Summary

Name GNAI1
Full Name Guanine nucleotide-binding protein G
Synonyms Adenylate cyclase-inhibiting G alpha protein
Primary ID P63096
Links - -
Type protein
Relations 172
Pathways GPCR_CRC, GPCR_HCC, Neutrophils: G-protein-coupled receptor, Neurotransmitters release, Oxytocin signaling
Inhibitors GDP
Function Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation GNAI1 0.461
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GNAI1 0.2
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GNAI1 0.258
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding GNAI1 0.491
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png Cell_invasion 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.472
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.278
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.508
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TNFAIP8 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.447
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.278
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.578
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.445
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.473
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.289
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.472
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.382
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.469
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding GNAI1 0.489
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.382
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.278
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.514
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.465
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.461
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png 3',5'-cyclic AMP 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release, Oxytocin signaling
+ up-regulates activity img/direct-activation.png binding GNAI1 0.259
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding Adenylate_cyclase 0.632
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.623
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.449
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.285
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.478
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.455
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition GNAI1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.434
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.273
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation GNAI1 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation GNAI1 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation GNAI1 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.277
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.489
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.553
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.447
Publications: 2 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates activity img/direct-activation.png binding GNAI1 0.432
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.252
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.539
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.382
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CDC42 0.521
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding GNAI1 0.302
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.399
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding Tubulin 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding GNAI1 0.405
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.432
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ADCY1 0.55
Publications: 2 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ up-regulates activity img/direct-activation.png binding GNAI1 0.269
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.397
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ADCY6 0.539
Publications: 1 Organism: Spodoptera Frugiperda
+ up-regulates activity img/direct-activation.png binding GNAI1 0.269
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.469
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.434
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.514
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates activity img/direct-activation.png binding HCK 0.345
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding GNAI1 0.461
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.455
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.382
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ up-regulates img/direct-activation.png chemical activation GNAI1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.458
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.494
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.432
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.249
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.432
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.447
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.428
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.416
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.48
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates activity img/direct-activation.png binding GNAI1 0.432
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.293
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.382
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.541
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.546
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.58
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.432
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.456
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.492
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.271
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.308
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.502
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.372
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.313
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.451
Publications: 1
+ up-regulates activity img/direct-activation.png binding GNAI1 0.502
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.449
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.56
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.553
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.412
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.275
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png Cell_migration 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Microtubule_polimerization 0.7
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png Metastasis 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.399
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.464
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.491
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.268
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.284
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SRC 0.483
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding GNAI1 0.401
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.474
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.601
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.554
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.623
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.522
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.434
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.408
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.281
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.294
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png GNAI1 0.502
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PLD2 0.307
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.447
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.265
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.268
Publications: 1 Organism: Cricetulus Longicaudatus
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAC1 0.467
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding GNAI1 0.447
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.25
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ADCY5 0.605
Publications: 1 Organism: Spodoptera Frugiperda
+ up-regulates activity img/direct-activation.png binding GNAI1 0.451
Publications: 1 Organism: Homo Sapiens