Summary

Name MAPK10
Full Name Mitogen-activated protein kinase 10
Synonyms MAP kinase 10, MAPK 10, MAP kinase p49 3F12, Stress-activated protein kinase 1b, SAPK1b, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3 | JNK3, JNK3A, PRKM10, SAPK1B
Primary ID P53779
Links - -
Type protein
Relations 46
Inhibitors anthra[1,9-cd]pyrazol-6(2H)-one; 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[(5-nitro-2-thiazolyl)thio]-1H-1,2,4-triazol-5-one; profenamine
Function Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation CDC25C 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NFATC1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation YWHAZ 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SFN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HNRNPK 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HNRNPK 0.14
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation STMN1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCL2L11 0.2
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation STMN2 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation JUN 0.4
Publications: 2 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BCL2L11 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation ATN1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation PPM1J 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BCL2L11 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAPK10 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK10 0.46
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MAPK10 0.46
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK8IP3 0.22
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation APP 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK10 0.5
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MAPK10 0.5
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK10 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK10 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK10 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png MAPK10 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK10 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK10 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK10 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png BAX 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK10 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DIABLO 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK10 0.14
Publications: 1 Organism: Homo Sapiens