| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates activity | 10529400 | SIGNOR-71480 |
| AKT3 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates | 9812896 | SIGNOR-61565 |
| AKT2 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates | 15004527 | SIGNOR-123243 |
| AKT1 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates activity | 10529400 | SIGNOR-252585 |
| AKT2 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates | 9812896 | SIGNOR-61561 |
| AKT | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates activity | 9812896 | SIGNOR-251473 |
| AKT1 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates | 15004527 | SIGNOR-252472 |
| AKT1 | CASP9 | Ser196 | KLRRRFSsLHFMVEV | phosphorylation down-regulates activity | 9812896 | SIGNOR-252581 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 10529400 | SIGNOR-71480 |
| AKT3 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 9812896 | SIGNOR-61565 |
| AKT2 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 15004527 | SIGNOR-123243 |
| AKT1 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 10529400 | SIGNOR-252585 |
| AKT2 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 9812896 | SIGNOR-61561 |
| AKT | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 9812896 | SIGNOR-251473 |
| AKT1 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 15004527 | SIGNOR-252472 |
| AKT1 | phosphorylation up-regulates → | CASP9 PSer196 | phosphorylation down-regulates ⊣ | CASP9 | 9812896 | SIGNOR-252581 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → down-regulates activity | CASP9 | SIGNOR-71480 |
| AKT3 | phosphorylation down-regulates | CASP9 | SIGNOR-61565 |
| AKT2 | phosphorylation down-regulates | CASP9 | SIGNOR-123243 |
| AKT1 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-252585 |
| AKT2 | phosphorylation down-regulates | CASP9 | SIGNOR-61561 |
| AKT | phosphorylation → down-regulates activity | CASP9 | SIGNOR-251473 |
| AKT1 | phosphorylation down-regulates | CASP9 | SIGNOR-252472 |
| AKT1 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-252581 |
