| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | HDAC4 | Ser298 | ACSSAPGsGPSSPNN | dephosphorylation up-regulates | 18045992 | SIGNOR-159492 |
| GSK3B | HDAC4 | Ser298 | ACSSAPGsGPSSPNN | phosphorylation down-regulates | 21118993 | SIGNOR-170144 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | HDAC4 PSer298 | dephosphorylation down-regulates ⊣ | HDAC4 | 18045992 | SIGNOR-159492 |
| GSK3B | phosphorylation up-regulates → | HDAC4 PSer298 | phosphorylation down-regulates ⊣ | HDAC4 | 21118993 | SIGNOR-170144 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation → up-regulates | HDAC4 | SIGNOR-159492 |
| GSK3B | phosphorylation down-regulates | HDAC4 | SIGNOR-170144 |
