Summary

Name BACE1
Full Name Beta-secretase 1
Synonyms Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2 | BACE, KIAA1149
Primary ID P56817
Links - -
Type protein
Relations 10
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:10656250, PubMed:10677483, PubMed:20354142). Cleaves CHL1 (By similarity).

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Relations


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Regulator Mechanism target score ℹ
+ BACE1up-regulates activity img/direct-activation.png cleavage APP 0.806
Publications: 2 Organism: Homo Sapiens,
+ USP8up-regulates quantity by stabilization img/direct-activation.png deubiquitination BACE1 0.44
Publications: 1 Organism: Homo Sapiens
+ CSNK1D