| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ALK | GRB2 | Tyr160 | QVPQQPTyVQALFDF | phosphorylation unknown | 20554525 | SIGNOR-247142 |
| BCR-ABL | GRB2 | Tyr160 | QVPQQPTyVQALFDF | phosphorylation unknown | 20554525 | SIGNOR-247146 |
| SRC | GRB2 | Tyr160 | QVPQQPTyVQALFDF | phosphorylation unknown | 20554525 | SIGNOR-247138 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ALK | phosphorylation up-regulates → | GRB2 PTyr160 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-247142 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr160 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-247146 |
| SRC | phosphorylation up-regulates → | GRB2 PTyr160 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-247138 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ALK | phosphorylation → unknown | GRB2 | SIGNOR-247142 |
| BCR-ABL | phosphorylation → unknown | GRB2 | SIGNOR-247146 |
| SRC | phosphorylation → unknown | GRB2 | SIGNOR-247138 |
