulates | JUN | SIGNOR-164804 |
| MAPK10 | phosphorylation down-regulates | STMN1 | SIGNOR-166690 |
| MAPK10 | phosphorylation down-regulates | CDC25C | SIGNOR-164085 |
| MAPK10 | phosphorylation down-regulates | SFN | SIGNOR-124005 |
| MAPK10 | phosphorylation → down-regulates activity | ATN1 | SIGNOR-102394 |
| MAPK10 | phosphorylation → down-regulates activity | HNRNPK | SIGNOR-250082 |
| MAPK10 | phosphorylation → up-regulates activity | HNRNPK | SIGNOR-250081 |
| MAPK10 | phosphorylation → up-regulates activity | HNRNPK | SIGNOR-250083 |
| MAPK10 | phosphorylation down-regulates | YWHAZ | SIGNOR-124009 |
| MAPK10 | phosphorylation down-regulates | PPM1J | SIGNOR-178926 |
| MAPK10 | phosphorylation down-regulates | STMN2 | SIGNOR-112110 |
| MAPK10 | phosphorylation down-regulates | STMN2 | SIGNOR-112114 |
| MAPK10 | phosphorylation down-regulates | DIABLO | SIGNOR-157280 |
| MAPK10 | phosphorylation → up-regulates | MAPK8IP3 | SIGNOR-134529 |
| MAPK10 | phosphorylation → up-regulates | MAPK8IP3 | SIGNOR-134533 |
| MAPK10 | phosphorylation → up-regulates | MAPK8IP3 | SIGNOR-134537 |