| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2 | RAC1 | – | phosphorylation up-regulates activity | 22163037 | SIGNOR-279652 | |
| AKT1 | RAC1 | Ser71 | YDRLRPLsYPQTDVF | phosphorylation down-regulates activity | 10617634 | SIGNOR-252576 |
| LRRK1 | RAC1 | – | phosphorylation up-regulates activity | 27600824 | SIGNOR-279626 | |
| SRC | RAC1 | – | phosphorylation up-regulates | 17991704 | SIGNOR-158954 | |
| SRC | RAC1 | Tyr64 | DTAGQEDyDRLRPLS | phosphorylation up-regulates activity | 30544910 | SIGNOR-280132 |
| AKT | RAC1 | Ser71 | YDRLRPLsYPQTDVF | phosphorylation down-regulates activity | 10617634 | SIGNOR-248036 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | RAC1 PSer71 | phosphorylation down-regulates ⊣ | RAC1 | 10617634 | SIGNOR-252576 |
| SRC | phosphorylation up-regulates → | RAC1 PTyr64 | phosphorylation up-regulates → | RAC1 | 30544910 | SIGNOR-280132 |
| AKT | phosphorylation up-regulates → | RAC1 PSer71 | phosphorylation down-regulates ⊣ | RAC1 | 10617634 | SIGNOR-248036 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTK2 | phosphorylation → up-regulates activity | RAC1 | SIGNOR-279652 |
| AKT1 | phosphorylation → down-regulates activity | RAC1 | SIGNOR-252576 |
| LRRK1 | phosphorylation → up-regulates activity | RAC1 | SIGNOR-279626 |
| SRC | phosphorylation → up-regulates | RAC1 | SIGNOR-158954 |
| SRC | phosphorylation → up-regulates activity | RAC1 | SIGNOR-280132 |
| AKT | phosphorylation → down-regulates activity | RAC1 | SIGNOR-248036 |
