| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | HIRA | Thr555 | LSPSVLTtPSKIEPM | phosphorylation up-regulates activity | 11238922 | SIGNOR-105548 |
| CyclinE/CDK2 | HIRA | Thr555 | LSPSVLTtPSKIEPM | phosphorylation up-regulates | 11238922 | SIGNOR-216670 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | HIRA PThr555 | phosphorylation up-regulates → | HIRA | 11238922 | SIGNOR-105548 |
| CyclinE/CDK2 | phosphorylation up-regulates → | HIRA PThr555 | phosphorylation up-regulates → | HIRA | 11238922 | SIGNOR-216670 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation → up-regulates activity | HIRA | SIGNOR-105548 |
| CyclinE/CDK2 | phosphorylation → up-regulates | HIRA | SIGNOR-216670 |
