| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | AURKA | – | dephosphorylation down-regulates | 11551964 | SIGNOR-110411 | |
| PPP1CA | AXIN1 | Ser217 | YTRTGSEsPKVCSDQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248553 |
| PPP1CA | AXIN1 | Ser469 | AHEENPEsILDEHVQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248554 |
| PPP1CA | AXIN1 | Ser75 | LGYEPEGsASPTPPY | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248551 |
| PPP1CA | AXIN1 | Ser77 | YEPEGSAsPTPPYLK | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248552 |
| PPP1CA | AHCYL1 | Ser68 | RSLSRSIsQSSTDSY | dephosphorylation unknown | 17635105 | SIGNOR-248555 |
| PPP1CA | DDX58 | Ser8 | MTTEQRRsLQAFQDY | dephosphorylation up-regulates activity | 23499489 | SIGNOR-264581 |
| PPP1CA | RAF1 | Ser259 | SQRQRSTsTPNVHMV | dephosphorylation up-regulates activity | 16630891 | SIGNOR-251649 |
| PPP1CA | NR3C1 | – | dephosphorylation up-regulates activity | 32585168 | SIGNOR-277161 | |
| PPP1CA | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248556 |
| PPP1CA | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248557 |
| PPP1CA | PFN1 | Ser138 | MASHLRRsQY | dephosphorylation up-regulates | 22479341 | SIGNOR-196816 |
| PPP1CA | SP1 | – | dephosphorylation down-regulates activity | 12684058 | SIGNOR-251952 | |
| PPP1CA | BRAF | – | dephosphorylation up-regulates activity | 29335436 | SIGNOR-277160 | |
| PPP1CA | MAPK3 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-103155 | |
| PPP1CA | CAD | Ser1406 | CSGAGGRrLSSFVTK | dephosphorylation down-regulates activity | 4092695 | SIGNOR-263741 |
| PPP1CA | MAPK1 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-103152 | |
| PPP1CA | NOS3 | Thr495 | TGITRKKtFKEVANA | dephosphorylation up-regulates activity | 19036824 | SIGNOR-248558 |
| PPP1CA | CCND3 | Thr283 | QGPSQTStPTDVTAI | dephosphorylation up-regulates | 16331257 | SIGNOR-142884 |
| PPP1CA | AKT1 | Thr450 | TAQMITItPPDQDDS | dephosphorylation down-regulates | 20186153 | SIGNOR-163961 |
| PPP1CA | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-252603 |
| PPP1CA | BRCA1 | Ser1423 | AVLEQHGsQPSNSYP | dephosphorylation down-regulates activity | 17603999 | SIGNOR-248561 |
| PPP1CA | BRCA1 | Ser1524 | LQNRNYPsQEELIKV | dephosphorylation down-regulates activity | 17603999 | SIGNOR-248562 |
| PPP1CA | BRCA1 | Ser988 | PPLFPIKsFVKTKCK | dephosphorylation down-regulates activity | 17603999 | SIGNOR-248560 |
| PPP1CA | STAT3 | Ser727 | NTIDLPMsPRTLDSL | dephosphorylation down-regulates activity | 19440292 | SIGNOR-248563 |
| PPP1CA | CASP2 | Ser164 | STDTVEHsLDNKDGP | dephosphorylation up-regulates activity | 19531356 | SIGNOR-248564 |
| PPP1CA | YAP1 | Ser127 | PQHVRAHsSPASLQL | dephosphorylation up-regulates activity | 21909427 | SIGNOR-276999 |
| PPP1CA | NEK2 | – | dephosphorylation down-regulates | 17283141 | SIGNOR-152949 | |
| PPP1CA | CASP9 | Thr125 | PEVLRPEtPRPVDIG | dephosphorylation up-regulates | 22311969 | SIGNOR-195992 |
| PPP1CA | CASP9 | Thr125 | PEVLRPEtPRPVDIG | dephosphorylation up-regulates activity | 16888006 | SIGNOR-248565 |
| PPP1CA | MDM2 | Ser370 | KKTIVNDsRESCVEE | dephosphorylation up-regulates quantity by stabilization | 23277204 | SIGNOR-248566 |
| PPP1CA | SP3 | – | dephosphorylation down-regulates activity | 12684058 | SIGNOR-251953 | |
