Summary

Name RAC1
Full Name Ras-related C3 botulinum toxin substrate 1
Synonyms Cell migration-inducing gene 5 protein, Ras-like protein TC25, p21-Rac1 | TC25
Primary ID P63000
Links - -
Type protein
Relations 106
Pathways Axon guidance, Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
Function Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles (PubMed:1643658, PubMed:28886345). Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (PubMed:9121475). In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (PubMed:1643658). In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In neurons, is involved in dendritic spine formation and synaptic plasticity (By similarity). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation RAC1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT/FLT3
+ down-regulates activity img/direct_inhibition.png phosphorylation RAC1 0.713
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.412
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation RAC1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.722
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.565
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png Proliferation 0.7
Publications: 1
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.566
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RAC1 0.439
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.398
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.588
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PAK1 0.779
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding MAPK9 0.499
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.425
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RAC1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.502
Publications: 1
+ up-regulates img/indirect-activation.png RAC1 0.545
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RAC1 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT/FLT3
+ up-regulates img/direct-activation.png binding RAC1 0.739
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png lipidation RAC1 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.565
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png guanine nucleotide exchange factor RAC1 0.802
Publications: 1 Organism: Rattus Norvegicus
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.566
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.413
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.754
Publications: 2 Organism: Drosophila Melanogaster, Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.705
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BAIAP2 0.724
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates activity img/indirect-activation.png RAC1 0.426
Publications: 1
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.651
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ROCK1 0.416
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding RAC1 0.701
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination RAC1 0.374
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK8 0.643
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.415
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.739
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK14 0.513
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png RAC1 0.285
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization RAC1 0.379
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RAC1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.303
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RAC1 0.616
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.478
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.603
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RAC1 0.618
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.648
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.407
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization USP6 0.344
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png RAC1 0.279
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.563
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.544
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAC1 0.479
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.371
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.505
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.52
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.403
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PAK 0.779
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding PAK2 0.737
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.442
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.559
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.403
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BAIAP2 0.724
Publications: 1 Organism: Mus Musculus
Pathways:Axon guidance
+ up-regulates activity img/indirect-activation.png RAC1 0.561
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.641
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.517
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor, catalytic activity RAC1 0.59
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor RAC1 0.602
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png WAVE complex 0.606
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RAC1 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding RAC1 0.282
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.471
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.62
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.673
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.579
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor RAC1 0.75
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png RAC1 0.544
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.71
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.476
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.451
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.542
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAC1 0.561
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates img/indirect-activation.png RAC1 0.513
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.538
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.569
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.388
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.567
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MAPK8 0.643
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.557
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.371
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.75
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAC1 0.598
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates img/direct-activation.png binding RAC1 0.566
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.434
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAC1 0.441
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3
+ up-regulates activity img/direct-activation.png binding MAPK8 0.643
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates img/indirect-activation.png RAC1 0.739
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.541
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png gtpase-activating protein RAC1 0.57
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.495
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RAC1 0.522
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT/FLT3
+ up-regulates img/direct-activation.png binding RAC1 0.455
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.523
Publications: 1 Organism: Homo Sapiens