| + |
RPS6K | up-regulates 
phosphorylation
|
RPS6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252813 |
Ser235 |
IAKRRRLsSLRASTS |
Homo sapiens |
|
| pmid |
sentence |
| 17360704 |
We demonstrate that while ribosomal s6 kinase 1 (s6k1) phosphorylates rps6 at all sites, rsk exclusively phosphorylates rps6 at ser(235/236) in vitro and in vivo using an mtor-independent mechanism. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252812 |
Ser236 |
AKRRRLSsLRASTSK |
Homo sapiens |
|
| pmid |
sentence |
| 17360704 |
We demonstrate that while ribosomal s6 kinase 1 (s6k1) phosphorylates rps6 at all sites, rsk exclusively phosphorylates rps6 at ser(235/236) in vitro and in vivo using an mtor-independent mechanism. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252765 |
Ser240 |
RLSSLRAsTSKSESS |
Homo sapiens |
|
| pmid |
sentence |
| 21233202 |
In response to mitogenic stimuli, rps6 undergoes ordered c-terminal phosphorylation by p70 s6 kinases and p90 ribosomal s6 kinases on four conserved ser residues (ser-235, ser-236, ser-240, and ser-244) whose modification potentiates rps6 cap binding activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252764 |
Ser244 |
LRASTSKsESSQK |
Homo sapiens |
|
| pmid |
sentence |
| 21233202 |
In response to mitogenic stimuli, rps6 undergoes ordered c-terminal phosphorylation by p70 s6 kinases and p90 ribosomal s6 kinases on four conserved ser residues (ser-235, ser-236, ser-240, and ser-244) whose modification potentiates rps6 cap binding activity |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
RPS6KB1 | up-regulates activity
phosphorylation
|
RPS6 |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135172 |
Ser235 |
IAKRRRLsSLRASTS |
Mus musculus |
|
| pmid |
sentence |
| 15809305 |
A knockin mouse carrying mutations at all phosphorylation sites in the primary s6k substrate, ribosomal protein s6 (rps6), has provided insight into the physiological role of this protein phosphorylation event. Of the many known substrates of s6k1, it is rps6 that has been shown to be directly involved, via its phosphorylation, in controlling cell size. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135176 |
Ser236 |
AKRRRLSsLRASTSK |
Mus musculus |
|
| pmid |
sentence |
| 15809305 |
A knockin mouse carrying mutations at all phosphorylation sites in the primary s6k substrate, ribosomal protein s6 (rps6), has provided insight into the physiological role of this protein phosphorylation event. Of the many known substrates of s6k1, it is rps6 that has been shown to be directly involved, via its phosphorylation, in controlling cell size. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | MTOR Signaling |
| + |
RPS6KA1 | up-regulates
phosphorylation
|
RPS6 |
0.575 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153618 |
Ser235 |
IAKRRRLsSLRASTS |
Homo sapiens |
|
| pmid |
sentence |
| 17360704 |
We demonstrate that while ribosomal s6 kinase 1 (s6k1) phosphorylates rps6 at all sites, rsk exclusively phosphorylates rps6 at ser(235/236) in vitro and in vivo using an mtor-independent mechanism. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153622 |
Ser236 |
AKRRRLSsLRASTSK |
Homo sapiens |
|
| pmid |
sentence |
| 17360704 |
We demonstrate that while ribosomal s6 kinase 1 (s6k1) phosphorylates rps6 at all sites, rsk exclusively phosphorylates rps6 at ser(235/236) in vitro and in vivo using an mtor-independent mechanism. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171243 |
Ser240 |
RLSSLRAsTSKSESS |
Homo sapiens |
|
| pmid |
sentence |
| 21233202 |
In response to mitogenic stimuli, rps6 undergoes ordered c-terminal phosphorylation by p70 s6 kinases and p90 ribosomal s6 kinases on four conserved ser residues (ser-235, ser-236, ser-240, and ser-244) whose modification potentiates rps6 cap binding activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171247 |
Ser244 |
LRASTSKsESSQK |
Homo sapiens |
|
| pmid |
sentence |
| 21233202 |
In response to mitogenic stimuli, rps6 undergoes ordered c-terminal phosphorylation by p70 s6 kinases and p90 ribosomal s6 kinases on four conserved ser residues (ser-235, ser-236, ser-240, and ser-244) whose modification potentiates rps6 cap binding activity |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | MTOR Signaling |
| + |
PAK2 |
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4.0
RPS6
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