3.0
Summary
| Name |  HIRAView Modifications |
| Full Name | Protein HIRA |
| Synonyms | TUP1-like enhancer of split protein 1 | DGCR1, HIR, TUPLE1 |
| Primary ID | P54198 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CyclinE/CDK2 | up-regulates 
phosphorylation
|
HIRA | 0.327 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK2 | up-regulates activity
phosphorylation
|
HIRA | 0.327 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | U2-OS Cell | |||
| + | HIRA | form complex 
binding
|
HIRA complex 2 | 0.523 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HIRA | form complex
binding
|
HIRA complex 1 | 0.698 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | up-regulates activity
phosphorylation
|
HIRA | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |