| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | RHOA | Ser188 | ARRGKKKsGCLVL | phosphorylation down-regulates activity | 12654918 | SIGNOR-250047 |
| SRC | RHOA | Tyr66 | DTAGQEDyDRLRPLS | phosphorylation down-regulates activity | 23027962 | SIGNOR-271701 |
| BCR-ABL | RHOA | Tyr66 | DTAGQEDyDRLRPLS | phosphorylation down-regulates activity | 23027962 | SIGNOR-271699 |
| ERK1/2 | RHOA | Ser88 | LMCFSIDsPDSLENI | phosphorylation up-regulates activity | 26816343 | SIGNOR-277202 |
| BCR-ABL | RHOA | Tyr34 | KDQFPEVyVPTVFEN | phosphorylation down-regulates activity | 23027962 | SIGNOR-271700 |
| SRC | RHOA | Tyr34 | KDQFPEVyVPTVFEN | phosphorylation down-regulates activity | 23027962 | SIGNOR-271702 |
| PRKCE | RHOA | Ser188 | ARRGKKKsGCLVL | phosphorylation up-regulates activity | 24191200 | SIGNOR-279477 |
| PRKCE | RHOA | Thr127 | DLRNDEHtRRELAKM | phosphorylation up-regulates activity | 24191200 | SIGNOR-279478 |
| ERK1/2 | RHOA | Thr100 | ENIPEKWtPEVKHFC | phosphorylation up-regulates activity | 26816343 | SIGNOR-277203 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | RHOA PSer188 | phosphorylation down-regulates ⊣ | RHOA | 12654918 | SIGNOR-250047 |
| SRC | phosphorylation up-regulates → | RHOA PTyr66 | phosphorylation down-regulates ⊣ | RHOA | 23027962 | SIGNOR-271701 |
| BCR-ABL | phosphorylation up-regulates → | RHOA PTyr66 | phosphorylation down-regulates ⊣ | RHOA | 23027962 | SIGNOR-271699 |
| ERK1/2 | phosphorylation up-regulates → | RHOA PSer88 | phosphorylation up-regulates → | RHOA | 26816343 | SIGNOR-277202 |
| BCR-ABL | phosphorylation up-regulates → | RHOA PTyr34 | phosphorylation down-regulates ⊣ | RHOA | 23027962 | SIGNOR-271700 |
| SRC | phosphorylation up-regulates → | RHOA PTyr34 | phosphorylation down-regulates ⊣ | RHOA | 23027962 | SIGNOR-271702 |
| PRKCE | phosphorylation up-regulates → | RHOA PSer188 | phosphorylation up-regulates → | RHOA | 24191200 | SIGNOR-279477 |
| PRKCE | phosphorylation up-regulates → | RHOA PThr127 | phosphorylation up-regulates → | RHOA | 24191200 | SIGNOR-279478 |
| ERK1/2 | phosphorylation up-regulates → | RHOA PThr100 | phosphorylation up-regulates → | RHOA | 26816343 | SIGNOR-277203 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → down-regulates activity | RHOA | SIGNOR-250047 |
| SRC | phosphorylation → down-regulates activity | RHOA | SIGNOR-271701 |
| BCR-ABL | phosphorylation → down-regulates activity | RHOA | SIGNOR-271699 |
| ERK1/2 | phosphorylation → up-regulates activity | RHOA | SIGNOR-277202 |
| BCR-ABL | phosphorylation → down-regulates activity | RHOA | SIGNOR-271700 |
| SRC | phosphorylation → down-regulates activity | RHOA | SIGNOR-271702 |
| PRKCE | phosphorylation → up-regulates activity | RHOA | SIGNOR-279477 |
| PRKCE | phosphorylation → up-regulates activity | RHOA | SIGNOR-279478 |
| ERK1/2 | phosphorylation → up-regulates activity | RHOA | SIGNOR-277203 |
