| Name | CASP9 |
| ID | P55211 |
| Role | substrate |
| Enzymatic Domains |
CARD 1-92 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 19016842 | SIGNOR-279326 |
| AKT1 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates activity | 9812896 | SIGNOR-252581 |
| PRKACA | CASP9 | Ser99 | NRQAAKLsKPTLENL | phosphorylation down-regulates | 15703181 | SIGNOR-133888 |
| PPP1CA | CASP9 | Thr125 | PEVLRPEtPRPVDIG | dephosphorylation up-regulates | 22311969 | SIGNOR-195992 |
| ERK1/2 | CASP9 | – | phosphorylation down-regulates activity | 12792650 | SIGNOR-270184 | |
| CDK1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates | 16287866 | SIGNOR-141621 |
| Gbeta | CASP9 | – | phosphorylation down-regulates activity | 12792650 | SIGNOR-270084 | |
| MEK1/2 | CASP9 | – | phosphorylation down-regulates activity | 12792650 | SIGNOR-270222 | |
| PRKACA | CASP9 | Ser183 | GLRTRTGsNIDCEKL | phosphorylation down-regulates | 15703181 | SIGNOR-133880 |
| MAPK1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 12792650 | SIGNOR-101544 |
| MAP2K2 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 12792650 | SIGNOR-249386 |
| AKT | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates activity | 10529400 | SIGNOR-71480 |
| AKT2 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates | 15004527 | SIGNOR-123243 |
| AKT1 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates activity | 10529400 | SIGNOR-252585 |
| PRKACA | CASP9 | Ser195 | EKLRRRFsSLHFMVE | phosphorylation down-regulates | 15703181 | SIGNOR-133884 |
| AKT2 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates | 9812896 | SIGNOR-61561 |
| MAP2K1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 12792650 | SIGNOR-249385 |
| AKT3 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates | 9812896 | SIGNOR-61565 |
| SRC | CASP9 | Tyr251 | LQFPGAVyGTDGCPV | phosphorylation up-regulates activity | 29844931 | SIGNOR-272998 |
| CDK1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates | 17466630 | SIGNOR-154626 |
| CyclinB/CDK1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates | 17466630 | SIGNOR-216884 |
| MAPK3 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 12792650 | SIGNOR-101548 |
| AKT | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates activity | 9812896 | SIGNOR-251473 |
| AKT1 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates | 15004527 | SIGNOR-252472 |
| PRKCZ | CASP9 | Ser144 | GDVGALEsLRGNADL | phosphorylation down-regulates | 16287866 | SIGNOR-141629 |
| ABL1 | CASP9 | Tyr153 | LAYILSMePCGHCLI | phosphorylation up-regulates activity | 15657060 | SIGNOR-260792 |
| MAPK1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 16888006 | SIGNOR-148616 |
| ABL1 | CASP9 | Tyr153 | RGNADLAyILSMEPC | phosphorylation up-regulates | 15657060 | SIGNOR-133260 |
| CyclinB/CDK1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates | 16287866 | SIGNOR-216876 |
| PPP1CA | CASP9 | Thr125 | PEVLRPEtPRPVDIG | dephosphorylation up-regulates activity | 16888006 | SIGNOR-248565 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 19016842 | SIGNOR-279326 |
| AKT1 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 9812896 | SIGNOR-252581 |
| PRKACA | phosphorylation up-regulates → | CASP9 PSer99 | phosphorylation down-regulates ⊣ | CASP9 | 15703181 | SIGNOR-133888 |
| PPP1CA | dephosphorylation down-regulates ⊣ | CASP9 PThr125 | dephosphorylation down-regulates ⊣ | CASP9 | 22311969 | SIGNOR-195992 |
| CDK1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 16287866 | SIGNOR-141621 |
| PRKACA | phosphorylation up-regulates → | CASP9 PSer183 | phosphorylation down-regulates ⊣ | CASP9 | 15703181 | SIGNOR-133880 |
| MAPK1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 12792650 | SIGNOR-101544 |
| MAP2K2 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 12792650 | SIGNOR-249386 |
| AKT | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 10529400 | SIGNOR-71480 |
