| + |
AKT | down-regulates activity 
phosphorylation
|
RAC1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251486 |
Ser71 |
YDRLRPLsYPQTDVF |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 10617634 |
Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248036 |
Ser71 |
YDRLRPLsYPQTDVF |
Homo sapiens |
SK-MEL-2 Cell |
| pmid |
sentence |
| 10617634 |
The results suggest that Akt kinase of the phosphoinositide 3-kinase signal transduction pathway phosphorylates serine 71 of Rac1 as one of its authentic substrates and modulates the Rac1 signal transduction pathway through phosphorylation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AKT1 | down-regulates activity
phosphorylation
|
RAC1 |
0.42 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252556 |
Ser71 |
YDRLRPLsYPQTDVF |
Homo sapiens |
SK-MEL-2 Cell |
| pmid |
sentence |
| 10617634 |
The results suggest that Akt kinase of the phosphoinositide 3-kinase signal transduction pathway phosphorylates serine 71 of Rac1 as one of its authentic substrates and modulates the Rac1 signal transduction pathway through phosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252576 |
Ser71 |
YDRLRPLsYPQTDVF |
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 10617634 |
Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
TGFBR1 | up-regulates activity 
unknown
|
RAC1 |
0.20 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227496 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19726546 |
Thus, TGF-_1 rapidly stimulates activity of both RhoA and Rac1 and this activation requires ALK5/T_RI kinase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HACE1 | down-regulates quantity by destabilization
ubiquitination
|
RAC1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255538 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22036506 |
The CNF1 toxin of pathogenic Escherichia coli addresses Rac1 to ubiquitin-proteasome system (UPS). We report the essential role of the tumor suppressor HACE1, a HECT-domain containing E3 ubiquitin-ligase, in the targeting of Rac1 to UPS. HACE1 binds preferentially GTP-bound Rac1 and catalyzes its polyubiquitylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAC1 | up-regulates activity
binding
|
PAK1 |
0.79 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248236 |
|
|
Mus musculus |
Brain |
| pmid |
sentence |
| 8107774 |
A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FZD7 | up-regulates activity 
unknown
|
RAC1 |
0.23 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255647 |
|
|
|
|
| pmid |
sentence |
| 23290138 |
We observed that overexpression of Fzd7 or stimulation with FN resulted in increased levels of active Rac1 in primary myoblasts |
|
| Publications: |
1 |
| + |
RAC1 | up-regulates activity
unknown
|
Proliferation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255648 |
|
|
|
|
| pmid |
sentence |
| 23290138 |
This result strongly supports the assertion that Wnt7a and FN stimulate PCP signaling to drive the symmetric expansion of satellite stem cells during regenerative myogenesis. |
|
| Publications: |
1 |
| Pathways: | WNT Signaling |
| + |
RAC1 | up-regulates activity
binding
|
PAK2 |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248250 |
|
|
Mus musculus |
Brain |
| pmid |
sentence |
| 8107774 |
A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RAC1 | up-regulates activity
binding
|
PAK |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248256 |
|
|
Mus musculus |
Brain |
| pmid |
sentence |
| 8107774 |
A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RAC1 | up-regulates activity
binding
|
MAPK8 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195414 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22252525 |
The mechanism by which pak1 induced cancer growth might involve activation of jnk in the non-canonical wnt pathway, frizzled uses galfaq or galfai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat, and frizzled also signals through the small gtpases rho and rac to c-jun n-terminal kinase (jnk), which activates the ap1 transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
RAC1 | up-regulates
binding
|
MAPK8 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152808 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
The mechanism by which pak1 induced cancer growth might involve activation of jnk in the non-canonical wnt pathway, frizzled uses galfaq or galfai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat, and frizzled also signals through the small gtpases rho and rac to c-jun n-terminal kinase (jnk), which activates the ap1 transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
RAC1 | up-regulates activity
unknown
|
MAPK8 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Planar cell polarity (pcp) signalling triggers activation of the small gtpases rhoa and rac1, which in turn activate rho kinase (rock) and jun-n-terminal kinase (jnk), respectively, leading to actin polymerization and microtubule stabilization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
DVL1 | up-regulates activity
unknown
|
RAC1 |
0.22 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199384 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
In pcp , dvl binds to proteins such as pkc, atypical pkc (apkc), dvl associated activator of morphogenesis 1 (daam1), dvl-associating protein with a high frequency of leu residues (daple) and partitioning defective 6 (par6), which are important for the regulation of small gtpases such as rho and rac and, consequently, the cytoskeleton and cell polarity58. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
DVL1 | up-regulates activity
binding
|
RAC1 |
0.22 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185274 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19365405 |
B-catenin-independent wnt signaling can activate rho family gtpases through at least two mechanisms: (1) direct activation of rac1 by dvl;and (2) activation of rhoa via dvl-associated activator of morphogenesis-1 (daam1), possibly through the weak-similarity guaninenucleotide exchange factor (wgef)1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
DVL3 | up-regulates
binding
|
RAC1 |
0.23 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97409 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12533515 |
Wnt/fz activation of rac and rho is inhibited by rac-n17 and rho-n19, respectively (figs. _(figs.1d,1d, _d,5c,d;5c,d;habas et al. 2001), and requires different dvl domains wnt signaling induces complex formation between dvl and rac. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VAV2 | up-regulates
guanine nucleotide exchange factor
|
RAC1 |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81645 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10982832 |
Vav2 activates rac1 / vav2 is an exchange factor for rho family gtpases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLCG1 | up-regulates
unknown
|
RAC1 |
0.21 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155747 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17562871 |
We propose that the association of plcgamma1 with complexes containing git1 and beta-pix is essential for its role in integrin-mediated cell spreading and motility. As a component of this complex, plcgamma1 is also involved in the activation of cdc42 and rac1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAP1GDS1 | up-regulates
binding
|
RAC1 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171418 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21242305 |
Smggds has been previously shown to activate a wide variety of small gtpases, including the ras family members rap1a, rap1b, and k-ras, as well as the rho family members cdc42, rac1, rac2, rhoa, and rhob |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AC1NUST0 | up-regulates
binding
|
RAC1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178632 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18480413 |