| PPP1CA | MECOM | Ser1037 | IGNSNHGsQSPRNVE | dephosphorylation down-regulates activity | 23858473 | SIGNOR-273429 |
| PPP1CA | MECOM | Ser726 | PLKMEPQsPGEVKKL | dephosphorylation down-regulates activity | 23858473 | SIGNOR-273430 |
| PPP1CA | TRIM28 | Ser824 | LPGAGLSsQELSGGP | dephosphorylation up-regulates activity | 20424263 | SIGNOR-277075 |
| PPP1CA | IKZF1 | – | dephosphorylation up-regulates | 21750978 | SIGNOR-174859 | |
| PPP1CA | PREX2 | Ser1107 | DTISNRDsYSDCNSN | dephosphorylation up-regulates activity | 26438819 | SIGNOR-277183 |
| PPP1CA | PREX1 | Ser1001 | IRFGRKPsLIGLDPE | dephosphorylation up-regulates activity | 22242915 | SIGNOR-277024 |
| PPP1CA | PREX1 | Ser1165 | DSGHDTMsYRDSYSE | dephosphorylation up-regulates activity | 22242915 | SIGNOR-277023 |
| PPP1CA | PREX1 | Ser834 | LSLGPRLsLCEDSPM | dephosphorylation up-regulates activity | 22242915 | SIGNOR-277022 |
| PPP1CA | IFIH1 | Ser88 | EALRRTGsPLAARYM | dephosphorylation up-regulates activity | 23499489 | SIGNOR-264577 |
| PPP1CA | WWTR1 | Ser311 | PYHSREQsTDSGLGL | dephosphorylation up-regulates activity | 21189257 | SIGNOR-277115 |
| PPP1CA | WWTR1 | Ser89 | AQHVRSHsSPASLQL | dephosphorylation up-regulates activity | 21189257 | SIGNOR-277116 |
| PPP1CA | ERK1/2 | – | dephosphorylation down-regulates | 12840032 | SIGNOR-269927 | |
| PPP1CA | AKT | – | dephosphorylation down-regulates | 20186153 | SIGNOR-244436 | |
| PPP1CA | AKT | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates activity | 14633703 | SIGNOR-248559 |
| PPP1CA | Gbeta | – | dephosphorylation down-regulates | 12840032 | SIGNOR-269906 | |
| PPP1CA | NMDA | – | dephosphorylation down-regulates activity | 14751588 | SIGNOR-265061 | |
| PPP1CA | AMPA | – | dephosphorylation down-regulates activity | 14751588 | SIGNOR-265060 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | dephosphorylation down-regulates ⊣ | AXIN1 PSer217 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248553 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AXIN1 PSer469 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248554 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AXIN1 PSer75 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248551 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AXIN1 PSer77 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248552 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AHCYL1 PSer68 | dephosphorylation up-regulates → | AHCYL1 | 17635105 | SIGNOR-248555 |
| PPP1CA | dephosphorylation down-regulates ⊣ | DDX58 PSer8 | dephosphorylation down-regulates ⊣ | DDX58 | 23499489 | SIGNOR-264581 |
| PPP1CA | dephosphorylation down-regulates ⊣ | RAF1 PSer259 | dephosphorylation down-regulates ⊣ | RAF1 | 16630891 | SIGNOR-251649 |
| PPP1CA | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248556 |
| PPP1CA | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248557 |
| PPP1CA | dephosphorylation down-regulates ⊣ | PFN1 PSer138 | dephosphorylation down-regulates ⊣ | PFN1 | 22479341 | SIGNOR-196816 |
| PPP1CA | dephosphorylation down-regulates ⊣ | CAD PSer1406 | dephosphorylation up-regulates → | CAD | 4092695 | SIGNOR-263741 |
| PPP1CA | dephosphorylation down-regulates ⊣ | NOS3 PThr495 | dephosphorylation down-regulates ⊣ | NOS3 | 19036824 | SIGNOR-248558 |
