| Name | GNAI1 |
| ID | P63096 |
| Role | substrate |
| Enzymatic Domains |
G-alpha 32-354 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | GNAI1 | Tyr155 | LNDSAAYyLNDLDRI | phosphorylation up-regulates activity | 33139573 | SIGNOR-277226 |
| PDGFRB | GNAI1 | Tyr155 | LNDSAAYyLNDLDRI | phosphorylation up-regulates activity | 33139573 | SIGNOR-277232 |
| EGFR | GNAI1 | Tyr154 | QLNDSAAyYLNDLDR | phosphorylation up-regulates activity | 33139573 | SIGNOR-277227 |
| PDGFRB | GNAI1 | Tyr320 | RKDTKEIyTHFTCAT | phosphorylation up-regulates activity | 33139573 | SIGNOR-277234 |
| FLT1 | GNAI1 | Tyr320 | RKDTKEIyTHFTCAT | phosphorylation up-regulates activity | 33139573 | SIGNOR-277231 |
| EGFR | GNAI1 | Tyr320 | RKDTKEIyTHFTCAT | phosphorylation up-regulates activity | 33139573 | SIGNOR-277228 |
| FLT1 | GNAI1 | Tyr154 | QLNDSAAyYLNDLDR | phosphorylation up-regulates activity | 33139573 | SIGNOR-277230 |
| PDGFRB | GNAI1 | Tyr154 | QLNDSAAyYLNDLDR | phosphorylation up-regulates activity | 33139573 | SIGNOR-277233 |
| FLT1 | GNAI1 | Tyr155 | LNDSAAYyLNDLDRI | phosphorylation up-regulates activity | 33139573 | SIGNOR-277229 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | GNAI1 PTyr155 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277226 |
| PDGFRB | phosphorylation up-regulates → | GNAI1 PTyr155 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277232 |
| EGFR | phosphorylation up-regulates → | GNAI1 PTyr154 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277227 |
| PDGFRB | phosphorylation up-regulates → | GNAI1 PTyr320 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277234 |
| FLT1 | phosphorylation up-regulates → | GNAI1 PTyr320 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277231 |
| EGFR | phosphorylation up-regulates → | GNAI1 PTyr320 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277228 |
| FLT1 | phosphorylation up-regulates → | GNAI1 PTyr154 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277230 |
| PDGFRB | phosphorylation up-regulates → | GNAI1 PTyr154 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277233 |
| FLT1 | phosphorylation up-regulates → | GNAI1 PTyr155 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277229 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277226 |
| PDGFRB | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277232 |
| EGFR | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277227 |
| PDGFRB | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277234 |
| FLT1 | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277231 |
| EGFR | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277228 |
| FLT1 | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277230 |
| PDGFRB | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277233 |
| FLT1 | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277229 |