Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PRKAA2	EEF2K	Ser366	SPQVRTLsGSRPPLL	phosphorylation down-regulates activity	14709557	SIGNOR-250319
PRKAA2	EEF2K	Ser78	SSGSPANsFHFKEAW	phosphorylation down-regulates activity	14709557	SIGNOR-250321
PRKAA2	EEF2K	Ser398	DSLPSSPsSATPHSQ	phosphorylation up-regulates activity	14709557	SIGNOR-250158
PRKAA2	ACACB	Ser222	PTMRPSMsGLHLVKR	phosphorylation down-regulates activity	14613924	SIGNOR-250316
PRKAA2	ACACB	Ser222	PTMRPSMsGLHLVKR	phosphorylation down-regulates activity	9148944	SIGNOR-250318
PRKAA2	IKBKB	Ser177	AKELDQGsLCTSFVG	phosphorylation up-regulates	21673972	SIGNOR-174401
PRKAA2	IKBKB	Ser181	DQGSLCTsFVGTLQY	phosphorylation up-regulates	21673972	SIGNOR-174405
PRKAA2	PFKFB2	Ser466	PVRMRRNsFTPLSSS	phosphorylation up-regulates activity	11069105	SIGNOR-250323
PRKAA2	ULK1	Ser317	SHLASPPsLGEMQQL	phosphorylation up-regulates	19584320	SIGNOR-186633
PRKAA2	ULK1	Ser556	GLGCRLHsAPNLSDL	phosphorylation up-regulates	19584320	SIGNOR-186637
PRKAA2	ULK1	Ser638	FDFPKTPsSQNLLAL	phosphorylation up-regulates	19584320	SIGNOR-186641
PRKAA2	ULK1	Ser317	SHLASPPsLGEMQQL	phosphorylation up-regulates	21205641	SIGNOR-170859
PRKAA2	ULK1	Ser556	GLGCRLHsAPNLSDL	phosphorylation up-regulates	21205641	SIGNOR-170863
PRKAA2	ULK1	Ser638	FDFPKTPsSQNLLAL	phosphorylation up-regulates	21205641	SIGNOR-170867
PRKAA2	TFAP2A	Ser219	CSVPGRLsLLSSTSK	phosphorylation up-regulates activity	22561688	SIGNOR-279648
PRKAA2	INSR	–		phosphorylation up-regulates	22207502	SIGNOR-195324
PRKAA2	PDHA1	Ser295	RYHGHSMsDPGVSYR	phosphorylation up-regulates activity	33022274	SIGNOR-276840
PRKAA2	PDHA1	Ser314	IQEVRSKsDPIMLLK	phosphorylation up-regulates activity	33022274	SIGNOR-276838
PRKAA2	DUSP1	Ser334	AVLDRGTsTTTVFNF	phosphorylation down-regulates quantity by destabilization	25799226	SIGNOR-276890
PRKAA2	CDC27	Ser379	NALPRRSsRLFTSDS	phosphorylation unknown	22137581	SIGNOR-195106
PRKAA2	SREBF1	Ser396	TAVHKSKsLKDLVSA	phosphorylation down-regulates	21459323	SIGNOR-173031
PRKAA2	HNF4A	Ser313	GKIKRLRsQVQVSLE	phosphorylation down-regulates quantity by destabilization	12740371	SIGNOR-250322
PRKAA2	TSC2	Ser1387	QPLSKSSsSPELQTL	phosphorylation up-regulates	16959574	SIGNOR-149388
PRKAA2	VASP	Thr278	LARRRKAtQVGEKTP	phosphorylation down-regulates	17082196	SIGNOR-150462
PRKAA2	VASP	Ser322	TTLPRMKsSSSVTTS	phosphorylation down-regulates	21945940	SIGNOR-176642
PRKAA2	ACACA	Ser80	LHIRSSMsGLHLVKQ	phosphorylation down-regulates	12015362	SIGNOR-87583
PRKAA2	PAK2	Ser20	APPVRMSsTIFSTGG	phosphorylation unknown	22137581	SIGNOR-195110
PRKAA2	PLD1	Ser505	GSVKRVTsGPSLGSL	phosphorylation up-regulates	20231899	SIGNOR-164293
PRKAA2	CRTC2	Ser171	SALNRTSsDSALHTS	phosphorylation down-regulates	16148943	SIGNOR-140238
PRKAA2	CRTC2	Ser171	SALNRTSsDSALHTS	phosphorylation down-regulates	16308421	SIGNOR-142211
PRKAA2	CRTC2	Ser171	SALNRTSsDSALHTS	phosphorylation down-regulates	20577053	SIGNOR-166365