| AKT2 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 15004527 | SIGNOR-123243 |
| AKT1 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 10529400 | SIGNOR-252585 |
| PRKACA | phosphorylation up-regulates → | CASP9 PSer195 | phosphorylation down-regulates ⊣ | CASP9 | 15703181 | SIGNOR-133884 |
| AKT2 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 9812896 | SIGNOR-61561 |
| MAP2K1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 12792650 | SIGNOR-249385 |
| AKT3 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 9812896 | SIGNOR-61565 |
| SRC | phosphorylation up-regulates → | CASP9 PTyr251 | phosphorylation up-regulates → | CASP9 | 29844931 | SIGNOR-272998 |
| CDK1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 17466630 | SIGNOR-154626 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 17466630 | SIGNOR-216884 |
| MAPK3 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 12792650 | SIGNOR-101548 |
| AKT | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 9812896 | SIGNOR-251473 |
| AKT1 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 15004527 | SIGNOR-252472 |
| PRKCZ | phosphorylation up-regulates → | CASP9 PSer144 | phosphorylation down-regulates ⊣ | CASP9 | 16287866 | SIGNOR-141629 |
| ABL1 | phosphorylation up-regulates → | CASP9 PTyr153 | phosphorylation up-regulates → | CASP9 | 15657060 | SIGNOR-260792 |
| MAPK1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 16888006 | SIGNOR-148616 |
| ABL1 | phosphorylation up-regulates → | CASP9 PTyr153 | phosphorylation up-regulates → | CASP9 | 15657060 | SIGNOR-133260 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 16287866 | SIGNOR-216876 |
| PPP1CA | dephosphorylation down-regulates ⊣ | CASP9 PThr125 | dephosphorylation down-regulates ⊣ | CASP9 | 16888006 | SIGNOR-248565 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK1A | phosphorylation → down-regulates activity | CASP9 | SIGNOR-279326 |
| AKT1 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-252581 |
| PRKACA | phosphorylation down-regulates | CASP9 | SIGNOR-133888 |
| PPP1CA | dephosphorylation → up-regulates | CASP9 | SIGNOR-195992 |
| ERK1/2 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-270184 |
| CDK1 | phosphorylation down-regulates | CASP9 | SIGNOR-141621 |
| Gbeta | phosphorylation → down-regulates activity | CASP9 | SIGNOR-270084 |
| MEK1/2 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-270222 |
| PRKACA | phosphorylation down-regulates | CASP9 | SIGNOR-133880 |
| MAPK1 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-101544 |
| MAP2K2 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-249386 |
| AKT | phosphorylation → down-regulates activity | CASP9 | SIGNOR-71480 |
| AKT2 | phosphorylation down-regulates | CASP9 | SIGNOR-123243 |
| AKT1 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-252585 |
| PRKACA | phosphorylation down-regulates | CASP9 | SIGNOR-133884 |
| AKT2 | phosphorylation down-regulates | CASP9 | SIGNOR-61561 |
| MAP2K1 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-249385 |
| AKT3 | phosphorylation down-regulates | CASP9 | SIGNOR-61565 |
| SRC | phosphorylation → up-regulates activity | CASP9 | SIGNOR-272998 |
| CDK1 | phosphorylation down-regulates | CASP9 | SIGNOR-154626 |
| CyclinB/CDK1 | phosphorylation down-regulates | CASP9 | SIGNOR-216884 |
| MAPK3 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-101548 |
| AKT | phosphorylation → down-regulates activity | CASP9 | SIGNOR-251473 |
| AKT1 | phosphorylation down-regulates | CASP9 | SIGNOR-252472 |
| PRKCZ | phosphorylation down-regulates | CASP9 | SIGNOR-141629 |
| ABL1 | phosphorylation → up-regulates activity | CASP9 | SIGNOR-260792 |
| MAPK1 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-148616 |
| ABL1 | phosphorylation → up-regulates | CASP9 | SIGNOR-133260 |
| CyclinB/CDK1 | phosphorylation down-regulates | CASP9 | SIGNOR-216876 |
| PPP1CA | dephosphorylation → up-regulates activity | CASP9 | SIGNOR-248565 |