Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAP2K1	CASP9	Thr125 View in OncoXplorer	PEVLRPEtPRPVDIG	phosphorylation down-regulates activity	12792650	SIGNOR-249385
CyclinB/CDK1	CASP9	Thr125 View in OncoXplorer	PEVLRPEtPRPVDIG	phosphorylation down-regulates	16287866	SIGNOR-216876
MAPK1	CASP9	Thr125 View in OncoXplorer	PEVLRPEtPRPVDIG	phosphorylation down-regulates activity	16888006	SIGNOR-148616
MAP2K2	CASP9	Thr125 View in OncoXplorer	PEVLRPEtPRPVDIG	phosphorylation down-regulates activity	12792650	SIGNOR-249386
DYRK1A	CASP9	Thr125 View in OncoXplorer	PEVLRPEtPRPVDIG	phosphorylation down-regulates activity	19016842	SIGNOR-279326
MAPK1	CASP9	Thr125 View in OncoXplorer	PEVLRPEtPRPVDIG	phosphorylation down-regulates activity	12792650	SIGNOR-101544
PPP1CA	CASP9	Thr125 View in OncoXplorer	PEVLRPEtPRPVDIG	dephosphorylation up-regulates activity	16888006	SIGNOR-248565
CDK1	CASP9	Thr125 View in OncoXplorer	PEVLRPEtPRPVDIG	phosphorylation down-regulates	17466630	SIGNOR-154626
PPP1CA	CASP9	Thr125 View in OncoXplorer	PEVLRPEtPRPVDIG	dephosphorylation up-regulates	22311969	SIGNOR-195992
MAPK3	CASP9	Thr125 View in OncoXplorer	PEVLRPEtPRPVDIG	phosphorylation down-regulates activity	12792650	SIGNOR-101548
CDK1	CASP9	Thr125 View in OncoXplorer	PEVLRPEtPRPVDIG	phosphorylation down-regulates	16287866	SIGNOR-141621
CyclinB/CDK1	CASP9	Thr125 View in OncoXplorer	PEVLRPEtPRPVDIG	phosphorylation down-regulates	17466630	SIGNOR-216884

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAP2K1	phosphorylation up-regulates →	CASP9 PThr125	phosphorylation down-regulates ⊣	CASP9	12792650	SIGNOR-249385
CyclinB/CDK1	phosphorylation up-regulates →	CASP9 PThr125	phosphorylation down-regulates ⊣	CASP9	16287866	SIGNOR-216876
MAPK1	phosphorylation up-regulates →	CASP9 PThr125	phosphorylation down-regulates ⊣	CASP9	16888006	SIGNOR-148616
MAP2K2	phosphorylation up-regulates →	CASP9 PThr125	phosphorylation down-regulates ⊣	CASP9	12792650	SIGNOR-249386
DYRK1A	phosphorylation up-regulates →	CASP9 PThr125	phosphorylation down-regulates ⊣	CASP9	19016842	SIGNOR-279326
MAPK1	phosphorylation up-regulates →	CASP9 PThr125	phosphorylation down-regulates ⊣	CASP9	12792650	SIGNOR-101544
PPP1CA	dephosphorylation down-regulates ⊣	CASP9 PThr125	dephosphorylation down-regulates ⊣	CASP9	16888006	SIGNOR-248565
CDK1	phosphorylation up-regulates →	CASP9 PThr125	phosphorylation down-regulates ⊣	CASP9	17466630	SIGNOR-154626
PPP1CA	dephosphorylation down-regulates ⊣	CASP9 PThr125	dephosphorylation down-regulates ⊣	CASP9	22311969	SIGNOR-195992
MAPK3	phosphorylation up-regulates →	CASP9 PThr125	phosphorylation down-regulates ⊣	CASP9	12792650	SIGNOR-101548
CDK1	phosphorylation up-regulates →	CASP9 PThr125	phosphorylation down-regulates ⊣	CASP9	16287866	SIGNOR-141621
CyclinB/CDK1	phosphorylation up-regulates →	CASP9 PThr125	phosphorylation down-regulates ⊣	CASP9	17466630	SIGNOR-216884

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAP2K1	phosphorylation → down-regulates activity	CASP9	SIGNOR-249385
CyclinB/CDK1	phosphorylation down-regulates	CASP9	SIGNOR-216876
MAPK1	phosphorylation → down-regulates activity	CASP9	SIGNOR-148616
MAP2K2	phosphorylation → down-regulates activity	CASP9	SIGNOR-249386
DYRK1A	phosphorylation → down-regulates activity	CASP9	SIGNOR-279326
MAPK1	phosphorylation → down-regulates activity	CASP9	SIGNOR-101544
PPP1CA	dephosphorylation → up-regulates activity	CASP9	SIGNOR-248565
CDK1	phosphorylation down-regulates	CASP9	SIGNOR-154626
PPP1CA	dephosphorylation → up-regulates	CASP9	SIGNOR-195992
MAPK3	phosphorylation → down-regulates activity	CASP9	SIGNOR-101548
CDK1	phosphorylation down-regulates	CASP9	SIGNOR-141621
CyclinB/CDK1	phosphorylation down-regulates	CASP9	SIGNOR-216884