| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | RPS6 | Ser236 | AKRRRLSsLRASTSK | phosphorylation up-regulates | 17360704 | SIGNOR-252812 |
| PAK2 | RPS6 | Ser236 | AKRRRLSsLRASTSK | phosphorylation unknown | 1985906 | SIGNOR-250232 |
| RPS6KA1 | RPS6 | Ser236 | AKRRRLSsLRASTSK | phosphorylation up-regulates | 17360704 | SIGNOR-153622 |
| RPS6KB1 | RPS6 | Ser236 | AKRRRLSsLRASTSK | phosphorylation up-regulates activity | 15809305 | SIGNOR-135176 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | phosphorylation up-regulates → | RPS6 PSer236 | phosphorylation up-regulates → | RPS6 | 17360704 | SIGNOR-252812 |
| PAK2 | phosphorylation up-regulates → | RPS6 PSer236 | phosphorylation down-regulates ⊣ | RPS6 | 1985906 | SIGNOR-250232 |
| RPS6KA1 | phosphorylation up-regulates → | RPS6 PSer236 | phosphorylation up-regulates → | RPS6 | 17360704 | SIGNOR-153622 |
| RPS6KB1 | phosphorylation up-regulates → | RPS6 PSer236 | phosphorylation up-regulates → | RPS6 | 15809305 | SIGNOR-135176 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6K | phosphorylation → up-regulates | RPS6 | SIGNOR-252812 |
| PAK2 | phosphorylation → unknown | RPS6 | SIGNOR-250232 |
| RPS6KA1 | phosphorylation → up-regulates | RPS6 | SIGNOR-153622 |
| RPS6KB1 | phosphorylation → up-regulates activity | RPS6 | SIGNOR-135176 |