| PPP1CA | dephosphorylation down-regulates ⊣ | CCND3 PThr283 | dephosphorylation down-regulates ⊣ | CCND3 | 16331257 | SIGNOR-142884 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AKT1 PThr450 | dephosphorylation up-regulates → | AKT1 | 20186153 | SIGNOR-163961 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 14633703 | SIGNOR-252603 |
| PPP1CA | dephosphorylation down-regulates ⊣ | BRCA1 PSer1423 | dephosphorylation up-regulates → | BRCA1 | 17603999 | SIGNOR-248561 |
| PPP1CA | dephosphorylation down-regulates ⊣ | BRCA1 PSer1524 | dephosphorylation up-regulates → | BRCA1 | 17603999 | SIGNOR-248562 |
| PPP1CA | dephosphorylation down-regulates ⊣ | BRCA1 PSer988 | dephosphorylation up-regulates → | BRCA1 | 17603999 | SIGNOR-248560 |
| PPP1CA | dephosphorylation down-regulates ⊣ | STAT3 PSer727 | dephosphorylation up-regulates → | STAT3 | 19440292 | SIGNOR-248563 |
| PPP1CA | dephosphorylation down-regulates ⊣ | CASP2 PSer164 | dephosphorylation down-regulates ⊣ | CASP2 | 19531356 | SIGNOR-248564 |
| PPP1CA | dephosphorylation down-regulates ⊣ | YAP1 PSer127 | dephosphorylation down-regulates ⊣ | YAP1 | 21909427 | SIGNOR-276999 |
| PPP1CA | dephosphorylation down-regulates ⊣ | CASP9 PThr125 | dephosphorylation down-regulates ⊣ | CASP9 | 22311969 | SIGNOR-195992 |
| PPP1CA | dephosphorylation down-regulates ⊣ | CASP9 PThr125 | dephosphorylation down-regulates ⊣ | CASP9 | 16888006 | SIGNOR-248565 |
| PPP1CA | dephosphorylation down-regulates ⊣ | MDM2 PSer370 | dephosphorylation down-regulates ⊣ | MDM2 | 23277204 | SIGNOR-248566 |
| PPP1CA | dephosphorylation down-regulates ⊣ | MECOM PSer1037 | dephosphorylation up-regulates → | MECOM | 23858473 | SIGNOR-273429 |
| PPP1CA | dephosphorylation down-regulates ⊣ | MECOM PSer726 | dephosphorylation up-regulates → | MECOM | 23858473 | SIGNOR-273430 |
| PPP1CA | dephosphorylation down-regulates ⊣ | TRIM28 PSer824 | dephosphorylation down-regulates ⊣ | TRIM28 | 20424263 | SIGNOR-277075 |
| PPP1CA | dephosphorylation down-regulates ⊣ | PREX2 PSer1107 | dephosphorylation down-regulates ⊣ | PREX2 | 26438819 | SIGNOR-277183 |
| PPP1CA | dephosphorylation down-regulates ⊣ | PREX1 PSer1001 | dephosphorylation down-regulates ⊣ | PREX1 | 22242915 | SIGNOR-277024 |
| PPP1CA | dephosphorylation down-regulates ⊣ | PREX1 PSer1165 | dephosphorylation down-regulates ⊣ | PREX1 | 22242915 | SIGNOR-277023 |
| PPP1CA | dephosphorylation down-regulates ⊣ | PREX1 PSer834 | dephosphorylation down-regulates ⊣ | PREX1 | 22242915 | SIGNOR-277022 |
| PPP1CA | dephosphorylation down-regulates ⊣ | IFIH1 PSer88 | dephosphorylation down-regulates ⊣ | IFIH1 | 23499489 | SIGNOR-264577 |
| PPP1CA | dephosphorylation down-regulates ⊣ | WWTR1 PSer311 | dephosphorylation down-regulates ⊣ | WWTR1 | 21189257 | SIGNOR-277115 |
| PPP1CA | dephosphorylation down-regulates ⊣ | WWTR1 PSer89 | dephosphorylation down-regulates ⊣ | WWTR1 | 21189257 | SIGNOR-277116 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AKT PSer473 | dephosphorylation up-regulates → | AKT | 14633703 | SIGNOR-248559 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP1CA | dephosphorylation down-regulates | AURKA | SIGNOR-110411 |
| PPP1CA | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248553 |
| PPP1CA | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248554 |
| PPP1CA | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248551 |
| PPP1CA | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248552 |
