| Name | GRB2 |
| ID | P62993 |
| Role | substrate |
| Enzymatic Domains |
SH3 1 1-58 PROSITE-ProRule
SH2 60-152 PROSITE-ProRule
SH3 2 156-215 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BCR-ABL | GRB2 | Tyr37 | EECDQNWyKAELNGK | phosphorylation down-regulates activity | 20554525 | SIGNOR-246289 |
| BCR-ABL | GRB2 | Tyr52 | DGFIPKNyIEMKPHP | phosphorylation down-regulates activity | 20554525 | SIGNOR-246293 |
| PTPN11 | GRB2 | Tyr209 | TGMFPRNyVTPVNRN | dephosphorylation up-regulates activity | 23420874 | SIGNOR-276995 |
| ALK | GRB2 | Tyr160 | QVPQQPTyVQALFDF | phosphorylation unknown | 20554525 | SIGNOR-247142 |
| BCR-ABL | GRB2 | Tyr160 | QVPQQPTyVQALFDF | phosphorylation unknown | 20554525 | SIGNOR-247146 |
| SRC | GRB2 | Tyr160 | QVPQQPTyVQALFDF | phosphorylation unknown | 20554525 | SIGNOR-247138 |
| BCR-ABL | GRB2 | Tyr209 | TGMFPRNyVTPVNRN | phosphorylation down-regulates activity | 20554525 | SIGNOR-246281 |
| EGFR | GRB2 | Tyr209 | TGMFPRNyVTPVNRN | phosphorylation unknown | 11726515 | SIGNOR-235738 |
| BCR-ABL | GRB2 | Tyr7 | yDFKATAD | phosphorylation down-regulates activity | 20554525 | SIGNOR-246285 |
| FGFR2 | GRB2 | – | phosphorylation up-regulates | 22726438 | SIGNOR-197980 | |
| BCR-ABL | GRB2 | Tyr209 | TGMFPRNyVTPVNRN | phosphorylation down-regulates | 11726515 | SIGNOR-112354 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr37 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-246289 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr52 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-246293 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GRB2 PTyr209 | dephosphorylation down-regulates ⊣ | GRB2 | 23420874 | SIGNOR-276995 |
| ALK | phosphorylation up-regulates → | GRB2 PTyr160 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-247142 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr160 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-247146 |
| SRC | phosphorylation up-regulates → | GRB2 PTyr160 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-247138 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr209 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-246281 |
| EGFR | phosphorylation up-regulates → | GRB2 PTyr209 | phosphorylation down-regulates ⊣ | GRB2 | 11726515 | SIGNOR-235738 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr7 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-246285 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr209 | phosphorylation down-regulates ⊣ | GRB2 | 11726515 | SIGNOR-112354 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BCR-ABL | phosphorylation → down-regulates activity | GRB2 | SIGNOR-246289 |
| BCR-ABL | phosphorylation → down-regulates activity | GRB2 | SIGNOR-246293 |
| PTPN11 | dephosphorylation → up-regulates activity | GRB2 | SIGNOR-276995 |
| ALK | phosphorylation → unknown | GRB2 | SIGNOR-247142 |
| BCR-ABL | phosphorylation → unknown | GRB2 | SIGNOR-247146 |
| SRC | phosphorylation → unknown | GRB2 | SIGNOR-247138 |
| BCR-ABL | phosphorylation → down-regulates activity | GRB2 | SIGNOR-246281 |
| EGFR | phosphorylation → unknown | GRB2 | SIGNOR-235738 |
| BCR-ABL | phosphorylation → down-regulates activity | GRB2 | SIGNOR-246285 |
| FGFR2 | phosphorylation → up-regulates | GRB2 | SIGNOR-197980 |
| BCR-ABL | phosphorylation down-regulates | GRB2 | SIGNOR-112354 |