Summary

Name PRKAA2
Full Name 5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms AMPK subunit alpha-2, Acetyl-CoA carboxylase kinase, ACACA kinase, 2.7.11.27, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, 2.7.11.31 | AMPK, AMPK2
Primary ID P54646
Links - -
Type protein
Relations 46
Function Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation TSC2 0.44
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CRTC2 0.4
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PRKAA2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IKBKB 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PAK2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ACACB 0.34
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation HNF4A 0.22
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png phosphorylation ULK1 0.66
Publications: 6 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation VASP 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAIAP2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.22
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation CDC27 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SREBF1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EEF2K 0.22
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PPP1R12C 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PFKFB2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLD1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png phosphorylation ACACA 0.31
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png phosphorylation RPTOR 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAA2 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAA2 0.48
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TSC1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation Gbeta 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding AMPK 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png PRKAA2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation INSR 0.31
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/direct_inhibition.png phosphorylation PRKAA2 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png PRKAA2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation PRKAA2 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ up-regulates img/direct-activation.png binding PRKAA2 0.47
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IKK-complex 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PRKAA2 0.14
Publications: 1 Organism: Homo Sapiens