Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
RPS6K	RPS6	Ser244 View in OncoXplorer	LRASTSKsESSQK	phosphorylation up-regulates	21233202	SIGNOR-252764
PAK2	RPS6	Ser235 View in OncoXplorer	IAKRRRLsSLRASTS	phosphorylation unknown	1985906	SIGNOR-250231
RPS6KA1	RPS6	Ser240 View in OncoXplorer	RLSSLRAsTSKSESS	phosphorylation up-regulates	21233202	SIGNOR-171243
PAK2	RPS6	Ser240 View in OncoXplorer	RLSSLRAsTSKSESS	phosphorylation unknown	1985906	SIGNOR-250233
PAK2	RPS6	Ser236 View in OncoXplorer	AKRRRLSsLRASTSK	phosphorylation unknown	1985906	SIGNOR-250232
RPS6KA1	RPS6	Ser235 View in OncoXplorer	IAKRRRLsSLRASTS	phosphorylation up-regulates	17360704	SIGNOR-153618
RPS6K	RPS6	Ser240 View in OncoXplorer	RLSSLRAsTSKSESS	phosphorylation up-regulates	21233202	SIGNOR-252765
RPS6KA1	RPS6	Ser236 View in OncoXplorer	AKRRRLSsLRASTSK	phosphorylation up-regulates	17360704	SIGNOR-153622
PAK2	RPS6	Ser242 View in OncoXplorer	SSLRASTsKSESSQK	phosphorylation unknown	1985906	SIGNOR-250234
RPS6KB1	RPS6	Ser236 View in OncoXplorer	AKRRRLSsLRASTSK	phosphorylation up-regulates activity	15809305	SIGNOR-135176
RPS6KA1	RPS6	Ser244 View in OncoXplorer	LRASTSKsESSQK	phosphorylation up-regulates	21233202	SIGNOR-171247
RPS6K	RPS6	Ser235 View in OncoXplorer	IAKRRRLsSLRASTS	phosphorylation up-regulates	17360704	SIGNOR-252813
RPS6KB1	RPS6	Ser235 View in OncoXplorer	IAKRRRLsSLRASTS	phosphorylation up-regulates activity	15809305	SIGNOR-135172
RPS6K	RPS6	Ser236 View in OncoXplorer	AKRRRLSsLRASTSK	phosphorylation up-regulates	17360704	SIGNOR-252812

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
RPS6K	phosphorylation up-regulates →	RPS6 PSer244	phosphorylation up-regulates →	RPS6	21233202	SIGNOR-252764
PAK2	phosphorylation up-regulates →	RPS6 PSer235	phosphorylation down-regulates ⊣	RPS6	1985906	SIGNOR-250231
RPS6KA1	phosphorylation up-regulates →	RPS6 PSer240	phosphorylation up-regulates →	RPS6	21233202	SIGNOR-171243
PAK2	phosphorylation up-regulates →	RPS6 PSer240	phosphorylation down-regulates ⊣	RPS6	1985906	SIGNOR-250233
PAK2	phosphorylation up-regulates →	RPS6 PSer236	phosphorylation down-regulates ⊣	RPS6	1985906	SIGNOR-250232
RPS6KA1	phosphorylation up-regulates →	RPS6 PSer235	phosphorylation up-regulates →	RPS6	17360704	SIGNOR-153618
RPS6K	phosphorylation up-regulates →	RPS6 PSer240	phosphorylation up-regulates →	RPS6	21233202	SIGNOR-252765
RPS6KA1	phosphorylation up-regulates →	RPS6 PSer236	phosphorylation up-regulates →	RPS6	17360704	SIGNOR-153622
PAK2	phosphorylation up-regulates →	RPS6 PSer242	phosphorylation down-regulates ⊣	RPS6	1985906	SIGNOR-250234
RPS6KB1	phosphorylation up-regulates →	RPS6 PSer236	phosphorylation up-regulates →	RPS6	15809305	SIGNOR-135176
RPS6KA1	phosphorylation up-regulates →	RPS6 PSer244	phosphorylation up-regulates →	RPS6	21233202	SIGNOR-171247
RPS6K	phosphorylation up-regulates →	RPS6 PSer235	phosphorylation up-regulates →	RPS6	17360704	SIGNOR-252813
RPS6KB1	phosphorylation up-regulates →	RPS6 PSer235	phosphorylation up-regulates →	RPS6	15809305	SIGNOR-135172
RPS6K	phosphorylation up-regulates →	RPS6 PSer236	phosphorylation up-regulates →	RPS6	17360704	SIGNOR-252812

Regulator	Mechanism/Effect	Target	SIGNOR-ID
RPS6K	phosphorylation → up-regulates	RPS6	SIGNOR-252764
PAK2	phosphorylation → unknown	RPS6	SIGNOR-250231
RPS6KA1	phosphorylation → up-regulates	RPS6	SIGNOR-171243
PAK2	phosphorylation → unknown	RPS6	SIGNOR-250233
PAK2	phosphorylation → unknown	RPS6	SIGNOR-250232
RPS6KA1	phosphorylation → up-regulates	RPS6	SIGNOR-153618
RPS6K	phosphorylation → up-regulates	RPS6	SIGNOR-252765
RPS6KA1	phosphorylation → up-regulates	RPS6	SIGNOR-153622
PAK2	phosphorylation → unknown	RPS6	SIGNOR-250234
RPS6KB1	phosphorylation → up-regulates activity	RPS6	SIGNOR-135176
RPS6KA1	phosphorylation → up-regulates	RPS6	SIGNOR-171247
RPS6K	phosphorylation → up-regulates	RPS6	SIGNOR-252813
RPS6KB1	phosphorylation → up-regulates activity	RPS6	SIGNOR-135172
RPS6K	phosphorylation → up-regulates	RPS6	SIGNOR-252812