PRKAA2	RPTOR	Ser722	PRLRSVSsYGNIRAV	phosphorylation down-regulates	18439900	SIGNOR-263045
PRKAA2	RPTOR	Ser792	LTQSAPAsPTNKGVH	phosphorylation down-regulates activity	18439900	SIGNOR-163463
PRKAA2	TSC1	–		phosphorylation up-regulates	14651849	SIGNOR-119541
PRKAA2	PROX1	Ser79	KLLKRANsYEDAMMP	phosphorylation down-regulates quantity by destabilization	36433955	SIGNOR-277608
PRKAA2	HAS2	Thr110	LQSVKRLtYPGIKVV	phosphorylation down-regulates activity	21228273	SIGNOR-276299
PRKAA2	PPP1R12C	Ser452	AGLQRSAsSSWLEGT	phosphorylation down-regulates	22137581	SIGNOR-195148
PRKAA2	HIPK2	Ser121	LMRRSTVsLLDTYQK	phosphorylation down-regulates activity	23871434	SIGNOR-275486
PRKAA2	HIPK2	Thr1116	AALGSTGtVAHLVAS	phosphorylation down-regulates activity	23871434	SIGNOR-275487
PRKAA2	HIPK2	Thr119	HNLMRRStVSLLDTY	phosphorylation down-regulates activity	23871434	SIGNOR-275485
PRKAA2	BAIAP2	Ser366	KTLPRSSsMAAGLER	phosphorylation down-regulates	19933840	SIGNOR-161810
PRKAA2	BAIAP2	Ser366	KTLPRSSsMAAGLER	phosphorylation down-regulates	22137581	SIGNOR-195102
PRKAA2	IKK-complex	–		phosphorylation up-regulates	21673972	SIGNOR-217457
PRKAA2	Gbeta	–		phosphorylation up-regulates	20647423	SIGNOR-166905

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PRKAA2	phosphorylation up-regulates →	EEF2K PSer366	phosphorylation down-regulates ⊣	EEF2K	14709557	SIGNOR-250319
PRKAA2	phosphorylation up-regulates →	EEF2K PSer78	phosphorylation down-regulates ⊣	EEF2K	14709557	SIGNOR-250321
PRKAA2	phosphorylation up-regulates →	EEF2K PSer398	phosphorylation up-regulates →	EEF2K	14709557	SIGNOR-250158
PRKAA2	phosphorylation up-regulates →	ACACB PSer222	phosphorylation down-regulates ⊣	ACACB	14613924	SIGNOR-250316
PRKAA2	phosphorylation up-regulates →	ACACB PSer222	phosphorylation down-regulates ⊣	ACACB	9148944	SIGNOR-250318
PRKAA2	phosphorylation up-regulates →	IKBKB PSer177	phosphorylation up-regulates →	IKBKB	21673972	SIGNOR-174401
PRKAA2	phosphorylation up-regulates →	IKBKB PSer181	phosphorylation up-regulates →	IKBKB	21673972	SIGNOR-174405
PRKAA2	phosphorylation up-regulates →	PFKFB2 PSer466	phosphorylation up-regulates →	PFKFB2	11069105	SIGNOR-250323
PRKAA2	phosphorylation up-regulates →	ULK1 PSer317	phosphorylation up-regulates →	ULK1	19584320	SIGNOR-186633
PRKAA2	phosphorylation up-regulates →	ULK1 PSer556	phosphorylation up-regulates →	ULK1	19584320	SIGNOR-186637
PRKAA2	phosphorylation up-regulates →	ULK1 PSer638	phosphorylation up-regulates →	ULK1	19584320	SIGNOR-186641
PRKAA2	phosphorylation up-regulates →	ULK1 PSer317	phosphorylation up-regulates →	ULK1	21205641	SIGNOR-170859
PRKAA2	phosphorylation up-regulates →	ULK1 PSer556	phosphorylation up-regulates →	ULK1	21205641	SIGNOR-170863
PRKAA2	phosphorylation up-regulates →	ULK1 PSer638	phosphorylation up-regulates →	ULK1	21205641	SIGNOR-170867
