Summary

Name GRB2
Full Name Growth factor receptor-bound protein 2
Synonyms Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2 | ASH
Primary ID P62993
Links - -
Type protein
Relations 59
Pathways Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, B-cell activation, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, Glioblastoma Multiforme, GPCR_CRC, GPCR_HCC, Hepatocellular Tumor, IL6 Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Luminal Breast Cancer, Macropinocytosis , Mitochondrial dynamics in T cell exhaustion, Malignant Melanoma, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, Thyroid cancer, T cell activation, VEGF Signaling
Function Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation GRB2 0.468
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRB2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML
+ img/unknown.png phosphorylation GRB2 0.641
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, IL6 Signaling, Integrin Signaling, Rhabdomyosarcoma
+ down-regulates activity img/direct_inhibition.png phosphorylation GRB2 0.2
Publications: 4 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML
+ up-regulates activity img/direct-activation.png dephosphorylation, binding GRB2 0.736
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, EGFR Signaling, Noonan syndrome
+ down-regulates img/direct_inhibition.png phosphorylation GRB2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML
+ img/unknown.png phosphorylation GRB2 0.924
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ down-regulates img/indirect_inhibition.png KIT 0.648
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML, Malignant Melanoma
+ up-regulates activity img/direct-activation.png binding GRB2 0.694
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor, Rhabdomyosarcoma
+ up-regulates img/direct-activation.png binding GRB2 0.804
Publications: 2 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation
+ up-regulates activity img/direct-activation.png relocalization SOS1 0.913
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, COVID-19 Causal Network, Colorectal Carcinoma, EGFR Signaling, ErbB receptors in cancer, Glioblastoma Multiforme, Hepatocellular Tumor, IL6 Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, Rett syndrome, Rhabdomyosarcoma, RTKs in cancer, SARS-CoV MAPK PERTURBATION, Thyroid cancer, T cell activation, VEGF Signaling
+ up-regulates activity img/direct-activation.png binding GRB2 0.648
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML, Malignant Melanoma
+ up-regulates activity img/direct-activation.png binding GRB2 0.2
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML
+ up-regulates img/direct-activation.png binding GRB2 0.701
Publications: 2 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png binding ABL1 0.578
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2 0.924
Publications: 3 Organism: In Vitro, Mus Musculus, Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ down-regulates activity img/direct_inhibition.png binding GRB2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRB2 0.966
Publications: 4 Organism: Homo Sapiens, Sus Scrofa, Mus Musculus
Pathways:Acute Myeloid Leukemia, EGFR Signaling, IL6 Signaling, Noonan syndrome, Thyroid cancer
+ up-regulates img/direct-activation.png relocalization GRB2 0.819
Publications: 2 Organism: Homo Sapiens
Pathways:Rett syndrome
+ up-regulates activity img/direct-activation.png binding GRB2 0.556
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates img/direct-activation.png binding GRB2 0.83
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2 0.464
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding GRB2 0.678
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png GRB2 0.7
Publications: 1
Pathways:Inhibition of Apoptosis
+ up-regulates activity img/direct-activation.png binding INPP5D 0.581
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, B-cell activation
+ up-regulates img/direct-activation.png binding SOS2 0.88
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization GRB2 0.85
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma
+ up-regulates img/direct-activation.png binding GRB2 0.685
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GAB2 0.912
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:ErbB receptors in cancer, Non-small-cell lung cancer (NSCLC), RTKs in cancer
+ up-regulates activity img/direct-activation.png binding GRB2 0.57
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, EGFR Signaling
+ up-regulates activity img/direct-activation.png binding GRB2 0.603
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML
+ up-regulates img/direct-activation.png binding GRB2 0.839
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2 0.803
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Insulin Signaling, Luminal Breast Cancer
+ up-regulates img/direct-activation.png phosphorylation GRB2 0.772
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization CBL 0.905
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, Glioblastoma Multiforme
+ up-regulates activity img/direct-activation.png relocalization GRB2 0.684
Publications: 1 Organism: Sus Scrofa Domesticus
Pathways:VEGF Signaling
+ up-regulates img/direct-activation.png binding GAB1 0.873
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, Hepatocellular Tumor, Noonan syndrome, PI3K/AKT Signaling, Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png binding GRB2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling, PI3K/AKT Signaling, RTKs in cancer
+ up-regulates activity img/direct-activation.png binding GRB2 0.802
Publications: 1 Organism: Rattus Norvegicus
Pathways:Luminal Breast Cancer
+ up-regulates img/direct-activation.png binding MAP4K1 0.455
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png binding GRB2 0.705
Publications: 1
Pathways:Integrin Signaling, VEGF Signaling