| Name | PRKAA2 |
| ID | P54646 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 16-268 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | PRKAA2 | Thr172 | SDGEFLRtSCGSPNY | phosphorylation up-regulates activity | 23871434 | SIGNOR-275488 |
| STK11 | PRKAA2 | Thr172 | SDGEFLRtSCGSPNY | phosphorylation up-regulates | 14976552 | SIGNOR-122725 |
| ULK2 | PRKAA2 | – | phosphorylation down-regulates | 21460634 | SIGNOR-173089 | |
| ULK1 | PRKAA2 | – | phosphorylation down-regulates | 21460634 | SIGNOR-173050 | |
| SRC | PRKAA2 | Tyr179 | TSCGSPNyAAPEVIS | phosphorylation down-regulates activity | 34673141 | SIGNOR-277573 |
| CAMKK2 | PRKAA2 | Thr172 | SDGEFLRtSCGSPNY | phosphorylation up-regulates | 15980064 | SIGNOR-138364 |
| CAMKK2 | PRKAA2 | Thr172 | SDGEFLRtSCGSPNY | phosphorylation up-regulates | 19958286 | SIGNOR-161929 |
| STK11 | PRKAA2 | Thr172 | SDGEFLRtSCGSPNY | phosphorylation up-regulates | 14614828 | SIGNOR-119179 |
| CDK5 | PRKAA2 | – | phosphorylation down-regulates activity | 31786229 | SIGNOR-280218 | |
| FYN | PRKAA2 | Tyr436 | EWKVVNAyHLRVRRK | phosphorylation down-regulates activity | 27626315 | SIGNOR-277279 |
| PRKACA | PRKAA2 | Ser173 | DGEFLRTsCGSPNYA | phosphorylation down-regulates | 19942859 | SIGNOR-161860 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | PRKAA2 PThr172 | phosphorylation up-regulates → | PRKAA2 | 23871434 | SIGNOR-275488 |
| STK11 | phosphorylation up-regulates → | PRKAA2 PThr172 | phosphorylation up-regulates → | PRKAA2 | 14976552 | SIGNOR-122725 |
| SRC | phosphorylation up-regulates → | PRKAA2 PTyr179 | phosphorylation down-regulates ⊣ | PRKAA2 | 34673141 | SIGNOR-277573 |
| CAMKK2 | phosphorylation up-regulates → | PRKAA2 PThr172 | phosphorylation up-regulates → | PRKAA2 | 15980064 | SIGNOR-138364 |
| CAMKK2 | phosphorylation up-regulates → | PRKAA2 PThr172 | phosphorylation up-regulates → | PRKAA2 | 19958286 | SIGNOR-161929 |
| STK11 | phosphorylation up-regulates → | PRKAA2 PThr172 | phosphorylation up-regulates → | PRKAA2 | 14614828 | SIGNOR-119179 |
| FYN | phosphorylation up-regulates → | PRKAA2 PTyr436 | phosphorylation down-regulates ⊣ | PRKAA2 | 27626315 | SIGNOR-277279 |
| PRKACA | phosphorylation up-regulates → | PRKAA2 PSer173 | phosphorylation down-regulates ⊣ | PRKAA2 | 19942859 | SIGNOR-161860 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation → up-regulates activity | PRKAA2 | SIGNOR-275488 |
| STK11 | phosphorylation → up-regulates | PRKAA2 | SIGNOR-122725 |
| ULK2 | phosphorylation down-regulates | PRKAA2 | SIGNOR-173089 |
| ULK1 | phosphorylation down-regulates | PRKAA2 | SIGNOR-173050 |
| SRC | phosphorylation → down-regulates activity | PRKAA2 | SIGNOR-277573 |
| CAMKK2 | phosphorylation → up-regulates | PRKAA2 | SIGNOR-138364 |
| CAMKK2 | phosphorylation → up-regulates | PRKAA2 | SIGNOR-161929 |
| STK11 | phosphorylation → up-regulates | PRKAA2 | SIGNOR-119179 |
| CDK5 | phosphorylation → down-regulates activity | PRKAA2 | SIGNOR-280218 |
| FYN | phosphorylation → down-regulates activity | PRKAA2 | SIGNOR-277279 |
| PRKACA | phosphorylation down-regulates | PRKAA2 | SIGNOR-161860 |