| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | HDAC4 | – | phosphorylation up-regulates activity | 30661366 | SIGNOR-277424 | |
| PRKAA1 | HDAC4 | – | phosphorylation down-regulates | 21565617 | SIGNOR-173689 | |
| PKA | HDAC4 | – | phosphorylation up-regulates activity | 30661366 | SIGNOR-277425 | |
| PPP2CA | HDAC4 | Ser298 | ACSSAPGsGPSSPNN | dephosphorylation up-regulates | 18045992 | SIGNOR-159492 |
| SIK3 | HDAC4 | – | phosphorylation down-regulates activity | 21565608 | SIGNOR-279430 | |
| GSK3B | HDAC4 | Ser302 | APGSGPSsPNNSSGS | phosphorylation down-regulates | 21118993 | SIGNOR-170148 |
| CAMK4 | HDAC4 | – | phosphorylation down-regulates | 11062529 | SIGNOR-83837 | |
| AURKB | HDAC4 | Ser265 | QKVAERRsSPLLRRK | phosphorylation down-regulates | 22865920 | SIGNOR-198646 |
| CAMK2D | HDAC4 | Ser210 | YGKTQHSsLDQSSPP | phosphorylation up-regulates | 17179159 | SIGNOR-151418 |
| CAMK4 | HDAC4 | Ser467 | RPLGRTQsAPLPQNA | phosphorylation down-regulates activity | 11470791 | SIGNOR-250711 |
| AMPK | HDAC4 | – | phosphorylation down-regulates | 21565617 | SIGNOR-216658 | |
| CAMK4 | HDAC4 | Ser632 | RPLSRAQsSPASATF | phosphorylation down-regulates activity | 11470791 | SIGNOR-250712 |
| GSK3B | HDAC4 | Ser298 | ACSSAPGsGPSSPNN | phosphorylation down-regulates | 21118993 | SIGNOR-170144 |
| PKA | HDAC4 | Ser584 | EPGQRQPsEQELLFR | phosphorylation up-regulates activity | 30661366 | SIGNOR-277423 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC4 PSer298 | dephosphorylation down-regulates ⊣ | HDAC4 | 18045992 | SIGNOR-159492 |
| GSK3B | phosphorylation up-regulates → | HDAC4 PSer302 | phosphorylation down-regulates ⊣ | HDAC4 | 21118993 | SIGNOR-170148 |
| AURKB | phosphorylation up-regulates → | HDAC4 PSer265 | phosphorylation down-regulates ⊣ | HDAC4 | 22865920 | SIGNOR-198646 |
| CAMK2D | phosphorylation up-regulates → | HDAC4 PSer210 | phosphorylation up-regulates → | HDAC4 | 17179159 | SIGNOR-151418 |
| CAMK4 | phosphorylation up-regulates → | HDAC4 PSer467 | phosphorylation down-regulates ⊣ | HDAC4 | 11470791 | SIGNOR-250711 |
| CAMK4 | phosphorylation up-regulates → | HDAC4 PSer632 | phosphorylation down-regulates ⊣ | HDAC4 | 11470791 | SIGNOR-250712 |
| GSK3B | phosphorylation up-regulates → | HDAC4 PSer298 | phosphorylation down-regulates ⊣ | HDAC4 | 21118993 | SIGNOR-170144 |
| PKA | phosphorylation up-regulates → | HDAC4 PSer584 | phosphorylation up-regulates → | HDAC4 | 30661366 | SIGNOR-277423 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → up-regulates activity | HDAC4 | SIGNOR-277424 |
| PRKAA1 | phosphorylation down-regulates | HDAC4 | SIGNOR-173689 |
| PKA | phosphorylation → up-regulates activity | HDAC4 | SIGNOR-277425 |
| PPP2CA | dephosphorylation → up-regulates | HDAC4 | SIGNOR-159492 |
| SIK3 | phosphorylation → down-regulates activity | HDAC4 | SIGNOR-279430 |
| GSK3B | phosphorylation down-regulates | HDAC4 | SIGNOR-170148 |
| CAMK4 | phosphorylation down-regulates | HDAC4 | SIGNOR-83837 |
| AURKB | phosphorylation down-regulates | HDAC4 | SIGNOR-198646 |
| CAMK2D | phosphorylation → up-regulates | HDAC4 | SIGNOR-151418 |
| CAMK4 | phosphorylation → down-regulates activity | HDAC4 | SIGNOR-250711 |
| AMPK | phosphorylation down-regulates | HDAC4 | SIGNOR-216658 |
| CAMK4 | phosphorylation → down-regulates activity | HDAC4 | SIGNOR-250712 |
| GSK3B | phosphorylation down-regulates | HDAC4 | SIGNOR-170144 |
| PKA | phosphorylation → up-regulates activity | HDAC4 | SIGNOR-277423 |
