| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates | 16287866 | SIGNOR-216876 |
| PPP1CA | CASP9 | Thr125 | PEVLRPEtPRPVDIG | dephosphorylation up-regulates activity | 16888006 | SIGNOR-248565 |
| CDK1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates | 17466630 | SIGNOR-154626 |
| CyclinB/CDK1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates | 17466630 | SIGNOR-216884 |
| MAPK3 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 12792650 | SIGNOR-101548 |
| MAPK1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 16888006 | SIGNOR-148616 |
| DYRK1A | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 19016842 | SIGNOR-279326 |
| PPP1CA | CASP9 | Thr125 | PEVLRPEtPRPVDIG | dephosphorylation up-regulates | 22311969 | SIGNOR-195992 |
| CDK1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates | 16287866 | SIGNOR-141621 |
| MAPK1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 12792650 | SIGNOR-101544 |
| MAP2K2 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 12792650 | SIGNOR-249386 |
| MAP2K1 | CASP9 | Thr125 | PEVLRPEtPRPVDIG | phosphorylation down-regulates activity | 12792650 | SIGNOR-249385 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 16287866 | SIGNOR-216876 |
| PPP1CA | dephosphorylation down-regulates ⊣ | CASP9 PThr125 | dephosphorylation down-regulates ⊣ | CASP9 | 16888006 | SIGNOR-248565 |
| CDK1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 17466630 | SIGNOR-154626 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 17466630 | SIGNOR-216884 |
| MAPK3 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 12792650 | SIGNOR-101548 |
| MAPK1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 16888006 | SIGNOR-148616 |
| DYRK1A | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 19016842 | SIGNOR-279326 |
| PPP1CA | dephosphorylation down-regulates ⊣ | CASP9 PThr125 | dephosphorylation down-regulates ⊣ | CASP9 | 22311969 | SIGNOR-195992 |
| CDK1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 16287866 | SIGNOR-141621 |
| MAPK1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 12792650 | SIGNOR-101544 |
| MAP2K2 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 12792650 | SIGNOR-249386 |
| MAP2K1 | phosphorylation up-regulates → | CASP9 PThr125 | phosphorylation down-regulates ⊣ | CASP9 | 12792650 | SIGNOR-249385 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinB/CDK1 | phosphorylation down-regulates | CASP9 | SIGNOR-216876 |
| PPP1CA | dephosphorylation → up-regulates activity | CASP9 | SIGNOR-248565 |
| CDK1 | phosphorylation down-regulates | CASP9 | SIGNOR-154626 |
| CyclinB/CDK1 | phosphorylation down-regulates | CASP9 | SIGNOR-216884 |
| MAPK3 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-101548 |
| MAPK1 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-148616 |
| DYRK1A | phosphorylation → down-regulates activity | CASP9 | SIGNOR-279326 |
| PPP1CA | dephosphorylation → up-regulates | CASP9 | SIGNOR-195992 |
| CDK1 | phosphorylation down-regulates | CASP9 | SIGNOR-141621 |
| MAPK1 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-101544 |
| MAP2K2 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-249386 |
| MAP2K1 | phosphorylation → down-regulates activity | CASP9 | SIGNOR-249385 |
