Summary

Name HDAC4
Full Name Histone deacetylase 4
Synonyms HD4 | KIAA0288
Primary ID P56524
Links - -
Type protein
Relations 20
Pathways IGF and Myogenesis
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation HDAC4 0.53
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png phosphorylation HDAC4 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC4 0.24
Publications: 2 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png dephosphorylation HDAC4 0.29
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HDAC4 0.23
Publications: 2
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png binding MEF2A 0.80
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png binding MEF2C 0.79
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png binding MEF2D 0.79
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ down-regulates activity img/direct_inhibition.png deacetylation, binding RUNX2 0.32
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation HDAC4 0.38
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png binding HDAC4 0.18
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC4 0.23
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png deacetylation RUNX2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC4
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP13 0.15
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HOXB13 0.20
Publications: 1 Organism: Homo Sapiens