| PPP1CA | dephosphorylation → unknown | AHCYL1 | SIGNOR-248555 |
| PPP1CA | dephosphorylation → up-regulates activity | DDX58 | SIGNOR-264581 |
| PPP1CA | dephosphorylation → up-regulates activity | RAF1 | SIGNOR-251649 |
| PPP1CA | dephosphorylation → up-regulates activity | NR3C1 | SIGNOR-277161 |
| PPP1CA | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248556 |
| PPP1CA | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248557 |
| PPP1CA | dephosphorylation → up-regulates | PFN1 | SIGNOR-196816 |
| PPP1CA | dephosphorylation → down-regulates activity | SP1 | SIGNOR-251952 |
| PPP1CA | dephosphorylation → up-regulates activity | BRAF | SIGNOR-277160 |
| PPP1CA | dephosphorylation down-regulates | MAPK3 | SIGNOR-103155 |
| PPP1CA | dephosphorylation → down-regulates activity | CAD | SIGNOR-263741 |
| PPP1CA | dephosphorylation down-regulates | MAPK1 | SIGNOR-103152 |
| PPP1CA | dephosphorylation → up-regulates activity | NOS3 | SIGNOR-248558 |
| PPP1CA | dephosphorylation → up-regulates | CCND3 | SIGNOR-142884 |
| PPP1CA | dephosphorylation down-regulates | AKT1 | SIGNOR-163961 |
| PPP1CA | dephosphorylation → down-regulates activity | AKT1 | SIGNOR-252603 |
| PPP1CA | dephosphorylation → down-regulates activity | BRCA1 | SIGNOR-248561 |
| PPP1CA | dephosphorylation → down-regulates activity | BRCA1 | SIGNOR-248562 |
| PPP1CA | dephosphorylation → down-regulates activity | BRCA1 | SIGNOR-248560 |
| PPP1CA | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-248563 |
| PPP1CA | dephosphorylation → up-regulates activity | CASP2 | SIGNOR-248564 |
| PPP1CA | dephosphorylation → up-regulates activity | YAP1 | SIGNOR-276999 |
| PPP1CA | dephosphorylation down-regulates | NEK2 | SIGNOR-152949 |
| PPP1CA | dephosphorylation → up-regulates | CASP9 | SIGNOR-195992 |
| PPP1CA | dephosphorylation → up-regulates activity | CASP9 | SIGNOR-248565 |
| PPP1CA | dephosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-248566 |
| PPP1CA | dephosphorylation → down-regulates activity | SP3 | SIGNOR-251953 |
| PPP1CA | dephosphorylation → down-regulates activity | MECOM | SIGNOR-273429 |
| PPP1CA | dephosphorylation → down-regulates activity | MECOM | SIGNOR-273430 |
| PPP1CA | dephosphorylation → up-regulates activity | TRIM28 | SIGNOR-277075 |
| PPP1CA | dephosphorylation → up-regulates | IKZF1 | SIGNOR-174859 |
| PPP1CA | dephosphorylation → up-regulates activity | PREX2 | SIGNOR-277183 |
| PPP1CA | dephosphorylation → up-regulates activity | PREX1 | SIGNOR-277024 |
| PPP1CA | dephosphorylation → up-regulates activity | PREX1 | SIGNOR-277023 |
| PPP1CA | dephosphorylation → up-regulates activity | PREX1 | SIGNOR-277022 |
| PPP1CA | dephosphorylation → up-regulates activity | IFIH1 | SIGNOR-264577 |
| PPP1CA | dephosphorylation → up-regulates activity | WWTR1 | SIGNOR-277115 |
| PPP1CA | dephosphorylation → up-regulates activity | WWTR1 | SIGNOR-277116 |
| PPP1CA | dephosphorylation down-regulates | ERK1/2 | SIGNOR-269927 |
| PPP1CA | dephosphorylation down-regulates | AKT | SIGNOR-244436 |
| PPP1CA | dephosphorylation → down-regulates activity | AKT | SIGNOR-248559 |
| PPP1CA | dephosphorylation down-regulates | Gbeta | SIGNOR-269906 |
| PPP1CA | dephosphorylation → down-regulates activity | NMDA | SIGNOR-265061 |
| PPP1CA | dephosphorylation → down-regulates activity | AMPA | SIGNOR-265060 |
