| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | PPP1CA | Thr320 | NPGGRPItPPRNSAK | phosphorylation down-regulates activity | 12202491 | SIGNOR-151799 |
| CDK5 | PPP1CA | Thr320 | NPGGRPItPPRNSAK | phosphorylation down-regulates activity | 12202491 | SIGNOR-92269 |
| CDK5 | PPP1CA | Thr320 | NPGGRPItPPRNSAK | phosphorylation down-regulates activity | 17202132 | SIGNOR-151803 |
| CDK2 | PPP1CA | Thr320 | NPGGRPItPPRNSAK | phosphorylation down-regulates activity | 12202491 | SIGNOR-92265 |
| LMTK2 | PPP1CA | Thr320 | NPGGRPItPPRNSAK | phosphorylation down-regulates activity | 12393858 | SIGNOR-94631 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | PPP1CA PThr320 | phosphorylation down-regulates ⊣ | PPP1CA | 12202491 | SIGNOR-151799 |
| CDK5 | phosphorylation up-regulates → | PPP1CA PThr320 | phosphorylation down-regulates ⊣ | PPP1CA | 12202491 | SIGNOR-92269 |
| CDK5 | phosphorylation up-regulates → | PPP1CA PThr320 | phosphorylation down-regulates ⊣ | PPP1CA | 17202132 | SIGNOR-151803 |
| CDK2 | phosphorylation up-regulates → | PPP1CA PThr320 | phosphorylation down-regulates ⊣ | PPP1CA | 12202491 | SIGNOR-92265 |
| LMTK2 | phosphorylation up-regulates → | PPP1CA PThr320 | phosphorylation down-regulates ⊣ | PPP1CA | 12393858 | SIGNOR-94631 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → down-regulates activity | PPP1CA | SIGNOR-151799 |
| CDK5 | phosphorylation → down-regulates activity | PPP1CA | SIGNOR-92269 |
| CDK5 | phosphorylation → down-regulates activity | PPP1CA | SIGNOR-151803 |
| CDK2 | phosphorylation → down-regulates activity | PPP1CA | SIGNOR-92265 |
| LMTK2 | phosphorylation → down-regulates activity | PPP1CA | SIGNOR-94631 |
