Summary

Name GRB2
Full Name Growth factor receptor-bound protein 2
Synonyms Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2 | ASH
Primary ID P62993
Links - -
Type protein
Relations 58
Pathways Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, B-cell activation, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Luminal Breast Cancer, Mitochondrial dynamics in T cell exhaustion, Malignant Melanoma, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, Thyroid cancer, T cell activation, VEGF Signaling
Function Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation GRB2 0.481
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRB2 0.622
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, IL6 Signaling, Integrin Signaling, Rhabdomyosarcoma
+ img/unknown.png phosphorylation GRB2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML
+ down-regulates activity img/direct_inhibition.png phosphorylation GRB2 0.2
Publications: 4 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML
+ down-regulates img/direct_inhibition.png phosphorylation GRB2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML
+ img/unknown.png phosphorylation GRB2 0.921
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ up-regulates img/direct-activation.png binding GRB2 0.831
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRB2 0.763
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2 0.796
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Insulin Signaling, Luminal Breast Cancer
+ up-regulates activity img/direct-activation.png binding GRB2 0.483
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png relocalization SOS1 0.91
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, SARS-CoV MAPK PERTURBATION, Thyroid cancer, T cell activation, VEGF Signaling
+ up-regulates img/direct-activation.png binding SOS2 0.875
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2 0.921
Publications: 3 Organism: In Vitro, Homo Sapiens, Mus Musculus
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ up-regulates activity img/direct-activation.png binding GRB2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:ErbB receptors in cancer, Non-small-cell lung cancer (NSCLC), RTKs in cancer
+ up-regulates activity img/direct-activation.png binding GRB2 0.585
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, EGFR Signaling
+ up-regulates img/direct-activation.png relocalization CBL 0.9
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, Glioblastoma Multiforme
+ up-regulates img/direct-activation.png relocalization GRB2 0.843
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma
+ up-regulates img/direct-activation.png binding ABL1 0.556
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRB2 0.822
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRB2 0.965
Publications: 4 Organism: Homo Sapiens, Mus Musculus, Sus Scrofa
Pathways:Acute Myeloid Leukemia, EGFR Signaling, IL6 Signaling, Noonan syndrome, Thyroid cancer
+ up-regulates activity img/direct-activation.png binding INPP5D 0.559
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, B-cell activation
+ down-regulates img/indirect_inhibition.png KIT 0.632
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML, Malignant Melanoma
+ up-regulates activity img/direct-activation.png binding GRB2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling, PI3K/AKT Signaling, RTKs in cancer
+ up-regulates activity img/direct-activation.png binding GRB2 0.68
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor, Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png binding GRB2 0.692
Publications: 1
Pathways:Integrin Signaling, VEGF Signaling
+ up-regulates img/direct-activation.png binding GRB2 0.664
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRB2 0.69
Publications: 2 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/indirect-activation.png GRB2 0.7
Publications: 1
Pathways:Inhibition of Apoptosis
+ up-regulates img/direct-activation.png binding GRB2 0.666
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization GRB2 0.67
Publications: 1 Organism: Sus Scrofa Domesticus
Pathways:VEGF Signaling
+ up-regulates activity img/direct-activation.png binding GRB2 0.2
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML
+ up-regulates img/direct-activation.png binding GRB2 0.797
Publications: 2 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation
+ up-regulates activity img/direct-activation.png binding GRB2 0.576
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png binding GRB2 0.721
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, EGFR Signaling, Noonan syndrome
+ up-regulates img/direct-activation.png binding GAB1 0.867
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, Hepatocellular Tumor, Noonan syndrome, PI3K/AKT Signaling, Rhabdomyosarcoma
+ up-regulates img/direct-activation.png binding MAP4K1 0.467
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates img/direct-activation.png relocalization GRB2 0.809
Publications: 2 Organism: Homo Sapiens
Pathways:Rett syndrome
+ up-regulates activity img/direct-activation.png binding GRB2 0.588
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML
+ up-regulates img/direct-activation.png binding GAB2 0.907
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2 0.632
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML, Malignant Melanoma
+ up-regulates activity img/direct-activation.png binding GRB2 0.794
Publications: 1 Organism: Rattus Norvegicus
Pathways:Luminal Breast Cancer
+ down-regulates activity img/direct_inhibition.png binding GRB2 0.2
Publications: 1 Organism: Homo Sapiens