Summary

Name RAC1
Full Name Ras-related C3 botulinum toxin substrate 1
Synonyms Cell migration-inducing gene 5 protein, Ras-like protein TC25, p21-Rac1 | TC25
Primary ID P63000
Links - -
Type protein
Relations 112
Pathways Axon guidance, Acute Myeloid Leukemia, FLT3-ITD in AML, Macropinocytosis , WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
Function Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles (PubMed:1643658, PubMed:28886345). Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (PubMed:9121475). In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (PubMed:1643658). In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In neurons, is involved in dendritic spine formation and synaptic plasticity (By similarity). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png ubiquitination RAC1 0.368
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAC1 0.724
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAC1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT/FLT3
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.467
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RAC1 0.263
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png binding RAC1 0.467
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png relocalization RAC1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.499
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.588
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.584
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.439
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.581
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAC1 0.582
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.584
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.399
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.691
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.526
Publications: 1
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.52
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.527
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.432
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAPK8 0.658
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding GIT1 0.655
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.399
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation RAC1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.442
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor, catalytic activity RAC1 0.607
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.663
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PAK2 0.749
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding Phagocyte NADPH oxidase complex 0.606
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RAC1 0.408
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.588
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK9 0.521
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.582
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.495
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RAC1 0.568
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAC1 0.5
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.764
Publications: 2 Organism: Homo Sapiens, Drosophila Melanogaster
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.544
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RAC1 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT/FLT3
+ up-regulates img/direct-activation.png binding RAC1 0.482
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png lipidation RAC1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png relocalization USP6 0.339
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.604
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK8 0.658
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.718
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAC1 0.277
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png RAC1 0.274
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RAC1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RAC1 0.636
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization RAC1 0.407
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.432
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RAC1 0.451
Publications: 1
+ up-regulates img/indirect-activation.png RAC1 0.75
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.587
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png gtpase-activating protein RAC1 0.589
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.539
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination RAC1 0.368
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.76
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.564
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RAC1 0.714
Publications: 1
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.664
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png guanine nucleotide exchange factor RAC1 0.811
Publications: 1 Organism: Rattus Norvegicus
Pathways:Axon guidance
+ up-regulates activity img/indirect-activation.png MAPK8 0.658
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.433
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PAK1 0.789
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding PAK 0.789
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.638
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.441
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.381
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3
+ up-regulates img/indirect-activation.png RAC1 0.547
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT/FLT3
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.586
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.558
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ROCK1 0.405
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding RAC1 0.583
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.564
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.655
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.298
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.477
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RAC1 0.537
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RAC1 0.582
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.501
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor RAC1 0.62
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding BAIAP2 0.739
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates img/indirect-activation.png RAC1 0.623
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png RAC1 0.281
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor RAC1 0.76
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK14 0.534
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.622
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ALS2 0.531
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.564
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png RAC1 0.564
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RAC1 0.75
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.723
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.734
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation RAC1 0.613
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.427
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.579
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BAIAP2 0.739
Publications: 1 Organism: Mus Musculus
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.599
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RAC1 0.465
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.452
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.75
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RAC1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.543
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png Proliferation 0.7
Publications: 1
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3
+ up-regulates activity img/direct-activation.png WAVE complex 0.623
Publications: 1 Organism: Homo Sapiens