PRKAA2	phosphorylation up-regulates →	TFAP2A PSer219	phosphorylation up-regulates →	TFAP2A	22561688	SIGNOR-279648
PRKAA2	phosphorylation up-regulates →	PDHA1 PSer295	phosphorylation up-regulates →	PDHA1	33022274	SIGNOR-276840
PRKAA2	phosphorylation up-regulates →	PDHA1 PSer314	phosphorylation up-regulates →	PDHA1	33022274	SIGNOR-276838
PRKAA2	phosphorylation up-regulates →	DUSP1 PSer334	phosphorylation down-regulates ⊣	DUSP1	25799226	SIGNOR-276890
PRKAA2	phosphorylation up-regulates →	CDC27 PSer379	phosphorylation down-regulates ⊣	CDC27	22137581	SIGNOR-195106
PRKAA2	phosphorylation up-regulates →	SREBF1 PSer396	phosphorylation down-regulates ⊣	SREBF1	21459323	SIGNOR-173031
PRKAA2	phosphorylation up-regulates →	HNF4A PSer313	phosphorylation down-regulates ⊣	HNF4A	12740371	SIGNOR-250322
PRKAA2	phosphorylation up-regulates →	TSC2 PSer1387	phosphorylation up-regulates →	TSC2	16959574	SIGNOR-149388
PRKAA2	phosphorylation up-regulates →	VASP PThr278	phosphorylation down-regulates ⊣	VASP	17082196	SIGNOR-150462
PRKAA2	phosphorylation up-regulates →	VASP PSer322	phosphorylation down-regulates ⊣	VASP	21945940	SIGNOR-176642
PRKAA2	phosphorylation up-regulates →	ACACA PSer80	phosphorylation down-regulates ⊣	ACACA	12015362	SIGNOR-87583
PRKAA2	phosphorylation up-regulates →	PAK2 PSer20	phosphorylation down-regulates ⊣	PAK2	22137581	SIGNOR-195110
PRKAA2	phosphorylation up-regulates →	PLD1 PSer505	phosphorylation up-regulates →	PLD1	20231899	SIGNOR-164293
PRKAA2	phosphorylation up-regulates →	CRTC2 PSer171	phosphorylation down-regulates ⊣	CRTC2	16148943	SIGNOR-140238
PRKAA2	phosphorylation up-regulates →	CRTC2 PSer171	phosphorylation down-regulates ⊣	CRTC2	16308421	SIGNOR-142211
PRKAA2	phosphorylation up-regulates →	CRTC2 PSer171	phosphorylation down-regulates ⊣	CRTC2	20577053	SIGNOR-166365
PRKAA2	phosphorylation up-regulates →	RPTOR PSer722	phosphorylation down-regulates ⊣	RPTOR	18439900	SIGNOR-263045
PRKAA2	phosphorylation up-regulates →	RPTOR PSer792	phosphorylation down-regulates ⊣	RPTOR	18439900	SIGNOR-163463
PRKAA2	phosphorylation up-regulates →	PROX1 PSer79	phosphorylation down-regulates ⊣	PROX1	36433955	SIGNOR-277608
PRKAA2	phosphorylation up-regulates →	HAS2 PThr110	phosphorylation down-regulates ⊣	HAS2	21228273	SIGNOR-276299
PRKAA2	phosphorylation up-regulates →	PPP1R12C PSer452	phosphorylation down-regulates ⊣	PPP1R12C	22137581	SIGNOR-195148
PRKAA2	phosphorylation up-regulates →	HIPK2 PSer121	phosphorylation down-regulates ⊣	HIPK2	23871434	SIGNOR-275486
PRKAA2	phosphorylation up-regulates →	HIPK2 PThr1116	phosphorylation down-regulates ⊣	HIPK2	23871434	SIGNOR-275487
PRKAA2	phosphorylation up-regulates →	HIPK2 PThr119	phosphorylation down-regulates ⊣	HIPK2	23871434	SIGNOR-275485
PRKAA2	phosphorylation up-regulates →	BAIAP2 PSer366	phosphorylation down-regulates ⊣	BAIAP2	19933840	SIGNOR-161810
PRKAA2	phosphorylation up-regulates →	BAIAP2 PSer366	phosphorylation down-regulates ⊣	BAIAP2	22137581	SIGNOR-195102

