Entity Details

Name BACE1
ID P56817
Role substrate
Enzymatic Domains
Peptidase A1 75-416
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK5/CDK5R1BACE1Thr252YTGSLWYtPIRREWYphosphorylation
up-regulates activity		26317805SIGNOR-276934
CSNK1DBACE1Ser498DDFADDIsLLKphosphorylation
unknown		11278841SIGNOR-250797
CDK5BACE1Thr252YTGSLWYtPIRREWYphosphorylation
up-regulates activity		26317805SIGNOR-278249
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK5/CDK5R1phosphorylation
up-regulates
→
BACE1
PThr252		phosphorylation
up-regulates
→		BACE126317805SIGNOR-276934
CSNK1Dphosphorylation
up-regulates
→
BACE1
PSer498		phosphorylation
down-regulates
⊣		BACE111278841SIGNOR-250797
CDK5phosphorylation
up-regulates
→
BACE1
PThr252		phosphorylation
up-regulates
→		BACE126317805SIGNOR-278249
Regulator Mechanism/Effect Target SIGNOR-ID
CDK5/CDK5R1phosphorylation
→
up-regulates activity 		BACE1SIGNOR-276934
CSNK1Dphosphorylation
→
unknown 		BACE1SIGNOR-250797
CDK5phosphorylation
→
up-regulates activity 		BACE1SIGNOR-278249