The c-terminal polybasic motif of rac1 is responsible for direct interaction with pa, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PARD6A | up-regulates
unknown
|
RAC1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199530 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
In pcp , dvl binds to proteins such as pkc, atypical pkc (apkc), dvl?associated Activator of morphogenesis 1 (daam1), dvl-associating protein with a high frequency of leu residues (daple) and partitioning defective 6 (par6), which are important for the regulation of small gtpases such as rho and rac and, consequently, the cytoskeleton and cell polarity58. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TIAM1 | up-regulates
unknown
|
RAC1 |
0.70 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167073 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20654717 |
This smo-tiam1 complex dissociates upon shh-mediated activation of smo, thus allowing tiam1 to activate rac1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
DAAM1 | up-regulates activity
unknown
|
RAC1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199381 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
In pcp, dvl binds to proteins such as pkc, atypical pkc (apkc), dvl?associated Activator of morphogenesis 1 (daam1), dvl-associating protein with a high frequency of leu residues (daple) and partitioning defective 6 (par6), which are important for the regulation of small gtpases such as rho and rac and, consequently, the cytoskeleton and cell polarity58. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
RAC1 | up-regulates
binding
|
BAIAP2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-85302 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11130076 |
Here we demonstrate that irsp53, a substrate for insulin receptor with unknown function, is the 'missing link' between rac and wave. Activated rac binds to the amino terminus of irsp53, and carboxy-terminal src-homology-3 domain of irsp53 binds to wave to form a trimolecular complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates
phosphorylation
|
RAC1 |
0.22 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158954 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17991704 |
N attractive hypothesis consistent with our present data is that the gef responsible for rac activation in mce cells may be activated by src family kinase tyrosine phosphorylationour results present a novel mechanism by which the pi3k and src signaling cascades cooperate to activate rac and promote intestinal epithelial cell migration downstream of egfr. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MTSS1 | up-regulates
binding
|
RAC1 |
0.13 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141573 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16280553 |
Mim-b binds and activates rac via its irsp53/mim domain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TIAM1 | up-regulates
binding
|
RAC1 |
0.70 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94691 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12393875 |
Lpa-induced rac activation requires tiam1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAC1 | up-regulates
relocalization
|
USP6 |
0.08 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98938 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12612085 |
In quiescent cells, tre17 is localized to intracellular filamentous and punctate structures in the cytoplasm, folded in an inactive conformation. Upon growth factor addition, cdc42 and rac1 become activated and recruit tre17 to the plasma membrane. Stable membrane localization of tre17 also requires polymerized actin. This recruitment process leads to a conformational change in tre17, such that the n-terminal portion of the molecule further stimulates the accumulation of cortical actin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARHGEF7 | up-regulates
unknown
|
RAC1 |
0.54 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155744 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17562871 |
We propose that the association of plcgamma1 with complexes containing git1 and beta-pix is essential for its role in integrin-mediated cell spreading and motility. As a component of this complex, plcgamma1 is also involved in the activation of cdc42 and rac1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3CA | up-regulates
unknown
|
RAC1 |
0.20 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175238 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21779497 |
Pi3k can also activate rac, and this activation is involved in cytoskeleton reorganization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAC1 | up-regulates
binding
|
MAPK9 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178265 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18423204 |
We show that rac1 activates jnk2 that in turn phosphorylates beta-catenin on critical residues and controls its nuclear translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNND1 | up-regulates
binding
|
RAC1 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198938 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22946057 |
We demonstrate that p120-catenin participates in the stimulation of rac1 activity, binding directly to this protein. In addition we show that vav2 also binds to p120-catenin and is required for rac1 activation and for beta-catenin translocation to the nucleus.Vav2 And rac1 association with p120-catenin was modulated by phosphorylation of this protein, which was stimulated upon serine/threonine phosphorylation by ck1 and inhibited by tyrosine phosphorylation by src or fyn |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRGAP3 | down-regulates 
unknown
|
RAC1 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95918 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12447388 |
Wrp binds directly to wave-1 through its src homology domain 3 and specifically inhibits rac function in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAC1 | up-regulates
unknown
|
MAPK14 |
0.22 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174602 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21712438 |
Hypertonicity activates p38 via a rac1-osm-mekk3-mkk3-p38 pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARHGEF25 | up-regulates
guanine nucleotide exchange factor
|
RAC1 |
0.08 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236882 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 16314529 |
Exogenous expression of geft promotes myogenesis ofc2c12 cells via activation of rhoa, rac1, and cdc42 and their downstream effector proteins, while a dominant negative mutant of geft inhibits this process. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SDC4 | up-regulates activity
binding
|
RAC1 |
0.17 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255849 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 23290138 |
Rac1 is associated with Sdc4 and is activated by FN binding […] We observed that over-expression of Fzd7, or stimulation with FN resulted in increased levels of active Rac1 in primary myoblasts |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
PI3K | up-regulates
unknown
|
RAC1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252707 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21779497 |
Pi3k can also activate rac, and this activation is involved in cytoskeleton reorganization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH4 | up-regulates activity
unknown
|
RAC1 |
0.08 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253103 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 18701479 |
Together, these data suggest that R-cadherin expression inhibits myogenesis and induces myoblast transformation through Rac1 activation. Therefore, the properties of R-cadherin make it an attractive target for therapeutic intervention in RMS. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
RAC1
- 
- 