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PRKAA2	phosphorylation → down-regulates activity	EEF2K	SIGNOR-250319
PRKAA2	phosphorylation → down-regulates activity	EEF2K	SIGNOR-250321
PRKAA2	phosphorylation → up-regulates activity	EEF2K	SIGNOR-250158
PRKAA2	phosphorylation → down-regulates activity	ACACB	SIGNOR-250316
PRKAA2	phosphorylation → down-regulates activity	ACACB	SIGNOR-250318
PRKAA2	phosphorylation → up-regulates	IKBKB	SIGNOR-174401
PRKAA2	phosphorylation → up-regulates	IKBKB	SIGNOR-174405
PRKAA2	phosphorylation → up-regulates activity	PFKFB2	SIGNOR-250323
PRKAA2	phosphorylation → up-regulates	ULK1	SIGNOR-186633
PRKAA2	phosphorylation → up-regulates	ULK1	SIGNOR-186637
PRKAA2	phosphorylation → up-regulates	ULK1	SIGNOR-186641
PRKAA2	phosphorylation → up-regulates	ULK1	SIGNOR-170859
PRKAA2	phosphorylation → up-regulates	ULK1	SIGNOR-170863
PRKAA2	phosphorylation → up-regulates	ULK1	SIGNOR-170867
PRKAA2	phosphorylation → up-regulates activity	TFAP2A	SIGNOR-279648
PRKAA2	phosphorylation → up-regulates	INSR	SIGNOR-195324
PRKAA2	phosphorylation → up-regulates activity	PDHA1	SIGNOR-276840
PRKAA2	phosphorylation → up-regulates activity	PDHA1	SIGNOR-276838
PRKAA2	phosphorylation down-regulates quantity by destabilization	DUSP1	SIGNOR-276890
PRKAA2	phosphorylation → unknown	CDC27	SIGNOR-195106
PRKAA2	phosphorylation down-regulates	SREBF1	SIGNOR-173031
PRKAA2	phosphorylation down-regulates quantity by destabilization	HNF4A	SIGNOR-250322
PRKAA2	phosphorylation → up-regulates	TSC2	SIGNOR-149388
PRKAA2	phosphorylation down-regulates	VASP	SIGNOR-150462
PRKAA2	phosphorylation down-regulates	VASP	SIGNOR-176642
PRKAA2	phosphorylation down-regulates	ACACA	SIGNOR-87583
PRKAA2	phosphorylation → unknown	PAK2	SIGNOR-195110
PRKAA2	phosphorylation → up-regulates	PLD1	SIGNOR-164293
PRKAA2	phosphorylation down-regulates	CRTC2	SIGNOR-140238
PRKAA2	phosphorylation down-regulates	CRTC2	SIGNOR-142211
PRKAA2	phosphorylation down-regulates	CRTC2	SIGNOR-166365
PRKAA2	phosphorylation down-regulates	RPTOR	SIGNOR-263045
PRKAA2	phosphorylation → down-regulates activity	RPTOR	SIGNOR-163463
PRKAA2	phosphorylation → up-regulates	TSC1	SIGNOR-119541
PRKAA2	phosphorylation down-regulates quantity by destabilization	PROX1	SIGNOR-277608
PRKAA2	phosphorylation → down-regulates activity	HAS2	SIGNOR-276299
PRKAA2	phosphorylation down-regulates	PPP1R12C	SIGNOR-195148
PRKAA2	phosphorylation → down-regulates activity	HIPK2	SIGNOR-275486
PRKAA2	phosphorylation → down-regulates activity	HIPK2	SIGNOR-275487
PRKAA2	phosphorylation → down-regulates activity	HIPK2	SIGNOR-275485
PRKAA2	phosphorylation down-regulates	BAIAP2	SIGNOR-161810
PRKAA2	phosphorylation down-regulates	BAIAP2	SIGNOR-195102
PRKAA2	phosphorylation → up-regulates	IKK-complex	SIGNOR-217457
PRKAA2	phosphorylation → up-regulates	Gbeta	SIGNOR-166905