Summary

Name RAC1
Full Name Ras-related C3 botulinum toxin substrate 1
Synonyms Cell migration-inducing gene 5 protein, Ras-like protein TC25, p21-Rac1 | TC25
Primary ID P63000
Links - -
Type protein
Relations 39
Pathways WNT Signaling, WNT Signaling and Myogenesis
Function Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.; FUNCTION

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation RAC1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png unknown RAC1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding RAC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown Proliferation 0.31
Publications: 1
Pathways:WNT Signaling
+ up-regulates activity img/direct-activation.png binding PAK2 0.51
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor RAC1 0.31
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination RAC1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BAIAP2 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RAC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown RAC1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/indirect-activation.png unknown MAPK14 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png unknown RAC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RAC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAC1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates img/indirect-activation.png unknown RAC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RAC1 0.45
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor RAC1 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown RAC1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ROCK1
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding PAK1 0.57
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png unknown RAC1 0.14
Publications: 1
+ up-regulates activity img/direct-activation.png binding PAK 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding MAPK8 0.48
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding MAPK8 0.48
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/indirect-activation.png unknown RAC1 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/indirect-activation.png unknown MAPK8 0.48
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding RAC1 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding RAC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown RAC1 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown RAC1 0.45
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation RAC1 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization USP6 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown RAC1 0.51
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown RAC1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK9 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RAC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAC1 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png unknown RAC1 0.31
Publications: 1 Organism: Homo Sapiens