Summary

Name PPP1CA
Full Name Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Synonyms PP-1A | PPP1A
Primary ID P62136
Links - -
Type protein
Relations 52
Pathways Dopaminergic Synapse, Noonan syndrome
Function Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation MECOM 0.2
Publications: 2
+ up-regulates img/direct-activation.png dephosphorylation PFN1 0.249
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation CAD 0.336
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation BRCA1 0.385
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.322
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CASP2 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation AXIN1 0.338
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation RAF1 0.274
Publications: 1 Organism: Homo Sapiens
Pathways:Noonan syndrome
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation MDM2 0.363
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.438
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT 0.438
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png dephosphorylation AHCYL1 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.334
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation DDX58 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation IFIH1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CASP9 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation CASP9 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation CCND3 0.248
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP1CA 0.405
Publications: 2 Organism: Homo Sapiens
Pathways:Dopaminergic Synapse
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP1CA 0.553
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP1CA 0.387
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP1CA 0.595
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.438
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation NOS3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPP1CA 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.457
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation Gbeta 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PPP1CA 0.571
Publications: 1 Organism: Homo Sapiens
Pathways:Noonan syndrome
+ down-regulates activity img/direct_inhibition.png dephosphorylation AMPA 0.501
Publications: 1 Organism: Homo Sapiens
Pathways:Dopaminergic Synapse
+ up-regulates img/direct-activation.png dephosphorylation IKZF1 0.284
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation NEK2 0.383
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT 0.438
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PPP1CA 0.791
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PPP1CA 0.405
Publications: 1
+ down-regulates activity img/direct_inhibition.png dephosphorylation SP1 0.27
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation ERK1/2 0.459
Publications: 1 Organism: Homo Sapiens
Pathways:Noonan syndrome
+ up-regulates img/direct-activation.png binding CDC25C 0.479
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PPP1CA 0.578
Publications: 1 Organism: Homo Sapiens
Pathways:Dopaminergic Synapse
+ down-regulates activity img/direct_inhibition.png dephosphorylation SP3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.459
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AURKA 0.447
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PPP1CA 0.558
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation NMDA 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
Pathways:Dopaminergic Synapse
+ down-regulates activity img/direct_inhibition.png binding PPP1CA 0.642
Publications: 1 Organism: In Vitro