| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | GRB2 | Tyr209 | TGMFPRNyVTPVNRN | dephosphorylation up-regulates activity | 23420874 | SIGNOR-276995 |
| BCR-ABL | GRB2 | Tyr209 | TGMFPRNyVTPVNRN | phosphorylation down-regulates activity | 20554525 | SIGNOR-246281 |
| EGFR | GRB2 | Tyr209 | TGMFPRNyVTPVNRN | phosphorylation unknown | 11726515 | SIGNOR-235738 |
| BCR-ABL | GRB2 | Tyr209 | TGMFPRNyVTPVNRN | phosphorylation down-regulates | 11726515 | SIGNOR-112354 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | dephosphorylation down-regulates ⊣ | GRB2 PTyr209 | dephosphorylation down-regulates ⊣ | GRB2 | 23420874 | SIGNOR-276995 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr209 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-246281 |
| EGFR | phosphorylation up-regulates → | GRB2 PTyr209 | phosphorylation down-regulates ⊣ | GRB2 | 11726515 | SIGNOR-235738 |
| BCR-ABL | phosphorylation up-regulates → | GRB2 PTyr209 | phosphorylation down-regulates ⊣ | GRB2 | 11726515 | SIGNOR-112354 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN11 | dephosphorylation → up-regulates activity | GRB2 | SIGNOR-276995 |
| BCR-ABL | phosphorylation → down-regulates activity | GRB2 | SIGNOR-246281 |
| EGFR | phosphorylation → unknown | GRB2 | SIGNOR-235738 |
| BCR-ABL | phosphorylation down-regulates | GRB2 | SIGNOR-112354 |
