Summary

Name CASP9
Full Name Caspase-9
Synonyms CASP-9, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, APAF-3, ICE-like apoptotic protease 6, ICE-LAP6 | MCH6
Primary ID P55211
Links - -
Type protein
Relations 50
Pathways Death Receptor Signaling, Mitochondrial Control of Apoptosis, Parkinson disease, Inhibition of Apoptosis
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).; FUNCTION

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png cleavage CASP9 0.46
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Parkinson disease
+ up-regulates activity img/direct-activation.png cleavage CASP9 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.2
Publications: 2 Organism: Homo Sapiens, In Vitro
Pathways:Inhibition of Apoptosis
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.37
Publications: 2 Organism: In Vitro, Homo Sapiens
Pathways:Parkinson disease
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.37
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson disease
+ up-regulates activity img/direct-activation.png dephosphorylation CASP9 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.3
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.14
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.14
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.42
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation CASP9 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CASP9 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CASP9 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CASP9 0.81
Publications: 3 Organism: Homo Sapiens, In Vitro
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Parkinson disease
+ form complex img/form-complex.png binding Apoptosome 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding CASP9 0.42
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Mitochondrial Control of Apoptosis
+ form complex img/form-complex.png binding Caspase 9 complex 0.14
Publications: 1
+ up-regulates activity img/direct-activation.png binding CASP9 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png CASP9 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png binding CASP9 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png CASP9 0.36
Publications: 1 Organism: In Vitro
Pathways:Death Receptor Signaling, Mitochondrial Control of Apoptosis
+ down-regulates img/direct_inhibition.png binding CASP9 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CASP9 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates img/direct-activation.png cleavage CASP9 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CASP9 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Mitochondrial Control of Apoptosis
+ down-regulates img/direct_inhibition.png binding CASP9 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CASP9 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Mitochondrial Control of Apoptosis, Parkinson disease
+ down-regulates img/direct_inhibition.png binding CASP9 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage CASP3 0.66
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Parkinson disease
+ down-regulates img/direct_inhibition.png binding CASP9 0.36
Publications: 1 Organism: Homo Sapiens